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Showing 1 to 20 of 42 for “"Troponin I"”.
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Contribution of troponin-I to the regulation of cardiac muscle
Troponin-I (TnI) is one of the three components that makes up the troponin complex, which along with tropomyosin regulates striated muscle contraction. The cardiac isoform of TnI (cTnI) has a ~30 residue N-terminal extension, which contains two serines (Ser22/23) that become phosphorylated by …
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Troponin-I-Freisetzung bei kardiochirurgischen Bypassoperationen mit und ohne Herz-Lungen-Maschine
In dieser Studie wurden der Troponin-I-Verlauf, sowie die Serumwerte von Myoglobin, CK und CK-MB prä- und postoperativ nach einem Bypasseingriff am Herzen untersucht. Die Patienten wurden entweder mit Hilfe der Herz-Lungen-Maschine oder im sogenannten Off-Pump-Verfahren operiert. Bei den Patienten …
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A descriptive study of the use of troponin I testing at a Cape Town district hospital
Introduction: Troponin I tests have been shown to be accurate and are relied upon to assist in making critical decisions regarding patient care in patients presenting with chest pain. The tests are expensive, however, and so their rational use becomes extremely important in a budget-constrained …
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Evaluierung der Troponin-I-Freisetzung in der kardialen Lymphe bei herzchirurgischen Eingriffen unter Einsatz des extrakorporalen Kreislaufes
Extracorporeal circulation (ECC) induces a systemic inflammatory response and a perioperative myocardial damage (PMD) leading to postoperative myocardial dysfunction. The cardiac lymphatic system is because of its origin in the interstitial space of the heart, more sensitive than arterial and …
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Der Stellenwert der Troponin-I-(cTnl)- und Troponin-T-(cTnT)-Bestimmung in der Risikostratifizierung von Patienten mit akuter Lungenembolie
… bleibt eine Herausforderung. <br>Kardiales Troponin I (cTnI) und T (cTnT) sind zuverlässige Indikatoren für eine Schädigung des Myokards und können mit einer rechtsventrikulären Dysfunktion bei einer Lungenembolie assoziiert sein. <br>Methoden und Ergebnisse - Die vorliegende prospektive …
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Development of Magnetic Nanoparticle-based Enrichment Techniques and Mass Spectrometry Methods for Quantification of the Clinical Biomarker Cardiac Troponin I
Human cardiac troponin I (cTnI) in serum is a well-known clinical biomarker for cardiac tissue damage and is used for diagnosing myocardial infarction. Unfortunately, commercial cTnI immunoassays from different manufacturers can produce significantly different measurement results for the same …
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Cardiac biomarkers (NT-proBNP and cardiac troponin-I) and point-of-care ultrasound in dogs with cardiac and non-cardiac causes of non-hemorrhagic ascites
… brain natriuretic peptide (NT-proBNP), cardiac troponin-I (cTnI) and point-of-care ultrasound (POCUS) may differentiate between cNHA and ncNHA. Hypothesis/Objectives: This study compared NT-proBNP and cTnI concentrations, as well as POCUS findings in dogs presenting with cNHA and ncNHA. Animals: …
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Structure of Cocrystals of Tropomyosin and Troponin
… Contraction is initiated when calcium binds to troponin, causing it and tropomyosin to undergo conformational changes. Tropomyosin is an $\alpha$-helical protein with two chains (284 residues each) arranged as a coiled-coil. These rod-like molecules form cables wound in the grooves of the actin …
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Exploiting novel antibodies for the early detection of cardiac disease
… importance in healthcare provision. The cardiac troponins are definitive indicators of cardiovascular disease and elevated levels of cardiac troponin I (cTnI) are highly-specific for cardiovascular damage. Using a specific targeting strategy, a panel of novel antibodies were successfully …
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Studies on the Mechanism of Action of Calmodulin
… nucleotide phosphodiesterase (PDE) and with troponin I. Because CaM has been found to behave in a similar manner in most, if not all, of the systems in which it is a participant, information gathered with these systems may be of general relevance. The principal conclusions drawn from this …
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Effects of low and high intensity exercises on serum mean values of myoglobin and heart-type fatty acid-binding protein in athletes
… be done by the combined use of [alpha]-actin and troponin I (TnI). Troponin I (TnI) is only expressed in striated muscle fibers. Slow and fast skeletal TnI (ssTnI and fsTnI) are produced in slow- and fast-twitch (ST and FT) fibers, respectively. Fatty acid-binding protein (FABP) is one of the …
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k-Opioid Receptor Dependent Cardioprotection in the Rat
… resulted in an increased phosphorylation of troponin I and C-protein in isolated ventricular myocytes. Chelerythrine chloride attenuated the U50-dependent increases in troponin I and C-protein phosphorylation.</p> <p> These results indicate that k-opioid receptor dependent cardioprotection is …
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Investigating the link between post-tuberculosis lung disease (PTLD) and circulatory biomarkers in a South African cohort
… angiopoietin-1, TBARS, NT-pro-BNP, and cardiac troponin-I, in patients stratified by the number of previous TB episodes and the time since the last treatment. VEGF and angiopoietin-1 were significantly elevated (up to 6500-fold above normal), with positive correlations to TB episode count. ADMA …
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Development of a fluorescence resonance energy transfer optical nanoscale biosensor based on a liquid-core waveguide platform
… and Respiratory Syndrome virus and human cardiac Troponin I, showing ample sensitivity and a high degree of specificity, as well as rapid response.
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Cardiac Biomarkers in Hyperthyroid Cats
… system. The cardiac biomarkers NT-proBNP and troponin I (cTNI) have proven useful in identifying cats with myocardial disease but have not been as extensively investigated in hyperthyroidism. Hypothesis: Plasma NT-proBNP and cTNI concentrations are higher in cats with primary cardiac disease …
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Effect of a Protein-Carbohydrate Beverage on Muscle Damage During an Acute Bout of Concurrent Exercise in Competitively-Training “Crossfit” Men
… (CK), myoglobin and fast-twitch skeletal muscle troponin-I (sTnI). Eight competitive “Crossfit” men (age, 27.4 + 1.9 yrs; height, 180.4 + 2.4 cm; weight, 92.7 + 3.9 kg; body fat, 15.8 + 1.9 %; BMI 28.4 + 1.1) participated in a randomized, placebo-controlled, crossover study. Subjects performed …
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Protein Biomarkers of Ionizing Radiation and Standardization by MALDI MS/MS and Quantification
… only in the samples exposed to radiation were troponin I, skeletal, fast 2 (up-regulated), aconitate hydratase, mitochondrial precursor (down-regulated), alpha-actinin-2 (down-regulated), pyruvate kinase isozymes M1/M2 (down-regulated) and ATP synthase subunit beta, mitochondrial precursor …
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Prevalence of Occlusive Myocardial Infarction (OMI) in patients diagnosed with Non-ST-Elevation Myocardial Infarction (NSTEMI) at a single private facility in Cape Town, South Africa, during 2019
… 2019, analysing descriptive data, serial cardiac troponin I (cTnI) results, the proportion undergoing angiography, Thrombolysis in Myocardial Infarction (TIMI) flow grades, and door-to-angiogram times. Methods: A cross-sectional, observational study was conducted using a retrospective chart review …
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