Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 107 for “"Tropism"”.
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Cell tropism of maedi-visna virus
… sequence in the LTR of MVV extends the cell tropism of the virus from being strictly macrophage tropic to being able to grow in a variety of cell types, and that this extended cell tropism is associated with neurovirulence. LTR is the virus promoter region and contains enhancer sequences that …
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Factors That Influence Murine Norovirus Stability and Tropism
… that influence murine norovirus stability and tropism through two independent projects. Murine norovirus (MNV) is a model system used to study human noroviruses due to its robust replication in cell culture and mouse model. I first investigated the interactions between MNV and bacteria in vitro …
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Virus tropism and neutralization response in SIV infection
… as alternatives. We have studied virus tropism and evolution of the humoral immune response in relation to pathogenesis in cynomolgus macaques experimentally infected with SIVsm (of sooty mangabey origin) by intravenous (IV) or intrarectal (IR) route. Route of transmission did not …
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Defining the tropism of Listeria monocytogenes using a comparative genomics approach
… identifying genomic features responsible for the tropism of the microorganism for clinical, food and environmental niches. Comparative genomic techniques, namely mixed-genome microarrays, dot-blot hybridization and suppressive subtractive hybridization were used to compare the genomes of L. …
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PATTERNS OF NATURAL SELECTION ASSOCIATED WITH TROPISM SHIFTS IN ANIMAL CORONAVIRUS GENOMES
Viruses may acquire mutations that result in a tropism shift. RNA viruses, such as Coronaviruses (CoVs), are susceptible to tropism shifts. A tropism shift occurs when a virus alters the tissue or cell type it infects, which can have important implications for disease pathogenesis, virulence, …
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Investigation of the cellular tropism and in vivo distribution of HIV-1
… area which continues to attract attention is HIV tropism. HIV requires two receptors- CD4 and a co-receptor- for infection. In vivo, HIV variants mainly use either CCR5 or CXCR4 as co-receptors and thus variants can be classified as either R5 (CCR5 using), X4 (CXCR4 using) or (R5X4) (dual tropic). …
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Epidemiology, molecular characterisation and tropism of the Hepatitis G Virus / GBV-C
The hepatitis G virus and GBV-C are recently discovered variants of the same virus belonging to the family Flavivirus (HGV/GBV-C). Although initially thought to be a hepatitis virus, it has been shown to have no association with liver disease. No work has been performed on the prevalence or …
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Investigating the effects of pH on alphaviral E3-E2 glycoprotein association, organization, and cellular tropism
<p>In alphaviruses the role of E3 is required in protecting the fusion peptide region of E1 during intracellular transport. Throughout viral processing, the association of E2 and E3 is required for the successful trafficking and incorporation of E1 into the mature virion. This E3-E2 association has …
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Avian Infectious Bronchitis Virus: A Tropism for the Rooster Reproductive Tract and Effects on Reproductive Performance
The epididymal region of the rooster consists of the rete testes, the efferent ductules and the epididymal duct. In the epididymal region, the spermatozoa gain the ability to move and acquire surface proteins. The specialized microenvironment of the epididymal region is vital for these developments …
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Molecular basis oh herpes simplex virus entry into the cell and retargeting of the viral tropism for the design of oncolytic herpesviruses
… distinct projects: I. The retargeting of viral tropism for the design of oncolytic Herpesviruses: • capable of infecting cells through the human epitelial growth factor receptor 2 (HER2), overexpressed in highly malignant mammary and ovarian tumors and correlates with a poor prognosis; • …
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HIV-1 evolution, disease progression and molecular epidemiology of HIV-1 single and HIV-1 and HIV-2 dual-infected individuals in Guinea-Bissau
… HIV-1 evolution, disease progression, coreceptor tropism and molecular epidemiology of HIV-1. All sequences were derived from single (HIV-1 only) or dual-infected (HIV-1 and HIV-2) individuals from Guinea-Bissau, West Africa. The main findings was that CRF02_AG represents the most common form of …
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뇌종양 동물모델에서의 인간신경줄기세포주의 종양으로의 특이적 이주에 관한 입체적 분석
… assays 4 4. In vivo analysis of tumor-tropism of human neural stem cells 5 5. X-gal stain 6 6. Cell count and unbiased stereology in a tumor region of rats 7 7 .Cell count and unbiased stereology in a entire brain of rats 8 8. Labeling of F3 Cells with 5-bromo-2-deoxyuridine 8 9. …
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Molecular Basis of Adaptation of Enteroviruses to Different Cancer Cell Lines
… of CVA9 and echovirus cell/receptor tropism. Several echoviruses and CVA9 variants were tested in a panel of 9 cell lines. Distinct patterns of infection were seen, but did not fully correlate with receptor expression, suggesting that other determinants also help to define tropism. To …
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Generation and Characterization of Flavivirus Receptor-Binding Domain Mutants and Chimeras
… the role of EIII in virus growth and tissue tropism, chimeric viruses were generated using the West Nile virus (WNV) infectious clone, into which EIIIs from a range of flaviviruses of increasing genetic diversity from WNV were substituted. Four versions of each chimera were generated using …
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Factors affecting replication and cross-species transmission of feline immunodeficiency virus
… of accessory protein Vif. Viral entry and tissue tropism are determined by an interaction of the viral Env glycoprotein with a cell surface receptor and a seven transmembrane domain co-receptor. The feline immunodeficiency virus (FIV) infects diverse felid species including the African lion, where …
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Reconstructing Cross-Species Ancestral Adeno-Associated Viruses for Enhanced Gene Therapy Delivery
… (BBB). Additionally, their broad and nonspecific tropism can translate into suboptimal cross-species transduction efficiency and potential toxicity, complicating the clinical transition from animal model to humans. These challenges impede the use of naturally occurring AAVs for therapeutic gene …
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Investigation of the interplay of yellow fever virus structural protein epitopes and genetic diversity
… through its role in genetic diversity, tissue tropism and recognition by WT and vaccine specific antibodies that bind E protein. Using infectious clones (i.c.) of both Asibi and 17D viruses, structural chimeras with swapped prME, E protein domain III (EDIII) and single site mutations at each of …
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Investigating intrathecal adeno-associated virus vectors for the study of analgesic interactions at the spinal level
… 9. The results obtained demonstrate differential tropism of AAV vectors for subpopulations of primary afferent neurons and some brain areas. The second part of this thesis characterizes interactions between spinally delivered combinations of an opioid and an adrenergic agonist, or two opioid …
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