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Showing 1 to 20 of 26 for “"Trigeminal ganglion"”.
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FROM A PLACODE PROGENITOR PLATFORM TO A TRIGEMINAL GANGLION ORGANOID: MODELLING SENSORY DEVELOPMENT AND FUNCTION IN VITRO
The trigeminal ganglion (TG) is composed of peripheral sensory neurons which transmit pain, temperature and touch information from the face to the brain. Developmentally, it originates from an ectodermal population named pre-placodal ectoderm, which is marked by the expression of the transcription …
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IDENTIFICATION OF KEY MOLECULES IN PLACODE-DERIVED NEURONS THAT COORDINATE CHICK TRIGEMINAL GANGLIOGENESIS
The trigeminal nerve is the largest of the cranial nerves, possessing three main branches (ophthalmic, maxillary, and mandibular) and relaying sensations of pain, touch, and temperature from the face and head to the brain. Cell bodies of this nerve are positioned in the trigeminal ganglion, which …
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Effect of Intranasal Delivery of Carbon Dioxide on Trigeminal Ganglion Neurons: Inhibition of Neuron-Glia Gap Junction Communication and Neuropeptide Secretion
… diseases is not well understood. Activation of trigeminal nerves, release of CGRP, and neuron-glia interactions through gap junctions in trigeminal ganglion are implicated in the pathology of migraine and allergic rhinosinusitis. The goal of this study was to determine whether administration of …
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Regulation of Neuropeptide Y, Vasoactive Intestinal Polypeptide, and Their Receptors in Trigeminal Ganglion Neurons and Glia in Response to Adjuvant-Induced Inflammation
<p>Activation of trigeminal nerves is involved in temporomandibular joint (TMJ) inflammation and pain transmission. Neuropeptide Y (NPY), vasoactive intestinal polypeptide (VIP), and their receptors have been implicated in the underlying pathology of temporomandibular joint disorders. The goal of …
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Estrogen Signaling in Trigeminal Nociception
… We used an established model of inflammatory trigeminal pain, injection of Complete Freund's adjuvant (CFA) into the masseter muscle, to determine whether ERK activation may play a role in hormone-related trigeminal pain disorders. We measured withdrawal responses to stimulation of the …
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Evaluation of Anti-Migraine Drugs in an in Vivo Rat Model of Chronic Migraine
… somatic symptoms. Prolonged sensitization of the trigeminal system, which is implicated in CM, is comprised of peripheral primary trigeminal ganglion neurons that provide sensory innervation of the head and face and second order neurons in the spinal trigeminal nucleus (STN). The goal of my study …
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Identification of Connexins in Facilitating Neuron-Satellite Glial Cell Signaling in Trigeminal Ganglia
Activation of trigeminal nerves in response to an inflammatory stimulus causes increased communication between neurons and surrounding satellite glial cells via gap junctions in the trigeminal ganglion (TG). The goal of this study was to identify the gap junction proteins, or connexins (Cxs), in …
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THE ROAD LESS TAKEN: CHARACTERIZING THE TRIGEMINAL NERVE ROUTE OF NEUROINVASION BY RESPIRATORY SARS-COV-2
… agent SARS-CoV-2 invades the brain, the trigeminal nerve may serve as an additional, yet often overlooked, neuroinvasive route. We initially conducted a pilot study using AC70 human ACE2 transgenic mice, which were subjected to intranasal inoculation of SARS-CoV-2, to investigate the …
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Evaluating the Role of the Ocular Surface Microbiome in Dry Eye Disease Mediated Neural Dysregulation
… abnormalities which are regulated by the corneal-trigeminal ganglion pathway. An important contributor to ocular homeostasis is the ocular surface microbiome (OSM). In DED, the OSM has been postulated to be dysregulated, exhibiting a loss of diversity and increase in bacterial abundance. Along …
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The Role of FGFR4 in Trigeminal Placode Cell Development
<p>In vertebrate embryos, the ophthalmic trigeminal (opV) placode contributes sensory neurons to the trigeminal ganglion during development of the peripheral nervous system. FGFR4 is expressed transiently in the trigeminal placode as cells undergo an epithelial-mesenchymal transition and begin to …
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A Structural Basis for Neuropathic Pain Syndromes Associated with Mutations in Nav1.7
… specific isoforms of Navs present in dorsal root ganglion (DRG) and trigeminal ganglion (TG) sensory neurons. Nav1.7 is the most abundantly expressed isoform in DRG and TG neurons, and an isoleucine to valine mutation at residue 136 in the voltage- sensing domain (VSD) results in the disease, …
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Effects of Single and Dual Orexin Receptor Antagonists on Trigeminal Nociception
… perception. This disorder is mediated by the trigeminal nerve, which provides sensory innervation to the face, scalp, and meninges. Migraine pain is conveyed to the brain via the trigeminothalamic tract, which relays nociceptive signaling from primary nociceptors to the hypothalamus. Orexins …
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Secondary Traumatic Stress Promotes Peripheral Trigeminal Nociceptor Sensitization
… Sensitization and activation of peripheral trigeminal neurons that provide sensory innervation to most of the head and face is implicated in migraine pathology. The most commonly cited risk factor for migraine is stress, and in particular, primary traumatic stress directly to the individual. …
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The Role of Wnt Signaling in Development of the Ophthalmic Trigeminal Placode.
… system. The development of the ophthalmic trigeminal (opV) placode, which gives rise only to sensory neurons of the ophthalmic lobe of the trigeminal ganglion, is a well-studied model of sensory neuron development. While key differentiation processes have been characterized at the tissue …
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Toll-like receptor expression and signalling in rat trigeminal neurons: Consequences for oral infection and mechanisms of orofacial pain.
… poorly understood, particularly within the trigeminal system. The main objectives of this thesis, therefore, were to better characterise the expression and functional consequences of activation of neuronal TLRs in the setting of orofacial pain. A detailed, quantitative description of TLR4, …
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Characterization of an in Vivo Model of Temporomandibular Joint Inflammation
Activation of trigeminal nerves is involved in temporomandibular joint (TMJ) inflamation and pain transmission. The proinflammatory molecule nitric oxide (NO) and protons are implicated in the underlying pathology of temporomandibular joint disorders. The goal of this study was to investigate gap …
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Development of the Mesencephalic Trigeminal Nucleus in the Zebrafish
The mesencephalic trigeminal nucleus (MTN) forms part of the monosynaptic trigeminal circuit and is essential for eating and suckling in mammals. Little is known about how the MTN forms. For this thesis I aimed to elucidate the molecular and cellular basis of MTN development. I also aimed to …
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The Role of Pax3 in Neuronal Differentiation of the Ophthalmic (OpV) Trigeminal Placode and Neural Tube during Chicken Embryonic Development
… at understanding tissue interactions involved in trigeminal ophthalmic (opV) placode development. While Pax3 expression coincides with opV neuron specification, the function of Pax3 in these cells has not previously been investigated. Splotch mutant mice (which lack Pax3) have a reduced trigeminal …
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Neural Crest Contributions to Dental Pulp Stem/Progenitor Cells and Craniofacial Structures: Alveolar Processes, Tongue and Temporomandibular Joint
… nerve ganglia in the tongue cross section, trigeminal ganglion, connective tissue in the palate, alveolar bone, Meckel’s cartilage, hyoid bone, hyaline cartilage and the area of TMJ demonstrated the highly positive staining.</p> <p> <strong>Conclusions:</strong> This study suggests that: (1) …
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