Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"Triggered release"”.
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PH-responsive polymeric materials for encapsulation and triggered release
… actives, a controllable method is needed to release the materials at the desired time, location, and rate. To address these challenges, scientists look to stimuli-responsive polymers as a solution because polymers can be designed with tailored properties thanks to advancement in polymer …
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Developing photoresponsive lipid nanoparticles for the triggered release of small molecules
… system responded to a visible light trigger but released insufficient cargo. The cholesterol-DASA conjugate was hypothesized to create further disruption within the DOPC liposome, triggering a greater amount of release upon its photoswitch, but unfortunately the opposite was observed. However, …
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Light-triggered release of bioactive compounds from HA/PLL multilayer films for stimulation of cells
… time as reservoirs for bioactive molecules to be released in a controlled manner. UV light is used to trigger the release of the stored ATP with high spatio-temporal resolution. Both physico-chemical (competitive intermolecular interactions in the film) and biological aspects (cellular response …
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Redox-active Liposome Delivery Agents With Highly Controllable Stimuli-responsive Behavior
… liposomes for the containment and subsequent triggered release of encapsulated cargo. Development of said system required (1) the synthesis and then characterization of various simple quinones and quinone propionic acids by cyclic voltammetry and X-ray crystallography and (2) the preparation …
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Medical Engineering Across Length Scales Using Structural and Analytical Biomaterial Nanotechnology
… a triggerresponsive DNA building block to render triggered-release hybrid nanocarriers. By the addition of a nucleic acid input, the contraction of a DNA hairpin was induced. Functional studies of the DNA coat mobility indicate, that this induces structural changes in the DNA assembly which …
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Novel techniques for microencapsulation of probiotic bacteria
… cells composite microcapsules programmed to release the cells upon change of pH in a narrow range. This was achieved by either spray drying or sprays co-precipitating dispersion of yeast cells in aqueous solution of ammonium shellac doped with a pH-sensitive polyelectrolyte. We also …
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Amorphous solid dispersion effects on in vitro solution concentrations of quercetin
… (CASub) to achieve stability and provide pH-triggered release. In addition, polyvinylpyrrolidone (PVP) containing CASub and CCAB blends were prepared to further promote enhanced dissolution. The ASD employing 10% quercetin in 20% PVP:70% CASub was most successful at enhancing the solution …
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Stimuli-responsive microcapsules for self-protecting and self-healing material systems
… are formed with hydrophobic cores. The acid-triggered release of Eudragit and cPPA microcapsules containing an oil core is demonstrated. Tunable, monodisperse double emulsion templates with an aqueous core are formed with sizes ranging from 295 µm to 1200 µm. The double emulsion templates are …
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Specific ion effects on transient polymers: a new strategy for programmable microcapusles
… transform from macromolecules to small molecules triggered by predefined environmental stimuli. Distinct from traditional degradable polymers, transient materials undergo domino like chain unzipping reactions, leading to controlled and complete depolymerization upon one cleavage. Taking advantage …
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Biologically Inspired Design of Protein-Silica Hybrid Nanoparticles for Drug Delivery Applications
… targeting ligands and that enable controlled release. The overall aim of this work is to engineer a hybrid nanomaterial system comprised of protein and silica and to characterize its potential as an encapsulating drug carrier. The synthesis of silica, an attractive nanomaterial component …
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Towards next-generation degradable polymers via double amplification
… was explored in the context of developing novel triggered release systems with very rapid responses. The system explored in this work was designed to trigger in response to sunlight, using long-wave UV-sensitive photoacid generators as initiators, and acid amplifiers as the bulk phase. …
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Cellulose Esters and Cellulose Ether Esters for Oral Drug Delivery Systems
… as high Tg, recrystallization prevention and pH-triggered release due to the free -COOH groups. Rifampicin (Rif), Ritonavir (Rit), Efavirenz (Efa), Etravirine (Etra) and Quercetin (Que) cellulose ester ASDs were investigated in order to increase drug solubility, prevent release at low pH and …
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Synthesis and Characterization of Redox-Sensitive Polymer and Prodrug for Targeted Drug Delivery
… application was simulated through in vitro redox-triggered release of paclitaxel from polymeric nanoparticles. SN-38 (7-ethyl-10-hydroxy-camptothecin), a potent metabolite of irinotecan (CPT-11), has been extensively investigated in the past for direct usage in order to fully exploit its cytotoxic …
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Design and development of stimuli-responsive materials: pH sensitive polymersomes and poly(olefin sulfone)s
… pH-responsive materials. Materials which can be triggered with pH have a variety of applications in biological and industrial fields. This thesis is split into two main parts: 1) the development of acid-triggerable covalently-crosslinked polymersomes and 2) the design and synthesis of base-, …
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Physical and practical limits of a biomolecular control system using nanoparticles and electromagnetic field irradiation
… on the quantification of a fs-pulsed laser triggered release mechanism that actuates activity of the molecules released from NPs. The release mechanism is governed by NP surface chemistry. The operating window for the critical parameters governing release including NP properties and laser …
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Structural and Functional Studies of C2-Domain Proteins Involved In Neurotransmitter Release
Neurotransmitter release is mediated by synaptic vesicle exocytosis at presynaptic nerve terminals. This process is extremely fast and strictly regulated by the intracellular Ca2+ concentration. To achieve this exquisite regulation, many proteins are involved. The central fusion machinery includes …
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Nuclear-Targeted Gold Nanoparticles Enhance The Effects of Radiation Therapy With and Without Liposomal Delivery
… the tumor. Non-invasive thermal stimulation then releases the nanoparticle load at the intended of site of cellular uptake. The nuclear targeting of gold nanoparticles enhances the local effects of radiation via generation of short-range secondary electrons in the proximity of the DNA in …
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Self-assembly of inorganic nanoparticle amphiphiles for biomedical applications
… hybrid vesicles were demonstrated for both light-triggered release of payload and magnetic resonance imaging. Particularly, the magnetic manipulation of vesicles to specific location can be used to enhance the photothermal effect of the vesicles in cancer imaging and therapy. Finally, we reported …
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Strategies for incorporating functional block copolymers into polyelectrolyte multilayer coatings
… of nanotube structures; T-enabled loading and release of proteins; as well as their tunable disintegration, useful for triggered release, is discussed and demonstrated. On a separate note, the utility of inorganic nanoparticle LbL assembly in creating conformal thin UV anti-reflection coatings …
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Growth of Opportunistic Pathogens in Domestic Plumbing: Building Standards, System Operation, and Design
… in large building systems. This likely triggered two unprecedented clusters of Legionnaire's disease. In pilot-scale systems, copper released from copper pipes, but not dosed as soluble cupric, triggered release of >1,100 times more H2 into the water due to deposition corrosion. The …
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