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Showing 1 to 13 of 13 for “"TrxR"”.
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Acetylation regulates Thioredoxin Reductase activity and oligomerization
… cardiovascular disorders. Thioredoxin reductase (TrxR) is the key enzyme in the Trx system and contains the 21st genetically encoded amino acid, selenocysteine (Sec). There were multiple experimentally identified TrxR acetylation sites with an unknown effect on TrxR activity. My thesis tested the …
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자궁내막증 자궁내막에서의 세포증식 증가와 thioredoxin reductase-1 발현의 증가
… 및 세포의 증식도, Bcl-2 단백질과 thioredoxin reductase-1 (TrxR-1)의 발현 정도를 알아보고자 하였다. 연구대상 및 방법 : 복강경과 자궁경을 시행받은 총 631명의 불임 여성 중 자궁내막증을 가진 434명을 실험군으로 자궁내막증이 없는 197명을 대조군으로 하여 자궁내막 용종의 발생율을 조사하였다. 이후 양군에서 얻은 자궁내막조직으로 Ki-67, Bcl-2 단백질과 TrxR-1의 발현을 알아보기 위해 면역조직화학염색법으로 염색한 후 컴퓨터 프로그램 (Imagepro (+), USA)을 이용하여 …
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Biochemical analysis of a potential drug target in the human protozoal pathogen Trichomonas vaginalis
… In this study, recombinant T. vaginalis TrxR and T. vaginalis Trx were produced to test its activity against known TrxR inhibitor, auranofin, using DTNB assay. Cell lysates of metronidazole susceptible and metronidazole resistant lines were also tested to see its activity against …
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Targeting Proteins of Aspergillus fumigatus for Monoclonal Antibody Production
… studies, our lab detected PPIase, Eglc, Ecm33, TrxR and CatB in IA mouse serum and urine, using an antigen discovery platform. In our current work, we seek to develop mAbs that specifically target PPIase, Eglc, Ecm33, TrxR and CatB as an effective diagnostic tool for the invasive fungus …
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DNA-Stabilität und Thioredoxin/Thioredoxin Reduktase im Zellkern
Das System Thioredoxin /Thioredoxin Reduktase(Trx/TrxR) ist ein sehr versatiles System zur neutralisation reaktiver Sauerstoffspezies, zur Regulation redox-sensitiver Vorgänge und zur Aktivierung von Transkriptionsfaktoren wie Steroidhormonrezeptoren, AP-1 und NFkB. Das Enzym Thioredoxin Reduktase …
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Microarray analysis of Trichomonas vaginalis strains T1 and G3: Identifying genes that may contribute to virulence and metronidazole resistance
… One of these genes, Thioredoxin Reductase (TrxR) was then cloned and transfected into T. vaginalis . After confirming expression of the HA-tagged TrxR, the cell line was then used to determine the effect of over-expression of the gene on drug sensitivity. The metronidazole IC 50 for this …
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A Novel Link Between Oxidative Stress Proteins and Estrogen Receptor Alpha-Mediated Gene Expression
… thioredoxin (Trx) and thioredoxin reductase (TrxR). We found that SOD1 interacts with ERalpha, enhances ERalpha-ERE complex formation, influences estrogen responsiveness and associates with estrogen responsive regions of the pS2 and progesterone receptor genes. Furthermore, when MCF-7 breast …
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Characterization of the thioredoxin system in Methanosarcina mazei
Thioredoxin (Trx) and thioredoxin reductase (TrxR) along with an electron donor form a thioredoxin system. Such systems are widely distributed among the organisms belonging to the three domains of life. It is one of the major disulfide reducing systems, which provides electrons to several enzymes, …
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The role of TvTrxR in drug resistance and characterization of TvRad51 in homologous recombination in Trichomonas vaginalis
<p>The Role of TvTrxR in Drug Resistance and Characterization of TvRad51 in Homologous Recombination in Trichomonas vaginalis Abstract By Melissa Hopper University of the Pacific 2016 In recent years, prevalence of metronidazole-resistant cases of Trichomonas vaginalis has been on the rise. With …
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Charakterisierung genomischer Polymorphismen und somatischer Mutationen, sowie der Expression der gastrointestinalen Glutathionperoxidase im Rahmen der kolorektalen Karzinogenese
… benutzt. Die Thioredoxinreduktase-Familie (TrxR-alpha und Trxr-beta) regeneriert oxidiertes Thioresoxin, das in die DNA-Synthese involviert ist und auch in zelluläre Redox-Regulationssysteme eingreift und Transkriptionsfaktoren beeinflusst. Das Selenoprotein P, das bis zu 10 …
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Expression und Regulation von Selenoproteinen in der humanen onkozytären Schilddrüsenkarzinom-Zelllinie XTC.UC1
… der Schilddrüsenhormone involviert ist, die TRxR, die unter anderem die Redoxstatus-abhängige Aktivität verschiedener Transkriptionsfaktoren reguliert, SePP, ein Protein, dem vor allem eine Funktion als Transportprotein zugeschrieben wird, und einige GPx, die während der H2O2-abhängigen …
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Sulforaphan und Selen : Einfluss auf Phase II Enzyme und Selenoproteine sowie deren Effekt auf die entzündungsvermittelte Dickdarmkanzerogenese
… deutlichsten. Die Aktivität des Selenoproteins TrxR wurde hingegen erst bei ausreichender Selenversorgung durch SFN beeinflusst. Die als Nrf2-Zielgen bekannte und in der Hierarchie der Selenoproteine einen hohen Rang einnehmende GPx2 konnte in bestimmten Organen bereits unter selenarmen …
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Charakterisierung von Adenylatkinasen aus Plasmodium falciparum und Thioredoxinreduktase-assoziierten Proteinen aus Dipteren
… (GR) und Thioredoxinreduktase (TrxR) Schlüsselenzyme sind. Ein einzelnes Gen der Taufliege, genannt dmtrxr-1, kodiert sowohl für die durch alternatives Splicing entstehende cytoplasmatische und mitochondriale Form der DmTrxR-1. Zum Teil innerhalb des dmtrxr-1-Gens findet sich auf …