Global ETD Search
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Showing 1 to 20 of 20 for “"Tripartite Motif"”.
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Analysen zu TRIM-Genen in Primaten
… Insbesondere bei getrennten Analysen von Tripartite Motif und B30.2-Domäne konnte festgestellt werden, dass bei TRIM21 das Tripartite Motif leichte Anzeichen einer positiven Selektion aufweist, während die B30.2-Domäne negativ selektioniert ist. TRIM22 dagegen weist innerhalb des …
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On the function of the interferon-inducible p53 target gene TRIM22
… gene TRIM22 (Staf50) is a member of the TRIM (TRIpartite Motif) family. The TRIM family is a family of RING (Really Interesting New Gene) proteins, defined through a tripartite motif, containing a RING-domain, one or two B-boxes and a Coiled-coil-domain. The TRIM proteins are involved in …
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Delineating the Mechanisms Through Which ZNF165 Supports Growth and Survival of Triple-Negative Breast Cancer
… zinc finger protein, ZNF446, and its associated tripartite motif protein, TRIM27, as obligate components of the ZNF165-SMAD3 complex that also support tumor cell viability. I found that while ZNF446 is bound to chromatin with the ZNF165-SMAD3 complex, TRIM27 alone is necessary for ZNF165 …
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The role of the human endonuclease VIII-like 1 and 3 in the repair of DNA replication blocking lesions
… to be ubiquitinated by the E3 ubiquitin-ligase, tripartite motif-containing protein 26 (TRIM26). Here, TRIM26 was identified as the major ubiquitin ligase for hNEIL3 through HeLa cell fractionation and in vitro ubiquitination assays. TRIM26 RNAi in U2OS cancer cells increased steady state levels …
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Activation of lipid kinase VPS34 by Rab GTPases
… binds on the “adaptor arm” of the complex to a tripartite motif made of VPS34 C2, VPS15 WD40 and FF domain. These interactions increase membrane recruitment and PI(3)P production of complex II specifically on early endosomes.
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Defining the role of endonuclease VIII-like 1 and 3 in the repair of interstrand crosslinks in cancer cells
… against NEIL3 and the E3-ubiquitin ligase tripartite motif-containing protein 26 (TRIM26), that has been shown to ubiquinate both NEIL1 and NEIL3 for proteasomal degradation and similar cell growth analyses performed using the MTT assay. Recombinant NEIL1 expression was confirmed by western …
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B-box Proteins in Light-regulated Development in Arabidopsis
… A-box) and a coiled-coil domain forming RBCC or tripartite motif (TRIM) proteins. Although RBCC proteins are absent in Arabidopsis, there are 32 proteins with N-terminal B-boxes. This thesis deals with the characterization of the B-box containing proteins, COL3, STH2 and STH3 and the study of …
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Dissecting The Interaction Between P53 and Trim24
… identified a novel binding partner of p53, Tripartite Motif 24 protein (TRIM24). TRIM24 is a member of the TRIM family of proteins, defined by their conserved RING, B-box, and coiled coil domains. Specifically, TRIM24 is a member of the TIF1 subfamily, which is characterized by PHD and Bromo …
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Characterising the interaction between TRIM28 and members of the Krab-ZFP family in transcription silencing
… remains largely unclear. TRIM28 belongs to the tripartite motif (TRIM) protein family with over 80 members in humans. They share a conserved N-terminal TRIM, also known as the RBCC as it consists of a RING domain, one or two Bbox domains and an antiparallel coiled-coil. In this study we aimed to …
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Trim24 As An Oncogene In The Mammary Gland
… binding partner and negative regulator of p53, Tripartite Motif protein 24 (TRIM24). TRIM24 is a multifunctional protein, which acts as a co-regulator of estrogen receptor, a histone reader with tandem PHD and Bromo domains, and a ubiquitin E3-ligase targeting p53 by its RING domain. TRIM24 is …
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Trim24 Promotes Mammary Tumor Development By Upregulating Metabolic Reducing Power
… to cancer cell survival and tumor progression. Tripartite motif-containing protein 24 (TRIM24) is an E3 ligase for p53, a nuclear receptor co-regulator, and a histone reader. Over expression of TRIM24 correlates with poor overall survival of breast cancer patients. Previously, our lab created a …
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Trim24 Orchestrates Metabolic Reprogramming and Emt In Breast Cancer
… oncogenic functions of an epigenetic regulator Tripartite Motif Protein 24 (TRIM24) coupled with metabolic reprogramming and epithelial mesenchymal transition (EMT) in breast cancer. TRIM24 was first established by our laboratory as a previously unknown negative regulator of p53 via its RING …
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Dissecting the Novel Roles of TRIM56 in Antiviral Innate Immunity
<p>The tripartite motif-containing (TRIM) proteins have emerged as a new class of host antiviral restriction factors, with several demonstrating roles in regulating innate antiviral responses. Of >70 known TRIMs, TRIM56 inhibits replication of bovine viral diarrhea virus, a ruminant pestivirus of …
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Functional Analysis of KAP1 Requirements for HIV-1 Transcription and Latency Reactivation
HIV-1 latency maintenance and reactivation are regulated by several viral and host factors. One such regulator is Krüppel-associated box (KRAB)-associated protein 1 (KAP1: also named TRIM28 or TIF1β). While initial studies have revealed KAP1 to be a positive regulator of latency reversal in …
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Identification of Trim24 Domain Essentiality In Primary Trim24Coe Carcinosarcoma Cell Lines
… discovered the epigenetic regulator function of Tripartite motif protein 24 (TRIM24) through its H3K4me0 and H3K23ac dual histone signature reader function, its negative regulatory effect on the p53 tumor suppressor, in addition to its shown oncogenic driving capacity on immortalized mammary …
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Identification of the metabolites responsible for colour stability from different lamb sires and elucidation of the underlying biochemical pathways : A thesis submitted in partial fulfilment of the requirements for the Degree of Doctor of Philosophy in Biochemistry at Lincoln University
… annexin 1, Beta 1- metal binding globulin, Tripartite motif family protein, galectin, Apolipoprotein A1, LIM domain binding 3 and myoglobin in differential relative abundance between the colour stable and labile groups. In metabolomics, using a normal phase hydrophilic interaction …
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Delineating Mechanisms of Signal-Induced RNA Polymerase II-Transcription
Signal-induced transcriptional programs regulate critical biological processes through the precise spatio-temporal activation of inducible gene programs. Understanding the dynamics by which RNA Polymerase II precisely induces transcription to activate these programs is important for dissecting the …
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Regulation of DHX16-mediated Innate Immunity by Unanchored Polyubiquitin
… present in viral RNA (vRNA) like the splicing motifs present in IAV vRNA segments. DHX16 requires its RNA helicase motif for direct, high-affinity interactions with specific vRNAs which trigger an association with unanchored K48-poly-Ub synthesized by the E3-Ub ligase TRIM6. These unanchored Ub …
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Genomic signatures of recent selection at HIV host susceptibility genes in a Central African human population
Multiple independent transfers of simian immunodeficiency virus (SIV) strains from chimpanzees to human populations produced the current HIV-1 pandemic. We hypothesized that Central African human populations may have been exposed to SIV prior to the current pandemic, and that previous local …