Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"TrmD"”.
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Inhibition of enzymes from mycobacteria using fragment-based approaches
… (Mtb) and tRNA (m1G37) methyltransferase (TrmD) from Mycobacterium abscessus (Mab). With Mtb fumarase a high-throughput screening (HTS) hit was used to design a small library of fragments in a deconstruction-reconstruction approach. These fragments were screened using a range of both …
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Magnesium regulates transcription of the mgtA (magnesium transporter) gene in Salmonella enterica serovar typhimurium via prolyl-bond formation during translation of the mgtL leader ORF
… EF-P and methylation of tRNAPro with m1G37 by TrmD both play roles in the regulation of <em>mgtL</em>translation. Of potential significance is that TrmD is dependent on Mg2+ for its tRNA methylation activity, implying an underlying role of Mg 2+ in the regulation. We suggest a complex …
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Targeting Mycobacterium abscessus Infection in Cystic Fibrosis: A Structure-guided Fragment-based Drug Discovery Approach
… intervention. While fragment hits of target 1, TrmD (tRNA-(N1G37) methyl transferase), were prioritized, whereby two chemical series were developed using fragment growing and merging approaches. Iterative fragment elaboration cycle, aided by crystallography, biophysical and biochemical assays …