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Showing 1 to 20 of 36 for “"Triple Quadrupole"”.
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Polifenolok és származékaik feltérképezése hármaskvadrupól tömegspektrometriás módszerrel = Profiling polyphenols and their derivates with triple quadrupole mass spectometry
A polifenolok egyre jobban a figyelem középpontjába kerülnek, minél több kutatás és információ lát róluk napvilágot. Egyre inkább előtérbe kerülnek, mint olyan vegyületek, melyeknek kiemelkedő szerepe lehet az egészségmegőrzésben. Egyre bővülő ismereteink ellenére, vagy talán éppen amiatt, nagy …
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Electron Transfer and Other Reactions Using Atomic Metal Anions
… and reacted with various neutral reactants in a triple quadrupole mass spectrometer. The metal anions were formed via electrospray ionization of the metal-oxalate solutions and form in gas phase between the capillary and the first quadrupole. Neutral gas phase reactants investigated include NO, …
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Analysis of urinary lipid biomarker candidates from tuberculosis patients by multiple reaction monitoring
… for fragmentation by compound optimisation on a triple-quadrupole mass analyser, the data from which was used to build MRM assays. Liquid chromatography was optimised for these lipids and the MRMs were validated by spiking the lipid standards into a complex mixture. For the second part of the …
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Monolithically 3-D Printed, Quadrupole Mass Filter for High-Precision, Compact, CubeSat Mass Spectrometry
… monolithically 3Dprinted, hyperbolic, compact RF quadrupole mass filters. The devices were made using an advanced, multi-material extrusion printer. The devices are tested as RFonly collision cells for use in miniaturized triple quadrupole mass spectrometers and as quadrupole mass filters for …
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Computational Tools to Expand the Coverage of Metabolite Profiling via LC-MS/MS
… the design of large-scale triple quadrupole metabolite profiling experiments using the METLIN metabolite database is explored. Likelihoods of obtaining common fragmentation products from each structure in the database are estimated, and are then used to identify ensembles of …
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A new mass spectrometric assay of N8-acetylspermidine deacetylase and partial purification of the enzyme
… the selected reaction monitoring, SRM, using a triple quadrupole mass spectrometer.</p><p>Acetylputrescine was used for the first time as the substrate for the assay of N<sup>8</sup>-acetylspermidine deacetylase in lieu of N<sup>8</sup> -acetylspermidine. The crude enzyme extracted from rat …
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Proteomic insights into the modulation of foetal neurogenesis by the anti-retroviral efavirenz
… NES proteomic responses. Methods: A TSQ Vantage triple quadrupole mass spectrometer was employed to optimise targeted detection of efavirenz extracted from cultured cells and supernatant. Cells were cultured for 72 hours, incorporating a 24-hourly efavirenz treatment. Efavirenz concentration …
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THE IDENTIFICATION AND QUANTIFICATION OF ORGANOPHOSPHATE FLAME RETARDANTS IN RAW MATERIALS UTILIZED IN POLYURETHANE PRODUCTION
… specifically gas chromatography coupled with triple quadrupole mass spectrometry (GC-MS/MS). The examination of flame retardants containing organophosphates was completed utilizing various methods of analyses including electron ionization techniques along with various modes of detection. For …
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QuEChERS (Quick, Easy, Cheap, Effective, Rugged, and Safe) Extraction – Gas Chromatography for the Analysis of Drugs
… medicinal products using gas chromatography triple quadrupole mass spectrometry (GC-MS/MS) and high performance liquid chromatography (HPLC), the extraction of hormones from water using GC-MS/MS and GCxGC-TOFMS including a comparison of QuEChERS to solid phase microextraction (SPME) using …
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Development and Testing of a Rapid Multiplex Assay for the Identification of Biological Stains
… a case working laboratory prototype assay on a triple quadrupole mass spectrometer using single and mixed source casework-type samples.</p> <p>This work has the potential to significantly improve the accuracy and sensitivity of forensic serological testing. It will provide practitioners with …
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Marine microbial intact polar diacylglycerolipids and their application in the study of nutrient stress and bacterial production
… high throughput molecular ion independent triple quadrupole MS method for quantification. Using this analytical technique I examined the distribution of the nine most abundant classes of IPDAGs across the Mediterranean, and found that phospholipids as a percent of total IP-DAGs correlated …
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Development of Mass Spectrometric Methods for the Analysis of Components and Complex Interactions in Biological Systems
… determined by collision activation in a triple quadrupole mass spectrometer. A developed novel derived effective path length approach for predicting bond dissociation energies (BDE) for electrostatic complex's alkali metal adducts (Li+), and halide adducts (Cl-) of acylglycerols was …
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Measuring steroids from dried blood spots using tandem mass spectrometry to diagnose congenital adrenal hyperplasia
… chromatography (RP-UPLC) system combined with a triple quadrupole mass spectrometry using positive electrospray ionization (+ESI) mode. Each steroid was quantified using its deuterated or isotopically labelled internal standard. Calibration curve and quality control specimens were prepared in …
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Marine microbial intact polar diacylglycerolipids and their application in the study of nutrient stress and bacterial production
… high throughput molecular ion independent triple quadrupole MS method for quantification. Using this analytical technique I examined the distribution of the nine most abundant classes of IPDAGs across the Mediterranean, and found that phospholipids as a percent of total IP-DAGs correlated …
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The Occurrence and Fate of Steroid Hormones from Manure Amended Agriculture Fields
… were quantified using liquid chromatography and triple-quadrupole mass spectrometry following various sample extraction and clean-up strategies. The spatial and temporal distribution of manure-associated hormones in a manure surface applied agricultural field and adjacent stream was studied at …
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Synthesis and applications of functional magnetic polymer beads; synthesis and mass spectrometry analysis of model peptides
… induced dissociation experiments using a triple quadrupole mass spectrometer. It was found that the effective proton affinity of a cyclic peptide was significantly reduced compared to a linear analogue. The reduced proton affinity implies an increased lipophilicity of the peptide.</p>
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New Developments in Analytical Toxicology for the Investigation of Drug Facilitated Crime
… techniques are explored including single quadrupole, triple quadrupole and ion trap mass spectrometry.<br/><br/>In addition to developing assays for DFA cases, the versatility of this type of analytical chemistry is explored in two population studies. The first study evaluates alcohol …
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Novel customisable phases for micro solid-phase extraction and automated biological sample preparation
… (LC-OT-MS) and liquid chromatography quadrupole time of flight mass spectrometry (LC-QToF-MS). The IMER facilitated protein digestion within 10 minutes at room temperature and overall, observed lower sequence coverages and number of identified proteins compared to the conventional in …
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Pharmacocinétique comparative des curcuminoïdes avec ou sans oméga-3 : une étude en chassé-croisé randomisée
… curcuminoids concentration. The study was a triple-blind, randomized, crossover study where participants tested three formulations: 400 mg of curcuminoids powder extract, 400 mg of curcuminoids in rice oil and 400 mg of curcuminoids with 1 g MAG-OM3. Sixteen males and fifteen females consumed …
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The determination of β-endosulfan and endosulfan sulfate in human serum with dialkylphosphate metabolites as urinary markers using LC-MS/MS electrospray ionization
… of acetonitrile and 20 mM ammonium acetate. A triple quadrupole mass spectrometer equipped with an electrospray ionization source operating in the negative ionization mode was used for mass detection of all the analytes, employing multiple reaction monitoring as scan mode. Calibration standards …
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