Global ETD Search
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Showing 1 to 13 of 13 for “"Trophoblast stem cells"”.
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Cell lineage choice during differentiation of trophoblast stem cells (tsc) is dependent on oxygen levels, and mediated by stress enzyme pathways and mitochondrial function
… organ/tissue or cellular response. Trophoblast tem cell (TSC) is one of the earliest differentiated stem cell within blastocyst, which is the stage of preimplantation embryo developed from fertilized egg. Different from another pluripotent embryonic stem cell, which is derived from …
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Role of Endoplasmic Reticulum Stress in Trophoblast Stem Cell Differentiation
… reticulum (ER) stress on the differentiation of trophoblast stem cells (TSCs), placental development, and subsequent pregnancy outcome. To address this question, I first used an in vitro mouse TSC model. Morphological observations suggest that upon ER stress, TSCs lose stemness by differentiating …
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Lack of Inflammatory Response in Mouse Embryonic Cells to Listeria Infection
… within mouse blastocysts, including embryonic stem cells (ESCs) and trophoblast stem cells (TSCs), exhibit remarkable resilience against the cytotoxic effects associated with viral infections and embryotoxic cytokines, such as TNFα and IFNγ, both of which are known to hinder blastocyst …
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Multilineage modelling of early placental responses to pathogens at single-cell resolution
… vitro and ex vivo placental models such as human trophoblast stem cells (hTSCs), organoids, and placental explants, and perform a comprehensive single-cell transcriptomic analysis of their responses. Firstly, I outline the physiological structure and role of the placenta in supporting and …
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Syncytiotrophoblast formation is influenced by genes involved in lipid biology
… exchange occurs in the labyrinth, the syncytiotrophoblast (SynT) cells are the key cell type of this region. Multinucleated SynT cells are formed through the process of trophoblast fusion involving a lipid- signalling event and dynamic membrane rearrangement. Defects altering the structure and …
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A multi-lineage in vitro mouse embryo model derived exclusively from mouse embryonic stem cells
… placenta and yolk sac respectively. By using stem cells derived from these three fundamental lineages, many *in vitro* models have been developed to recapitulate various events of post-implantation development. Using only mouse embryonic stem cells (ESCs), the gastruloid model has been …
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Genome-wide search for regulators of the first cell lineage decision in the mouse: a CRISPR/Cas9 endeavour
… of their embryonic counterparts: embryonic stem cells (ESCs) are pluripotent and similarly to ICM contribute to all tissues in the embryo proper, being generally excluded from the extraembryonic layer. On the other hand, trophoblast stem cells (TSCs) resemble TE and are restricted to the …
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Role of Histone Lysine Demethylase, KDM1B, in Trophoblast Stem Cell Self-Renewal and Differentiation
… types. Reflecting this developmental plasticity, trophoblast stem cells (TSCs) can be derived from the TE of mouse blastocysts. TSCs have proven an invaluable research tool to study processes of early placentation in vitro. Despite the placenta’s central role in reproduction, our understanding of …
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Trophoblast specification and differentiation potential in early human and non-human primate embryogenesis
Implantation is mediated by trophoblast, the outer layer of the early embryo. Trophoblast is an extraembryonic tissue that gives rise to the placenta, which sustains fetal growth and development. Human embryo implantation and early trophoblast development have remained elusive due to the …
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Utilising embryonic and extra-embryonic stem cells to model early mammalian embryogenesis in vitro
… can be captured in vitro as mammalian embryonic stem cells (ESCs). Although mouse ESCs have been shown to contribute to all adult tissues in chimeric embryos, they cannot undertake embryogenesis when allowed to differentiate in culture. Previous studies have shown that ESCs formed into …
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Hyperosmotic Stress Enzyme Signaling Modulates Oct4, Nanog, And Rex1 Expression And Induces Prioritized Differentiation Of Murine Embryonic Stem Cells
… DIFFERENTIATION OF</p> <p>MURINE EMBRYONIC STEM CELLS</p> <p>by</p> <p>JILL SLATER</p> <p>MAY 2013</p> <p>Advisor: Daniel Rappolee, Ph.D.</p> <p>Major: Physiology</p> <p>Degree: Doctor of Philosophy</p> <p>Transcription factor expression and therefore lineage identity in the …
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Acetyl-CoA metabolism and human trophoblast differentiation
Cytotrophoblasts are trophoblast stem cells that undergo rapid self-renewal and differentiation during early pregnancy. Disruptions in this process can lead to impaired placentation or placental dysfunction leading to complications in pregnancy. This thesis investigates the role of ATP citrate …
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The expression and regulation of pregnancy-specific glycoproteins in the mouse
… and are predominantly expressed in the syncytiotrophoblast of human placenta and in giant cells and spongiotrophoblast of rodent placenta. PSGs are encoded by seventeen genes in the mouse and ten genes in the human. Little is known about the function of this gene family, although they have been …