Global ETD Search
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Showing 1 to 2 of 2 for “"Trinucleotide repeat instability"”.
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Role of DNA Mismatch Repair in Disease-associated Trinucleotide Repeat Instability
Trinucleotide repeat (TNR) tract expansions in specific genes are known to cause numerous neurological and neuromuscular diseases. The mechanism of DNA instability is believed to involve the formation of slipped-repeat structures, and ongoing expansion requires the presence of functional mismatch …
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DNA Repair Deficiency in Huntington's Disease Fibroblasts and Induced Pluripotent Stem Cells
… disease (HD) –is a product of an expanded trinucleotide repeat (TNR) cytosine-adenine-guanine (CAG) sequence in exon 1 of the <em>huntingtin</em> <em>(HTT)</em> gene. The pathology of HD has been extensively researched; however, the mechanism by which the disease-causing TNR expansions …