Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"Trimethylamine-N-oxide (TMAO)"”.
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The Spectroscopic Characterization Of Newly Developed Emissive Materials And The Effects Of Environment On Their Photophysical Properties
… systems and a benchmark biological molecule trimethylamine N-oxide (TMAO).
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Chronic Treatment of TMAO Undermines Mouse Cardiac Structure and Function in a Sex-specific Manner
… studies have associated elevated levels of trimethylamine N-oxide (TMAO), a gut-derived metabolite, with adverse outcomes of CVD. As of today, TMAO's effects on cardiac structure and function are not well understood. In this study, both male and female TMAO-treated hearts showed functional …
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Transcriptional Regulation of Shewanella oneidensis Using Native TMAO-Inducible Promoters in a Plasmid-Free System
… that can be used to induce gene expression with trimethylamine N-oxide (TMAO). I demonstrate its use in a strain with a TMAO-inducible promoter driving mtr gene expression. qRT-PCR data indicate that the inducible system increases mtr gene expression when the cells are exposed to TMAO. …
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Noncovalent Interactions Involving Microsolvated Networks Of Trimethylamine N-Oxide
… networks with the important osmolyte trimethylamine N-oxide (TMAO). Vibrational spectroscopy, in this case Raman spectroscopy, is used to interpret the effects of noncovalent interactions by solvation with select hydrogen bond donors such as water, methanol, ethanol and ethylene glycol …
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A taxonomic study of the genus Campylobacter
… minimal medium (MM), anaerobic growth in 0.1% trimethylamine-N-oxide (TMAO), H₂S production in Sulfide-Indole-Motility (SIM) medium, or on triple sugar iron (TSI) agar slants, hippurate hydrolysis, aerobic growth on agar plates, a requirement for H₂ or formate for microaerophilic growth or H₂ …
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The Impact of Dietary Fat and Phosphatidylcholine on Increased Trimethylamine-N-oxide Levels
Trimethylamine-N-oxide (TMAO) is an important biomarker of atherosclerosis. TMAO is the product of a hepatic conversion of trimethylamine (TMA). Releasing of TMA moieties is dependent on the adaptation of the gut microbiota to dietary TMA containing substrates such as phosphatidylcholine (PC), …
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The Elasmobranch-Microbe Relationship: Trimethylamine n-oxide Synthesis, Urea Hydrolysis, and Microbe-Osmolyte Interactions in the Atlantic Stingray, <i>Dasyatis sabina</i>
… of nitrogenous compounds, primarily urea and trimethylamine n¬-oxide (TMAO). Despite the abundance of these plasma osmolytes, it is notable that elasmobranchs appear to lack urease and TMA oxidase (Tmase), enzymes that scavenge urea-nitrogen and synthesize TMAO, respectively. However, urease …
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Investigation of Microbiome Metabolites and Mitochondrial Function in a model of Non-Alcoholic Fatty Liver Disease
… non-alcoholic fatty liver disease (NAFLD). Trimethylamine N-oxide (TMAO) and phenylacetic acid (PAA) are microbiome-derived metabolites that have been associated with early onset of NAFLD. Hypothesising that these metabolites contribute to lipid deposition in the liver by altering hepatic …
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Trimethylamine-N-oxide reduction by alteromonas spp.
Trimethylamine-N-oxide (TMAO) is a nitrogenous compound widely distributed in marine fish and invertebrates. It has long been known that TMAO is reduced by bacteria during the post mortem spoilage of iced marine fish, but the mechanism involved and the physiological role have remained unknown. …
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Effects of Trimethylamine N-Oxide on Mouse Embryonic Stem Cell Properties
Trimethylamine N-oxide (TMAO) is a metabolite derived from dietary choline, betaine, and carnitine via intestinal microbiota metabolism. In several recent studies, TMAO has been shown to directly induce inflammation and reactive oxygen species (ROS) generation in numerous cell types, resulting in …
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Gut Microbiota-Generated Trimethylamine N-Oxide and Cardiometabolic Health in Humans
… microbes metabolize dietary sources to release trimethylamine (TMA). TMA is absorbed and then oxidized by flavin monooxygenase 3 (FMO3) to form trimethylamine N-oxide (TMAO). Elevated TMAO is associated with increased risk of cardiovascular disease and type 2 diabetes; however, the causal nature …
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Investigations into the roles of bacterial TorD family chaperone proteins
… DmsA - the catalytic subunit of dimethyl sulphoxide (DMSO) reductase. TorD assists in the assembly of the catalytic subunit of trimethylamine N-oxide (TMAO) reductase, TorA.<br/> Work presented in this thesis has demonstrated that the interaction between S. Typhimurium DmsD and YnfE requires a …
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Gut Microbiota-Generated Trimethylamine-N-oxide and Cardiometabolic Health in Healthy Adults
… diets. Gut microbiota metabolize choline to trimethylamine (TMA) which circulates and is oxidized in the liver to form trimethylamine N-oxide (TMAO). As a result, ingestion of PC or choline could increase levels of TMAO. Preclinical studies indicate a role of TMAO in the development of …
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Probiotic Supplementation, The Gut Microbiota, and Cardiovascular Health
… and increased production of the pro-atherogenic, trimethylamine-N-oxide (TMAO). Together, these changes are hypothesized to accelerate CVD progression. Conversely, administration of gut microbiota modulating agents, such as antibiotics and probiotics, attenuate high fat feeding induced CVD in …
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Roles of cosolvents on protein stability
… probe the role of two major cosolvents, urea and trimethylamine N-oxide (TMAO) at atomic level. Urea is widely used as a denaturant in the lab to destabilize native protein conformations. However, the atomic mechanism of this molecule remains a question of debate. To unravel its molecular …
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The effect of macromolecular crowding on the structure of the protein complex superoxide dismutase
… crowding on the size of a protein complex, superoxide dismutase (SOD). Crowding was induced using 400 MW polyethylene glycol (PEG), triethylene glycol (TEG), methyl-alpha-glucoside (alpha-MG) and trimethylamine N-oxide (TMAO). Parallel small angle neutron scattering (SANS) and small angle X-ray …
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Kinetic Characterization of the Coupled Folding and Binding Mechanism of Bacterial RNase P Protein: an Intrinsically Unstructured Protein
… the folding and binding are tightly coupled. Trimethylamine-N oxide (TMAO), an osmolyte that stabilizes the unliganded folded form of the protein, enabled us to study the folding process of P protein in the absence of ligand. Transient stopped-flow kinetic time courses at various final TMAO …
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Health impacts and dietary composition of Paleolithic and Australian Guide to Healthy Eating Diets in Australia
… with a Paleolithic dietary pattern. Serum trimethylamine-N-oxide (TMAO) arises mainly from colonic fermentation and hepatic conversion of animal protein and is positively associated with cardiovascular disease, but changes to RS intake may alter concentrations. With available literature on …
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Investigating the Influence of Fresh and Aged Garlic Extracts on the Biosynthesis of Trimethylamine N-Oxide
… (CVD) risk, possibly by reducing the risk marker trimethylamine-N-oxide (TMAO). TMAO production in humans is largely influenced by the metabolic activity of the intestinal bacteria on dietary precursors including L-carnitine. Dietary supplementation of bioactive garlic phytochemical allicin has …
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