Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"Triterpene"”.
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Combinatorial biochemistry of triterpene saponins in plants
… metabolite profiling confirmed the induction of triterpene saponin biosynthesis by methyl jasmonate treatment, a genome-wide cDNA-AFLP transcript profiling was carried out for the five plants. Taking into account the putative functional annotation and the expression pattern of the visualized …
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Approaches to the synthesis of stelliferin, a marine isomalabaricane triterpene
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1996.
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The Cardioprotective effect of a Lanosteryl Triterpene from Protorhus Longifolia on H9c2 Cardiomyoblasts
Introduction: Diabetes mellitus is a predisposing factor of cardiovascular diseases (CVDs). Globally, CVDs are the prominent cause of death in both diabetic and nondiabetic individuals. In an effort to fight the disease burden, more researchers are looking into natural-products as adjunctive …
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Evaluation of the in vivo anti-hyperlipidemic activity of the triterpene from the stem bark of Protorhus longifolia (Benrh.) Engl.
… agents, preferably of natural origin. Triterpenes are now targets for drug development due to their diverse, potential significant pharmacological activities. In this study, the in vivo lipid-lowering activity of the triterpene (Methyl-3β-hydroxylanosta-9,24-dienoate), isolated from …
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Glycemic control and pancreatic beta cells protective effect of a lanosteryl triterpene from Protorhus longifolia in hyperlipidemic and STZ-induced diabetic rats
… beta cell protective effect of a lanosteryl triterpene (RA-3) from Protorhus longifolia stem bark in hyperlipidemic and streptozotocin-induced diabetic rats. RA-3 was isolated from the chloroform extract of P. longifolia using chromatographic techniques and its chemical structure was …
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Neuroprotective Potential of a Lanosteryl Triterpene from Protorhus longifolia Stem Bark (Benrh.) Engl in high fat diet fed and STZ -induced diabetic neuropathy in rats
… the neuroprotective potential of lanosteryl triterpene (RA-3) from Protorhus longifolia stem bark in high fat diet (HFD) fed and streptozotocin (STZ) -induced diabetic neuropathy in rats. The triterpene was isolated from the chloroform extract of P. longifolia stem bark using silica gel …
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Enhanced yield of medicinal products from Tripterygium cell cultures
… of pharmacologically active diterpene and triterpene natural products. A method was developed where elicitation with a strain of the fungus Botrytis stimulated the production of oleanane and friedelane triterpene acids. In rapidly growing twelve liter bioreactor cultures, triterpene yields …
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I. Sulfonium-Mediated Oxidative Glycosylation of Glycal Donors for the Synthesis of C(2)-Hydroxy-Beta-Glycosides. II. Hypervalent Iodine (iii)-Mediated Oxidative Glycosylation of Glycal Donors for the Synthesis of C(2)-Acyloxy-Beta-Glycosides. III. Efforts Toward the Synthesis of Immunologic Adjuvant Qs-21a(api)
… In the third section of this thesis, an acylated triterpene glycoside QS-21Aapi was targeted for synthesis using the two oxidative glycosylation procedures as well as a sulfonium-mediated dehydrative glycosylation procedure. Synthesis and extraction of the four components of the saponin, which …
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Adaptive metabolic gene clusters as toolkits for chemical innovation: Investigation of the origin of the avenacin gene cluster for synthesis of defense compounds in oats
… analysis of the �ve gene families implicated in triterpene biosynthesis: oxidosqualene cyclases, cytochromes P450 51s, Clade 1A serine carboxypeptidase-like acyltransferases, Class I O-methyl transferases and Group L glycosyltransferases in monocots. Phylogenetics analyses show that these gene …
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Biochemical and Functional Characterization of Induced Terpene Formation in Arabidopsis Roots
… a root-specific oxidative degradation of the C30-triterpene precursor arabidiol thereby causing the release of DMNT and a C19-degradation product named arabidonol. We found that DMNT shows inhibitory effects on P. irregulare mycelium growth and oospore germination in vitro, and that DMNT …
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Isolation and Structure Elucidation of Cytotoxic Natural Products from the Rainforests of Madagascar and Suriname
… known compounds - a naphthoquinone dimer and a triterpene. Both of these structures are new to the Cordia genus of plants and showed moderate bioactivity. An extract of a Monoporus species yielded a known triterpene saponin. The compound has been previously located in the same plant family, but …
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Therapeutic Effect of a triterpenic Acid from Protorhus longifolia Against High Fat Diet Fed and Streptozotocin-induced Diabetic Nephropathy in Rats
… potential of a plant-derived lanosteryl triterpene (RA5), against high fat diet (HFD) fed and streptozotocin (STZ)- induced diabetic nephropathy in rats. RA5 was isolated from the chloroform extract of Protorhus longifolia stem bark. Chemical structure of RA5 was confirmed based spectral …
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Potential functionality and digestibility of oryzanol as determined using in vitro cell culture models
… broken down by cholesterol esterase and produced triterpene alcohols or sterols and ferulic acid, which were further degraded. The degradation of γ-oryzanol in the stomach may undergo a different pathway because sterols or triterpene alcohols were also not found after peptic digestion.
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Synthesis of delta-1(9)-octalinols and their analogues
… by the observation that a natural glyeoside of a triterpene, which incorporated the allylic alcoholic moiety 1 gave the novel ketone diene 2 when it was subjected to acetolysis. A number of octahydronaphthalinols (1, R=H) Δ 1 ( 9) octalinols), ' were prepared by reduction of the α, β unsaturated …
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Stereospecific Syntheses from Podocarpic Acid
The triterpene precursor, 12-methoxypodocarpa-8,11,13-trien-3-one (46)*, has been prepared via the 3a-alcohol (48) formed by opening of the 3a,4a-epoxide (13) with lithium diethylamide. The total synthesis of the methyl ether of the natural product, (+)-hinokione, has been achieved by a similar …
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Synthesis of Saponin Immunoadjuvants
… comprises an isomeric mixture of complex triterpene saponins and is currently the most promising immunopotentiator in several antitumor and infectious disease vaccine therapies. However, the clinical use of QS-21 has been hindered by the difficulty in obtaining sufficient quantities of …
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Studies of anti-trypanosomal active triterpenoids from some African propolis
… VLC6 of the propolis sample and the isolated triterpenes for their anti-trypanosomal activity using an Alamar Blue assay. The chromatographic separation of the fraction VLC6 of propolis sample from Cameroon resulted in the isolation of the fraction 710.58Fr8 with a relatively high yield of …
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Celastrol induces paraptosis-like cell death via mitochondrial Ca2+ overload in breast cancer cells
… understood. Recently, we found that celastrol, a triterpene extracted from the Chinese “Thunder of God Vine”, induced paraptosis accompanied by dilation of mitochondria and the ER in MDA-MB 435S and MCF-7 breast cancer cells. Inhibition of protein synthesis by cycloheximide blocked …
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Isolation and Structure Elucidation of Cytotoxic Natural Products from Suriname and Madagascar
… to be responsible for the bioactivity. A known triterpene, friedelin, was also isolated from the extract and found to be inactive. The structure of guttiferone A was determined by comparison of its NMR data to those found in the literature. The structure of guttiferone G was determined by …
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