Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Triplex DNA"”.
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Triplex dna receptor-gold nanoparticle conjugates for detection of oxidized dna base
Oxidations of DNA nucleobases are believed to be one of the sources of aging and some age-dependent disease, such as cancer. Human body have various mechanisms to repair damaged DNA and base-excision-repair is one mechanism for removing those oxidized nucleobases. This mechanism processes in the …
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Triplex formation as monitored by EPR spectroscopy and molecular dynamics studies of spin -probe -labeled DNAs
… into structural and dynamics properties of DNAs, proteins, and related systems. Spin labels have been extensively used to study the dynamics of oligonucleotides. An example of this is 5-membered ring nitroxide 5-(2,2,5,5-tetramethyl-3-ethynylpyrrolidine-1-oxyl)-uridine, which has been …
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Synthesis and detection of dna damage
The biological effects of DNA alkyl adducts are difficult to evaluate at the cellular level due to their instability. Synthesis of oligonucleotides that contain a single N7-alkylguanine has become a vital tool to achieve the above goal. However, the instability of N7-alkyguanines is not compatible …
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Specificity of triple helix formation
Triplex-forming oligonucleotides (TFOs) have been the subject of extensive<br/>research in recent years. They have potential applications in many areas; such as<br/>gene-based therapies, site-directed mutation and as biochemical tools. However,<br/>triplex technology has been hampered by several …
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G-Triple Chemiluminescent DNAZyme Based Biosensor for the Detection of Calcium(II) Ions in Solution and the Biological Functionality of Kinase Enzymes and the Rationale for their Employment as Promising Drug Targets, Substrate Specific Inhibition of P38alpha
G-quadruplex DNA structures, which are formed from planar stacks of G-tetrads and follow Hoogsteen hydrogen bonding, have recently received attention as recognition elements in bioanalytical assays. DNAzymes are functionally active, synthetic single-stranded DNA molecules that are capable of …