Global ETD Search
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Showing 1 to 10 of 10 for “"Tristetraprolin"”.
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THE ROLE OF THE RNA-BINDING PROTEIN TRISTETRAPROLIN IN CERVICAL AND COLORECTAL CANCERS
… in the mRNA 3' untranslated region (3'UTR). Tristetraprolin (TTP) is an RNA-binding protein that plays a significant role in regulating the expression of ARE-containing mRNAs. Through its ability to bind AREs and target the bound mRNA for rapid degradation, TTP can limit the expression of a …
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ZFP36L3: a Unique Member of the Tristetraprolin Family of RNA-Binding Tandem Zinc Finger Proteins
<p>Members of the tristetraprolin (TTP) family of CCCH tandem zinc finger proteins bind to AU-rich elements in the 3' untranslated regions of certain cellular mRNAs, leading to their deadenylation and destabilization. Studies in knockout mice have demonstrated roles for three of the family members, …
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THE ROLE OF SELECTIVE MRNA DEADENYLATION IN THE HOMEOSTATIC CONTROL OF INNATE IMMUNE SIGNALING
… we identify that the RNA-binding protein, Tristetraprolin, and selective factors of the mRNA deadenylation machinery post-transcriptionally control interferon mRNAs both at steady state and post-stimulation. Loss of these mRNA decay factors leads to increased interferon levels and increased …
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Development Of New Therapy to Combat Tuberculosis Induced Inflammation
… effectiveness of two anti-inflammatory agents, Tristetraprolin (TTP) and FhHDM-1, to reduce lung inflammation during TB infection. A mouse model expressing active TTP was infected with M. tuberculosis. TTP mutant mice showed reduced lung inflammation during early infection. Next studies …
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The role of MK2/TTP pathway in regulating early development and innate immunity in zebrafish
… targets of MK2a is an RNA binding protein Tristetraprolin (TTP). bbp mutants lose the expression of YSL specific genes mxtx1 and mxtx2. Here, we show that these genes are regulated through their 3’untranslated region (UTR) by MK2a/TTP pathway required in the YSL during early zebrafish …
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Characterization of the instability elements present within the 3' UTR of the glutaminase mRNA in WKPT kidney cells
… of various RNA binding proteins. The addition of tristetraprolin (TTP) greatly enhanced deadenylation and degradation of GemARE-A6o mRNA, but only slightly stimulated the decay of GemGA-A60 mRNA. The turnover rate of GemGA-A60 was greatly enhanced in a cytosolic extracts of a clonal line of WKPT …
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The Regulation of ARE-Mediated mRNA Decay During Colorectal Tumorigenesis
… is largely understudied. The mRNA decay factor tristetraprolin (TTP), by virtue of its ability to bind AREs, promotes ARE-mediated mRNA decay by sequestering its target transcripts to P-bodies. Whereas TTP levels are low-to-undetectable in non-transformed cells, its expression is robustly …
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ZFP36L2 in Development and Adulthood: A Critical Regulator of Hematopoietic Stem Cell Homeostasis
<p>The tristetraprolin (TTP) protein family of RNA-binding proteins contains three widely expressed mammalian protein members: TTP (ZFP36), ZFP36L1, and ZFP36L2, all of which can regulate gene expression by binding to specific AU-rich sequences located in the 3'-untranslated regions (3’-UTR) of …
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Destabilization of IL-8 mRNA by Anthrax Lethal Toxin: Demonstration of the Requirement for TTP and Examination of its Cellular Interactions
Control of mRNA stability is an important aspect in the regulation of gene expression. A well studied signal for rapid transcript decay in mammalian cells is the AU-rich element (ARE), which is found in the 3’ untranslated region (UTR) of many labile transcripts. These sequence elements confer …