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Showing 1 to 20 of 111 for “"Trypanosoma brucei"”.
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Histone Modifications in Trypanosoma Brucei
<p>Trypanosoma brucei maintains an infection in its mammalian host by switching its surface antigen, thus evading host antibodies, in a process known as antigenic variation. Variant surface glycoproteins (VSG), the surface antigen, are expressed from genes located at as many as 20 Expression Sites …
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UTR prediction programs for trypanosoma brucei
In the past few years, the field of bioinformatics has seen a rapid increase in the need for use of various sequence analysis tools. As we advance in the fields of science and technology, new programs and software are constantly being developed in this field. Rapidly expanding gene sequence …
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The PUF proteins in Trypanosoma brucei
The protozoan parasite Trypanosoma brucei, which causes human sleeping sickness, has to adapt to rather different environments as it cycles between the mammalian host and the tsetse fly vector. This adaptation is mediated by changes in trypanosome gene expression, which are mainly regulated at the …
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Studies on fucosylation in Trypanosoma brucei
… recently shown to be essential in the parasite Trypanosoma brucei. Fucose is a common sugar modification on eukaryotic glycan structures, but it has not been well described in trypanosomatids. To elucidate the role of fucose in T. brucei we searched for putative fucosyltransferases in this …
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Regulation of Gene Expression in Trypanosoma brucei
<p>The protozoan parasite Trypanosoma brucei is one of the most divergent well-studied eukaryotes and many discoveries of general interest have been made in T. brucei. Atypical for a eukaryote, in T. brucei genes transcribed by RNA polymerase II (RNA pol II) are arranged in polycistronic …
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Molecular mechanism of Trypanosoma brucei Aquaglyceroporin 2
Trypanosoma brucei subspecies cause Human African Trypanosomiasis, which is fatal unless treated. T. brucei Aquaglyceroporin 2 (TbAQP2) is required for the uptake of two of the drugs used clinically, pentamidine and melarsoprol. TbAQP2 mutations or the formation of a chimeric gene with TbAQP3 …
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Essentiality and Regulation of Deoxyhypusination in Trypanosoma brucei
… trypanosomiasis is caused by protozoan parasite Trypanosoma brucei. T. brucei and other trypanosomatids require spermidine for the formation of trypanothione, a unique thiol-redox factor. In other eukaryotes, spermidine is essential for the (deoxy)hypusination of eukaryotic initiation factor 5A …
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Antigenic Variation and Telomere Structure in Trypanosoma brucei
<p>Trypanosoma brucei survives immune attack in its mammalian hosts by periodically changing the variant surface glycoprotein (VSG). From the ~1000 VSG genes (VSGs) scattered throughout the genome, a few are located at telomere loci called expression sites (ESs) and only one is expressed at any …
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Investigation of conserved Flagellum proteins in Trypanosoma brucei
The single celled protozoan parasite Trypanosoma brucei is an excellent model organism to study eukaryotic cilia and flagella as it has a single flagellum that remains assembled throughout the cell cycle. The new flagellum assembles in a known position relative to the old flagellum, therefore …
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Linkage mapping and genetic analysis of Trypanosoma brucei
Trypanosoma brucei is a protozoan parasite of major public health and economic importance in sub-Saharan Africa, where it is the causative agent of sleeping sickness in man and Nagana in cattle. The complete genome sequence of T.brucei is now available and the diploid genetic system has recently …
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Characterisation of potential Holliday junction resolvases in Trypanosoma brucei
Antigenic variation on the cell surface of the T. brucei is essential for the survival of the parasite in the host immune system. Finding mechanisms to stop variant surface glycoprotein (VSG) switching, and hence the parasites ability to evade the host immune system provides a promising opportunity …
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The characterisation of calpain-like proteins in Trypanosoma brucei
… comprising 25 members in the parasite Trypanosoma brucei. Unique to kinetoplastids, some calpain-like proteins contain N-terminal dual myristoylation/palmitoylation signals, a protein modification involved in protein-membrane associations. We analysed the expression of calpain-like …
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The characterisation of family-13 kinesins in Trypanosoma brucei
… analysis of the 46 kinesin genes coded by the Trypanosoma brucei genome resulted in the grouping of seven kinesin sequences into the Kinesin-13 family. Members of this family have been characterised in a number of model organisms and, unlike most kinesins, do not exhibit microtubule …
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INVESTIGATION OF THE DISTAL APPENDAGE PROTEIN CEP164 IN Trypanosoma brucei
… docking and flagellum length regulation in the Trypanosoma brucei cell is limited and is thought to involve the transitional fibres and surrounding structures. Three diverse Cep164 orthologues in the T. brucei parasite have been identified, but knowledge on their function is limited as …
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Amino acid transporters & amino acid metabolism in Trypanosoma brucei brucei
… transport systems for drug delivery. The Trypanosoma brucei genomic database was screened to identify the full gene repertoire of amino acid transporters. From this, candidate genes were selected and functional genetic approaches were employed to characterise candidate amino acid …
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