Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"TrkA"”.
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Analisi funzionale dei recettori per le neurotrofine p75NTR e Trka in neuroblastoma
… by binding two distinct Neurotrophin receptors, TrkA and p75NTR. While several reports have provided lines of evidence on the interaction between TrkA and p75NTR at the plasma membrane, much fewer data are available on the consequence of such an interaction in terms of intracellular signaling. In …
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Expression und Funktion von Caveolin bei glialen Zellen, insbesondere Oligodendrozyten
… hochaffinen NGF (nerve-growth-factor) Rezeptors TrkA innerhalb von CMD sowie eine direkte Interaktion von Caveolin und TrkA nachgewiesen werden. Die Rolle von CMD bei der NGF regulierten Signaltransduktion, die die Myelinbildung im ZNS steuert, scheint von der Caveolinkonzentration abzuhängen, …
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Perineural Invasion in Oral Squamous Cell Carcinoma and Salivary Gland Malignancies: Incidence, Prognostic Impact and Molecular Insight
… (NGF) and its high affinity tyrosine kinase A (TrkA) receptor have been identified as being possibly of importance in PNI. The PI3K/Akt signalling pathway is a well-established driver of cancer progression, however, the mechanism of NGF-induced Akt phosphorylation remains unclear. Identifying …
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The impact of reduced neuronal p75NTR expression on sensory neuron phenotype and associated glia
… and NaV1.9, the nerve growth factor receptor TrkA, the potassium channel Kir4.1, glial fibrillary acidic protein (GFAP), SGC p75NTR, connexin 43, we intrathecally infused p75NTR anti-sense oligonucleotides (AS OGN), previously shown by Obata et al. (2006) to effectively suppress p75NTR …
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Evaluation of inhibitors of histone deacetylases as potential neurotrophic agents
… of MEK1/2 (PD98059/U0126) PI3K (LY294002) and TrkA (GW441756) and phosphorylation of target kinases. Associated factors namely, acetylation of histones (H3/H4) and α-tubulin, role of cAMP, and cell- cycle analysis with flowcytometry were also studied. </p> <p>Vorinostat, a pan HDAC inhibitor, …
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Neurotrophins and neurotrophin receptors in adult primary sensory neurons
… of neurotrophins on individual neurons. Like trkA, neuronal expression of trkB and trkC mRNA is reduced following axotomy, suggesting a neurotrophin-deficient state and a role for these molecules in promoting normal phenotype. Secondly, neuronal BDNF was characterized in intact, axotomized and …
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Nerve growth factor regulates Na+ transport in human airway epithelial cells
… or the Na+/K+-ATPase. To investigate if the trkA receptor was responsible for mediating the NGF-induced reduction in Na+ transport, the non-specific tyrosine kinase inhibitor, K-252a (10 nM, apical), was used. K-252a reduced the NGF bioelectric response as well as attenuated the NGF-induced …
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Interactions of Thyroid Hormones, Nerve Growth Factor and Its Receptors in Development and Plasticity of the Rat Olfactory Bulb
… NGF receptors, p75$\sp{\rm NTR}$ and trkA in the glomerular region. We propose that decreased bulbar NGF results in decreased trophic support for specific NGF responsive cells, leading to compensatory up-regulation of NGF receptors which compete for the limited supply of NGF. Thyroid …
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TrkB and gene expression
… Neurotrophins bind the Trks receptor family (TrkA, B, C). NGF is the preferred ligand for TrkA, BDNF and NT4/5 are preferred for TrkB, and NT3 for TrkC, although NT3 also binds with less affinity to TrkA and TrkB. During my PhD I have focused my interest in understanding how neurotrophins …
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Delineating The Mechanism(S) of Bdnf/Trkb Mediated Proliferation In Neuroblastoma
