Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 76 for “"Truncations"”.
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Carboxyl terminal truncations of the Phage Mu transposase
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Biology, 1996.
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Genetics and functions of the SARS coronavirus spike protein
… mutations, as well as carboxyl terminal truncations into the protein and investigating these mutants in transient expression experiments. Mutagenesis of either the coiled-coil domain of the S glycoprotein amino terminal heptad repeat, the predicted fusion peptide, or adjacent but distinct …
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Backward stochastic Navier-Stokes equations in two dimensions
… of solutions is shown by the use of suitable truncations and approximations. The continuity of the adapted solutions with respect to the terminal data is also established. The backward stochastic Navier-Stokes equations (BSNSEs, for short) corresponding to incompressible fluid flow in a …
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Complex Proteoform Identification Using Top-Down Mass Spectrometry
… including amino acid substitutions, terminal truncations, and posttranslational modifications. These primary structural alterations play a crucial role in determining protein functions: proteoforms from the same protein with different alterations may exhibit different functional behaviors. …
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Metabolism of Alpha-Synuclein by the 20S Proteasome
… is truncated at the C-termini, and these truncations are hypothesized to participate in disease pathogenesis. The prevailing model for cytotoxicity of the aggregated protein proposes that oligomeric forms cause dysfunction of the ubiquitin-proteasome pathway of protein degradation, thereby …
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Top Down Mass Spectrometry of Archaea and Human Tumor Cells
… methylations, disulfide bonds, and protein truncations. Proteins were also characterized with known coding single nucleotide polymorphisms, alternative splice variants, and highly homologous gene family members.
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Investigation of the Localization, Oligomerization Status, and Binding Activities of Maize Sucrose Synthase
Recombinant SUS1 C-terminal truncations showed that even the first 50 amino acids of SUS1 could bind to microsomes from kernels as well as to cellulose. The secondary structure of the first 50 amino acids of SUS may be causally involved in the binding activities. Taken together, the results …
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Identification of Small Molecule Inhibitors Targeting Truncated Adenomatous Polyposis Coli (APC) as a Novel Therapeutic Strategy in Colorectal Cancer
… Both the gain and loss of function of APC truncations contribute to CRC initiation and progression. Utilizing a series of isogenic immortalized human colonic epithelial cells (HCECs), we have screened a 200K compound library for small molecules that exhibited selective cytotoxicity towards …
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Identification of Small Molecule Inhibitors Targeting Truncated Adenomatous Polyposis Coli (APC) as a Novel Therapeutic Strategy in Colorectal Cancer
… Both the gain and loss of function of APC truncations contribute to CRC initiation and progression. Utilizing a series of isogenic immortalized human colonic epithelial cells (HCECs), we have screened a 200K compound library for small molecules that exhibited selective cytotoxicity towards …
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Modular Temperley-Lieb Theory
… Armed with these new elements, we consider truncations of TLₙ by certain tensors of such generalised idempotents. These algebras are still cellular and can be considered as endomorphism rings of tensor products of indecomposable Uq(𝔰𝔩₂)-modules in the given characteristic. We determine the …
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Investigating the 4-point truncation of the JIMWLK evolution equation
… some order p is necessary. While 2- and 3-point truncations have been studied extensively, this thesis extends the framework to 4-point truncations to capture the physics of 4-point Wilson line correlators. We first refine the parameteri-sation scheme, identifying an additional term required at …
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A Survey of Beta-Sheet Folding: WW Domains With Zinc Fingers and Membrane Peptides
… a WW domain sequence with side-chain mutations, truncations, amide-to-ester exchanges, and loop rearrangements we find that loop structures can dictate the folding dynamics of this model beta-sheet protein. We then report on a synthetic zinc-finger peptide used to bridge the gap between …
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Hyperdefinable groups and modularity
… mod 2) 2. ([1/b,b),*mod b^2 3. (SO_2(M)*) and truncations 4. (E(M)^0,+) and truncations, where E is an elliptic curve over M, where a truncation of a linearly or circularly ordered group (G,*) is a group whose underlying set is an interval [a,b) containing the identity of G, and whose operation …
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Study of the Gain-of-Function Mutant p53 and PARP1 in Triple-Negative Breast Cancer
… CRISPR-Cas9-edited MDA-MB-468 cells with truncations in the C-terminal domain (R273H∆381-388), the C-terminal and oligomerization domain (R273H∆347-393) and a frameshift resulting in very low mutant p53 expression (R273Hfs387). Mutant p53 R273H C-terminal domain truncations decreased …
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Equivariant Modules
… sum of modules of only two kinds: either Mλ or truncations of Mλ . We use our technique to show that each Mλ has a linear resolution and describe also the resolution of its truncations. In Chapter 3 we look at a family of equivariant complexes. One can find this family in the appendix of the …
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Mass spectrometry studies of immunoglobulins
… dissociation (ECD). PTMs observed include truncations, mono-/di-chlorination of the tyrosine residues and a nitrile group formed from the primary amine on lysine side chains. All these may play critical roles in the fibrillogenesis and/or the disease pathogenesis. Experimental evidence …
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Regulation of outer surface lipoprotein A in the Lyme disease spirochete Borrelia burgdorferi
… controlling the expression of OspA. Various truncations of the ospA promoter were created and then studied in our novel in vitro model of ospA repression or grown within the host-adapted model. A T-Rich region of the ospA promoter was determined to be a cis-element essential for both the full …
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An Improvement of Convection Fidelity in Euler Calculations
… diffusion is either built-in through finite truncations or added externally for reasons of numerical stability. The resulting solutions are, therefore, not solutions to the Euler equations but to the pseudo Navier-Stokes equations with numerical viscosity instead of physical viscosity. That …
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Analysis of the subcellular localization of proteins implicated in Alzheimer’s disease
… using the zebrafish animal model. Several truncations of the human PSEN1 and zebrafish Psen1 proteins appear to have differential effects on Notch signalling and Appa cleavage. The basis for these differences is still unclear. Chapter III examines the subcellular localization of fusions of …
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Expression and characterization of recombinant human NEIL3 from Escherichia coli
… tumours. In this project, full length hNEIL3 and truncations of the cDNA have been cloned into the pETDuet-2 expression vector for subsequent expression and purification. Each of the hNEIL3 truncations codes for the N-terminal Fpg/Nei and H2tH domains essential for DNA glycosylase activity, but …
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