Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Triplex Forming Oligonucleotide"”.
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Synthesis of triplex-forming oligonucleotide conjugates of the anticancer drug temodal
… drugs temozolomide (Temodal) and mitozolomide to triplex-forming oligonucleotides (TFOs) is a potential way of targeting these alkylating agents to specific gene sequences to maximise site-selectivity. In this work, polypyrimidine TFO conjugates of both drugs were synthesised and targeted to …
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Novel nucleotide analogues for forming stable DNA triple helices
… DNA triple helices are formed by binding of a triplex-forming oligonucleotide (TFO) to a DNA duplex, via specific recognition of the individual base pairs in the target sequence.<br/>Mixed-sequence recognition of duplex DNA by TFOs is therefore an essential requirement for successful targeting. …
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Nucleotide Excision Repair, Crosslink Repair and Transcriptional Function of Xpa In Human Cells
… psoralen, and investigated repair of a triplex forming oligonucleotide (TFO)-directed psoralen ICL. A TFO-directed psoralen DNA ICL was constructed in closed-circular DNA. In NER proficient human cell extracts, incisions were detected on both strands of the damaged DNA 3’ to the psoralen …
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Therapeutic Gene Delivery to Human Pancreatic Islets for Treatment of Diabetes and the Effect of TFO on Liver Fibrosis Induced by Bile Duct Ligation
… in the fibrotic liver. We have therefore used a triplex forming oligonucleotide (TFO) against the type α1 (I) collagen and evaluated, whether it can attenuate liver fibrosis induced by common bile duct ligation (CBDL). There was a significant decrease in hydroxyproline levels in TFO‑treated …