… precursor cells. The neurotrophin receptors (TrkA/B/C) have been implicated as important prognostic markers, linking the biology of the tumor to patient outcome. High expression of TrkA and TrkC receptors have been linked to favorable biological features and high patient survival, while TrkB …
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The exploitation of neuronal survival factors in Burkitt’s lymphoma and germinal centre B cells
… high affinity Tropomyosin receptor kinases TrkA, TrkB and TrkC and the (common) low affinity, tumour necrosis factor receptor member, p75NTR. FDC-like cell lines were also analysed for neurotrophin component expression. This was to question FDCs as potential providers of paracrine …
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Investigation into the molecular mechanisms of congenital insensitivity to pain
… of the functions and the role of key residues of TRKA within the cell. I have verified the importance of NGF in the development of nociceptors and demonstrate the overlapping roles of the precursor proNGF with mature NGF as well as providing insight into the role of proNGF as a neurotrophic …
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Μελέτης [sic] της αγγειογενετικής δράσης του νευρικού αυξητικού παράγοντα (NGF) σε μοντέλο ισχαιμίας οπίσθιων άκρων κονίκλων
… Ο συνδυασμός του NGF είτε με αναστολέα του TrkA είτε με αναστολέα του VEGFR-2, κατήργησε την αιμοδυναμική ανάρρωση που προκάλεσε ο NGF. Αυτό δείχνει εξάρτηση της αγγειογενετικής δράσης του NGF τόσο από το δικό του υποδοχέα άμεσα, όσο και από τον υποδοχέα του VEGF έμμεσα. Τα ανωτέρω ευρήματα …
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Effects of nerve growth factor on TGF-Beta,Smad signal transduction in PC12 cells
… of TGF-ß. Binding of NGF to functional TrkA receptors triggers activation of Smad3. This NGF-dependent Smad activation occurs by a mechanism which is different from being induced by TGF-ß receptors in that it provokes a different phosphorylation pattern of R-Smads. Together with an …
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Using Xenopus laevis to study the mechanisms governing the early germline development and the formation of vertebrate body plan
… three neurotrophic tropomyosin receptor kinases, TrkA, TrkB, and TrkC. We envision that these ligand-independent optogenetic RTKs will provide useful toolsets that allow for the delineation of signaling subcircuits in developing vertebrate embryos.
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Μορφολογική μελέτη της έκφρασης των υποδοχέων κινάσης τυροσίνης Trks (υποδοχείς νευροτροφινών) και VEGFR-3 και συσχέτισή τους με την οδό μεταγωγής σήματος EpoR/ JAK-2/ STAT-5 στους όγκους εγκεφάλου του ανθρώπου
… ανοσοδραστικότητα για τους υποδοχείς TrkA (57%), TrkB (56%) και TrkC (46%). Όλα τα ολιγοδενδρογλοιώματα και τα επενδυμώματα που εξετάσθηκαν ήταν αρνητικά για τους υποδοχείς Trk ενώ έκφραση των υποδοχέων ανιχνεύθηκε σε μικρό ποσοστό των μυελοβλαστωμάτων. Στις ανοσοθετικές περιοχές των …
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Isoform-Specific Roles of Extracellular Signal-Regulated Kinases in Pain
… afferents that express the NGF receptor, TrkA. The partial reduction in epidermal innervation is not accompanied by cell loss, suggesting a defect in axon growth or maintenance. Fiber loss is unlikely to account for all behavioral phenotypes observed in ERK2f/f;NaV1.8-Cre mice since …
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Rôles et mécanismes d'action du récepteur AT[indice inférieur 2] de l'angiotensine II d'un modèle cellulaire neuronal au tissu prostatique humain l'importance du contexte
… que le récepteur AT 2 induise l'activation de TrkA, Rapl et p42/p44mapk . De plus, l'expression de la protéine Fyn native (Fyn-WT) augmente à elle seule l'élongation neuritique, alors que l'expression de sa forme dominant-négative (Fyn-DN) inhibe cet effet induit par l'Ang II. Cependant, aucun …
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