Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Trithorax"”.
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In silico analysis of Polycomb/Trithorax response elements in Drosophila and mammals based on DynScan : an alignment independent sensitivity increasing framework for cross-species prediction of regulatory elements
… die Genexpressionsmuster bestimmen, und Polycomb/Trithorax Response Elements (PREs). Diese übernehmen die Funktion der Enhancer und erhalten die Genexpressionsmuster hunderter Gene aufrecht, die besonders wichtig für die Zellentwicklung sind. PREs sind essentiell für die korrekten Identitäten von …
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Modelling chromatin dynamics in neural stem cell quiescence and reactivation
… induction. Moreover, quiescent cells gain more Trithorax chromatin domains and revert to a less accessible state upon reactivation. I also showed that genes necessary for neurotransmitter-based signalling become upregulated in quiescence by transitioning form H1-bound repressive heterochromatin …
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The role of MLL4 in the chromatin framework: from the epigenome to 3D genome organization
MLL4 is a histone methyltransferase of the Trithorax (TrxG) group, crucial for maintaining active gene expression by antagonizing Polycomb (PcG) proteins, which enforce repressive states. Proper TrxG-PcG crosstalk is critical for various cellular processes and for determining cell fate. Although …
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Entwicklung eines DNA Microarrays zur genomweiten Analyse Polycomb-vermittelter Genregulation in Drosophila melanogaster
… spielen, sind die Polycomb-Gruppe und die trithorax-Gruppe. Während die trithorax- Gruppe die Aufgabe erfüllt, das Expressionsmuster von aktiven Genen während der Entwicklung aufrecht zu erhalten, kommt der Polycomb-Gruppe die Aufgabe zu, den reprimierten Zustand von Genen über viele …
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Analysis of an epigenetic regulator in mouse embryonic stem cell self-renewal and differentiation
… Mll and Trx2, for the Drososphila protein Trithorax (TRX), which is the founding member of the trithorax group (TrxG) of epigenetic regulators. TrxG proteins are characterized by an evolutionary conserved SET domain. A major function of all SET domain- containing proteins is to modulate …
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Untersuchungen epigenetischer Eigenschaften des chromosomalen Elements Fab7 und der beteiligten Mechanismen in Drosophila melanogaster
… aufrechterhalten. Die Genprodukte der trithorax-Gruppe (trxG) wirken als positive Regulatoren und erhalten die Expression der Zielgene, während die Produkte der Polycomb-Gruppe (PcG) als negative Regulatoren dienen und reprimierende Funktionen ausüben. Die Produkte beider Genklassen …
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Synovial sarcoma : translating gene expression into patient care
… through aberrant targeting of both activating (trithorax, SWI/SNF) and repressing (Polycomb) transcription factors when expressed in a stem or progenitor-like cellular background. Clinically, synovial sarcomas present considerable diagnostic and therapeutic challenges. Whereas the classical …
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Epigenetic Regulation of Muscle Stem and Progenitor Cells
… and maintenance. Important roles for the trithorax H3K4 histone methyltransferase (HMT) MLL1 have been established for early embryogenesis, and for hematopoietic and neural identity. Here, using a conditional Mll1 knockout (KO), we find that in vivo, MLL1 is necessary for efficient muscle …
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The role of cellular memory modules in the determination and transdetermination of Drosophila melanogaster imaginal disc cells
The Polycomb-group (PcG) and trithorax-group (trxG) proteins ensure this function through their interplay at chromosomal elements, termed Cellular Memory Modules (CMMs), by creating stable and inheritable chromatin structures. By this way, CMMs are able to remember the embryonic state of …
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The function of chromatin regulators during patterning and growth in Drosophila wing disc regeneration
… to the SWI/SNF complexes, which belong to the Trithorax group (TrxG) of chromatin regulators, I investigated the roles of Polycomb, which belongs to the Polycomb Group (PcG) of chromatin regulators, during tissue regeneration, as described in Chapter IV. Reduction of Pc showed enhanced …
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Regulatory Architecture of Non-Apoptotic Cell Death Program in C. Elegans
… 4 methyltransferase complex centered on the Trithorax/MLL-like catalytic subunit SET-16. I then demonstrated that two opposing spatial cues, the Wnt ligands EGL-20 and LIN-44, cooperate with LIN-29 to control linker cell death initiation. I showed that the Abdominal- B-like Hox transcription …
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Identifizierung und Charakterisierung von Histonmethyltransferasen in Drosophila melanogaster
… ein bekannter epigenetischer Aktivator der Trithorax-Gruppe. ASH1 methyliert in Histon H3 Lysin 4 und 9 und in Histon H4 Lysin 20. Die ASH1-abhängige Transkriptionsaktivierung konnte mit der Methylierung der drei Lysin-reste in der Promotorregion von ASH1-Zielgenen korreliert werden. Mittels …
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Role of Non-Coding RNA NC4 in MLL and CYP33 Mediated Regulation of HOXC8
… a transcriptional maintenance protein from the Trithorax Group (TrxG) that resides in complex with other chromatin regulators to maintain the downstream target genes, in particular the HOX genes, in their active state of transcription. A nuclear cyclophilin called CYP33 interacts with the third …
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A role for myotubularins in vaccinia virus egress
… protein (MTMR) 1 and su(var), enhancer of zeste, trithorax (SET)-binding factor (SBF) 1 were identified as major hits for the joint interactome of E2 and F12. This thesis has investigated the potential role of these and other cellular proteins in IEV egress. MTMR1 and SBF1 both co-precipitated …
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Regulation of cellular memory by non-coding transcription through Polycomb group response elements
… PcG (Polycomb group) and activating TrxG (Trithorax group) proteins. The recruitment of both PcG as well as TrxG proteins to their target loci depends on the presence of identical cis-regulatory elements termed Polycomb group response elements, or PREs. How is the decision between …
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Investigating transcription factor dynamics and chromatin environment during Notch response
… salivary glands revealed recruitment of Moira, Trithorax-related (Trr) and Mi-2, representative members of 3 different chromatin complexes, to the Notch target locus E(spl)-C. All three factors were recruited in Notch active conditions and contributed to the efficacy of the transcriptional …