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Showing 1 to 16 of 16 for “"Trypanosoma brucei brucei"”.
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Amino acid transporters & amino acid metabolism in Trypanosoma brucei brucei
… transport systems for drug delivery. The Trypanosoma brucei genomic database was screened to identify the full gene repertoire of amino acid transporters. From this, candidate genes were selected and functional genetic approaches were employed to characterise candidate amino acid …
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Effects of Trypanosoma brucei brucei on spatial learning and memory
… results in marked sleep disorder. Studies on the Trypanosoma evansi infection mice model has shown that in addition to the sleep disorder caused by trypanosomiasis disease, learning and memory formation were impaired. Besides, only a little research has been conducted to validate this claim. Thus, …
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Identification and characterisation of an extrachromosomal element from a multidrug-resistant isolate of Trypanosoma brucei brucei
… between a multidrug-resistant isolate of Trypanosoma brucei brucei, CP 547, and a reference drug-sensitive population, ILTat 1.4, led to the identification of a 6.6 kbp extrachromosomal element in the multidrug-resistant population. In light of the involvement of extrachromosomal elements …
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Determination of the role of cytokines using gene deficient mice in African trypanosomiasis infection
… immunological role of IL=12 family members in Trypanosoma brucei brucei, Trypanosoma evansi and Trypanosoma congolense infections, IL-12p35¯/¯, IL-12p40¯/¯ and IL-12p35¯/¯/p40¯/¯ mice were used. While the two latter mouse strains lack all IL-12 homologues, IL-12p35¯/¯ mice still produce …
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Studies of anti-trypanosomal active triterpenoids from some African propolis
… the search for new, affordable and potent anti-trypanosomal drugs with minimal side effects. Bees have the natural way of concentrating higher yields of secondary metabolites in propolis samples when compared to that of the plant source. The aim of this study was to evaluate the fraction VLC6 of …
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Isolation and characterisation of bioactive compounds from Vitex pinnata and associated fungal endophytes
… these compounds exhibited good anticancer, antitrypanosomal and anti-mycobacterial activities. Secondary metabolites isolated from leaves of V. pinnata previously reported to exhibit good anti-inflammatory activity and interestingly the leaves were used by local Malay community to treat cuts and …
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African trypanosomiasis : its effect on platelet morphology, function and survival
… been investigated in experimental infections of Trypanosoma brucei brucei and Trypanosoma congolense in rabbits, and of Trypanosoma vivax in calves. Studies of platelet size, structure, function and survival have been undertaken in an attempt to ellucidate the mechanism for the thrombocytopenia. …
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Synthesis and biological evaluation of 1,4-benzodiazepin-2-one analogues with antitrypanosomal activity
… taken as a privileged skeleton for making antitrypanosomal agents. A library of over sixty 1,4-benzodiazepin-2-one derivatives has been synthesised employing novel synthetic routes. These derivatives were characterised spectroscopically, by mass spectrometry, and by combustion analysis. Five …
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A study of the biological activity of bee venom and its fractions with regard to cosmetic science and immunology
… (Mycobacterium marinum, Norcardia farcinia and Trypanosoma brucei brucei) and human cell lines [NCTC2544 (normal keratinocytes), PNT2A (normal epithelial cells), and HS27 (normal fibroblasts)] respectively. Immunomodulatory effects were investigated in PMA-differentiated U937 cells with and …
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Uncovering the Role of 5'-Nucleotidases in Pyrimidine Metabolism in Trypanosoma brucei
The protozoal parasite Trypanosoma brucei causes the disease African trypanosomiasis in humans and nagana in cattle. Fifty-five million people in subtropical countries are at risk for contracting T. brucei through the tsetse fly vector, and infection is typically fatal if untreated. While recent …
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The Role of Glutathione Synthetase in Trypanothione Biosynthesis in Trypanosoma brucei
Trypanosoma brucei is the causative agent of Human African trypanosomiasis, commonly called sleeping sickness, which is a debilitating disease for which treatment is not currently ideal. Trypanosome parasites differ from their human host by utilizing a novel cofactor termed trypanothione instead of …
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Identification and Characterization of Drug Targets in the Pyrimidine and Purine Pathways of Trypanosoma brucei
The single-celled extracellular parasite Trypanosoma brucei causes Human African Trypanosomiasis (HAT), which is fatal if untreated. Current therapies result in severe side effects and require complex treatment regimens. In an effort to spur the development of effective, safe, and simple to …
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The Function of Phosphatidylinositol 4-Kinase III-Beta in Trypanosoma Brucei
… Two phosphatidylinositol 4-kinases are found in Trypanosoma Brucei. We have cloned the gene encoding the Type III phosphatidylinositol 4-kinase Beta (TbPI4KIII-ß) in Trypanosoma Brucei. The protein was exogenously expressed in COS-7 cells and assayed for phosphatidylinositol kinase activity. The …
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Metabolomic Approaches in Parasitology
… of DHODH inhibitors used to treat human disease. Trypanosoma brucei is a parasitic protozoan and the causative agent of human African trypanosomiasis. The polyamine biosynthesis pathway plays a critical role in cell survival by producing putrescine and spermidine, essential for various cellular …
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Essentiality and Regulation of Deoxyhypusination in Trypanosoma brucei
… trypanosomiasis is caused by protozoan parasite Trypanosoma brucei. T. brucei and other trypanosomatids require spermidine for the formation of trypanothione, a unique thiol-redox factor. In other eukaryotes, spermidine is essential for the (deoxy)hypusination of eukaryotic initiation factor 5A …