Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Trypanocidal activity"”.
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Synthetic studies and biological evaluation of chromone - 3 - carbaldehydes
… is due to their wide range of their biological activity. In this study, three classes of target compounds were synthesized through three different pathways. The first pathway, chromone-3-carbaldehyde analogues were afforded in good to excellent yield followed by the oxidation thereof to …
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Design of potential antiprotozoal daunorubicin derivatives
… rhodesiense in vitro, but which lacks in vivo activity. The object of this work was to modify daunorubicin so as to promote in vivo activity, and to study the mechanism by which daunorubicin is trypanocidal. A series of daunorubicin analogues, and derivatives in which daunorubicin was linked to …
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Amino acid transporters & amino acid metabolism in Trypanosoma brucei brucei
… uptake. Amino acid analogues were tested for trypanocidal activity. Of the 96 tested, two (Azaserine and Levodopa) were investigated in more detail, paying special attention to the nature of their trypanocidal action and possible route of entry through an amino acid transporter. Azaserine …
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Síntese de (±)-licarina a biocatalisada por peroxidase de cocos nucifera.
… hav ing a leshimanicida, schistosomicidal and trypanocidal activity. Its synt hesis occur by the use several methods all of w h ich presente a radical formation which takes places through the action of an oxidizing agent. One of the met hods is the use of enzymes (peroxidases), in this paper …
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New therapeutic strategies against trypanosomiasis and leishmaniasis
… 35 out of 98 tested were observed to exhibit trypanocidal activity better than the original curcumin with EC50 values between 0.05 and 1 µM. Against Leishmania, most of the compounds displayed higher antiparasitic activity than curcumin but lower than observed against trypanosomes. The …