Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"TrkB.T1"”.
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Mechanism and Function of TrkB.T1 Astrocyte Expression
… the truncated tropomyosin receptor kinase B (TrkB) receptor. TrkB is the primary receptor for BDNF which is broadly expressed and released by neurons in developing and mature brain. TrkB has two predominant isoforms expressed in central nervous system (CNS), the full length TrkB (TrkB.FL) …
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Truncated Tyrosine Kinase Receptor B (TrkB.T1) plays a role in susceptibility to chronic stress
… factor (BDNF) and tyrosine kinase B (TrkB) have been implicated in depressive/anxiety disorders. The efficacy of antidepressants may be related to BDNF-TrkB signaling fueling neuroplastic changes. TrkB.T1 might have novel signaling effects that may be relevant for dealing with …
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BDNF and Astrocyte TrkB.T1 Signaling as a Mechanism Underlying Astrocyte Synapse Interactions in Motor and Barrel Cortex
… investigates the role of the astrocyte TrkB.T1 receptor, a truncated isoform of the canonical receptor for brain derived neurotrophic factor (BDNF), in mediating behavior and excitatory synapse development. Using an astrocyte-specific conditional TrkB.T1 knockout mouse model, we …
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Identification and validation of new therapeutic targets for squamous cell lung cancer
… genes in SOX2-high tumours, and identified TrkB (encoded by the *NTRK2* gene) as a potential drug target candidate. Expression of TrkB correlated with SOX2 expression in squamous tumours, showed a functional role in squamous cancers, and *NTRK2* was confirmed as a transcriptional target of …