Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Trifluoromethyl ketone"”.
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Synthesis of Delta(3)-Imidazolines as Latent Forms of Peptidyl Trifluoromethyl Ketones
Many trifluoromethyl-substituted imidazolines were efficiently synthesized directly into larger peptides, by use of carbamate-protected amino acid fluorides as the initiator of the dipolar cycloaddition. The imidazolines then functioned as a protecting group for the trifluoromethyl ketones during …
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Fluoromethyl ketone prodrugs: Potential new insecticides towards Anopheles gambiae
… studies demonstrate that tri- and difluoromethyl ketones can potentially inhibit An. gambiae AChE (AgAChE). These compounds inhibit the enzyme by making a covalent adduct with the catalytic serine of AChE. Trifluoromethyl ketones however are poor inhibitors of the G119S resistant mutant of AgAChE. …
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Development of decarboxylative strategies towards the synthesis of fluorinated pharmacons
Fluoro(oxo) functional groups, such as trifluoromethyl ketones, difluoromethyl ketones, and trifluoroethanols, have emerged as desirable motifs in medicinal chemistry for the fine tuning of pharmacokinetic properties. Over the past few decades, fluoro(oxo) diversity has been accessed through …
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Esterase 2-oligodeoxynucleotide conjugates as enzyme reporter for electrochemical detection of DNA and identification of bacterial species
… by a single-step affinity chromatography with trifluoromethyl ketone as a ligand and covalently conjugated to a 5’-amino modified oligodeoxynucleotide. The purified conjugate served as a reporter enzyme for electrochemical detection of nucleic acids. Being an optimal substrate, …
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Biochemical analysis of the interaction between transfer ribonucleic acid and exportin-t
… directly. Exportin-t-esterase, immobilized to trifluoromethyl ketone (TFK) modified mica surface, showed a diameter of 15 ± 2 nm. After binding tRNA and Ran•GppNHp, the diameter of the complex somewhat increased to 16 ± 2 nm.
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Caracterización de las vías de la fosfolipasa A_2 en procesos de neurodegeneración inducidos por estrés oxidativo en la retina bovina
… cetona (ATK, del inglés arachidonoyl trifluoromethyl ketone –inhibidor de la cPLA2–), bromoenol lactona (BEL, del inglés bromoenol lactone –inhibidor de la iPLA2–) e YM 26734 (inhibidor de la sPLA2). La pre-incubación de las retinas con ATK provocó una disminución de los niveles de …