Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Trpc4"”.
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Gating Mechanisms of The Canonical Trp Channel Isoform Trpc4
… the mechanism by which the PLC pathway activates TRPC4/C5 remains unclear. Uniquely, TRPC4 is maximally activated only when two separate G protein pathways, G<sub>q/11</sub> and G<sub>i/o</sub>, are co-stimulated, making it a coincidence detector of G<sub>q/11</sub>- and G<sub>i/o </sub>-coupled …
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Mechanism of transcranial focused ultrasound regulating the neuronal activity of the retrosplenial cortex
… potential cation channel subfamily C member 4 (Trpc4) was selected according to the transcriptome sequencing data. Combined with calcium imaging, patch-clamp recording, and short hairpin ribonucleic acid (shRNA) interference, it was found that tFUS could activate Trpc4, which could be blocked by …
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Possible Interacting Proteins for Retinol Binding Protein and Cellular Retinol Binding Protein
… RAIG2 and RAIG3. One hit for CRBP was the TRPC4 ion channel. Retinoic acid inducible gene (RAIG) is a recently discovered family C GPCR and the TRPC4 channel is a membrane ion channel responsible for calcium and sodium ion influxes into the cell. An RBP-RAIG interaction could implicate the …
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Receptor-mediated calcium entry in retinal amacrine cells
… of two TRPC channel subunits, TRPC1 and TRPC4. TRPC1 expression was observed in amacrine cells and their process in the chicken retina. TRPC4 expression was much more widespread with some degree of labeling found in all layers of the retina, and was shown to be expressed in Müller glial …
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Pharmacological regulation and function of store-operated calcium channels
… residues in the extracellular pore region of TRPC4 were involved in the channel opening by Cu²⁺. Moreover, Cu²⁺ showed inhibitory effect on TRPM2 channel.TRPC1/3/4/6 and multiple alternatively spliced variants were detected in the human ovarian adenocarcinoma-derived SKOV3 cells. Blockade of …
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Neurotoxic effects of malathion and lead acetate on the blood-brain barrier: Disruptive effects caused by different mechanisms examined with an in vitro blood-brain barrier system
… by increases in gene expression of TRPC1 and TRPC4 that are associated with increases in the number of TRPC channels on the membrane of endothelial cells of the cerebral microvasculature.