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Showing 1 to 20 of 102 for “"Trifluoromethyl"”.
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Matrix Isolation of Aryl(trifluoromethyl)carbenes, Heteroaryl(trifluoromethyl)carbenes and Phenylbis(trifluoromethyl)carbenes
We have isolated and studied 2-naphthyl(trifluoromethyl)carbene, 1-naphthyl(trifluoromethyl)carbene, 4-pyridyl (trifluoromethyl)carbene, 2-pyridyl(trifluoromethyl)carbene, 3-pyridyl (trifluoromethyl)carbene, 3-bromo-5-pyridyl(trifluoromethyl)carbene, meta-phenylbis(trifluoromethyl)carbene and …
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Trifluoromethyl ketones: Potential insecticides towards Anopheles gambiae
… In vitro assay studies have shown that trifluoromethyl ketones (TFK's) are potent inhibitors of An. gambiae AChE (AgAChE), that inhibit the enzyme by making a covalent adduct with the catalytic serine of the enzyme. However research in the Carlier group has shown that trifluoromethyl …
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Diastereomeric Interactions of Sulfoxides, Lactones and Aryl Trifluoromethyl Carbinols
Made available in DSpace on 2014-12-13T20:10:02Z (GMT). No. of bitstreams: 1 7709188.pdf: 3101030 bytes, checksum: 861440f74c5e31ae7326a4ba5123666b (MD5) Previous issue date: 1976
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Analysis of the microwave spectrum of the bis-trifluoromethyl nitroxide
… spectrum of the stable free radical bis-trifluoromethyl nitroxide was analyzed in the 20 to 26.5 GHz region. 39 transitions have been assigned. The rigid rotor rotational constants determined by calculation of the hypothetical unsplit rotational transitions are A= 2256.94 MHz, B= 1056.08 …
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The attempted synthesis of 3-trifluoromethyl-2,5-dihydrothiophene 1,1-dioxide
… means of a modified Diels-Alder reaction of 2- trifluoromethyl-1,3-butadiene (II) and sulfur dioxide. Evidence is given to support the structure of the product of the Diels-Alder reaction as that assigned to I.
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Photochemistry of 5-Membered Heteroaryl(trifluoromethyl)carbenes in Low Temperature Matrices
… the photochemical reactions of 3-benzothienyl(trifluoromethyl)-, 3-N-methyl-indolyl(trifluoromethyl)-, 2-N-methyl-indolyl(trifluoromethyl)-, benzo-thiazolyl(trifluoromethyl)-, and benzoxazolyl(trifluoromethyl)carbenes in low temperature N2 matrices. The 3-benzothienyl(trifluoromethyl)carbene …
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Direct fluorination : a new method for the synthesis of trifluoromethyl compounds.
Thesis. 1977. Ph.D.--Massachusetts Institute of Technology. Dept. of Chemistry.
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Synthesis of Delta(3)-Imidazolines as Latent Forms of Peptidyl Trifluoromethyl Ketones
Many trifluoromethyl-substituted imidazolines were efficiently synthesized directly into larger peptides, by use of carbamate-protected amino acid fluorides as the initiator of the dipolar cycloaddition. The imidazolines then functioned as a protecting group for the trifluoromethyl ketones during …
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Carbon-trifluoromethyl bond forming reactions and palladium-catalyzed cyanation of (hetero)aryl halides
Chapter 1 Nucleophilic trifluoromethyl sources were systematically examined in stoichiometric palladium experiments to determine the most efficient class of reagents for transmetallation. In conjunction with reductive elimination studies, this led to the development of the first system for the …
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Development of Novel Methods for the Installation of Trifluoromethyl/Boryl and 1,2,4-Oxadiazole Moieties
There are immense efforts to install the trifluoromethyl group (CF3) into organic molecules since it significantly affects reactivity, as well as the biological and pharmaceutical properties of the molecule. The α-trifluoromethylacrylates are useful synthetic intermediates for the synthesis of …
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The Development of Palladium and Cobalt-Catalyzed Methods for the Syntheses of alpha-Trifluoromethyl and Alkyl Amines
… synthesis. Amongst these chiral amines, a-trifluoromethyl and alkyl amines are an important subclass that have been sought after because of their relevance in drug discovery. With respect to a-trifluoromethyl amines, the role of fluorine in altering lipophilicity, influencing pKa, and …
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Synthesis, pharmacological and physicochemical profiling of antimalarial and antischistosomal N-aryl 3-trifluoromethyl pyrido [1,2-α] benzimidazoles
… activities of N-aryl substituted 3- trifluoromethyl PBI derivatives. Additionally, structure-property trends of generated analogues have been delineated. The evolvable nature of the structure-activity and structureproperty relationship trends make these compounds appealing as …
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Design and Synthesis of 8-Trifluoromethyl-Substituted Heterocyclic Small Molecule Mitochondrial Uncouplers for the Treatment of Metabolic Diseases
… We report the discovery of N-substituted 8-trifluoromethyl-9H-purin-6- amines where lead compound SHK1112218 was identified as a highly potent mitochondrial uncoupler. Additionally, in an obesity reversal study in mice, treatment with lead compound SHK589 was observed to decrease body fat …
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Synthesis of 4-(trifluoromethyl)azetidin-2-one building blocks and their transformation into novel CF3-substituted amines and heterocyclic systems
… on the other hand, β-lactams bearing a trifluoromethyl group comprise interesting entities for the construction of novel targets with promising bioactivities. In this PhD thesis, the preparation and deployment of 4-trifluoromethyl-β-lactams as new building blocks toward a diverse set of …
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The Synthesis and Reactions of 2-Diazo-4,5-Bis(trifluoromethyl)imidazole, a Carbene Precursor to Stable Ylide and Hypervalent Compounds
The synthesis of 2-diazo-4,5-bis(trifluoromethyl)imidazole is discussed. An azo-linkage is used as a masked amine source in a fluorination reaction in which carboxylic acids are converted to trifluoromethyl groups. The azo compound is then hydrogenolyzed to the diazo compound precursor, …
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The Electronic Structure of The Trifluoride Ion and a New Synthesis and Reactions of 3-Chloro-1,2,3-Tris (Trifluoromethyl) Cyclopropene (Metallatetrahedrane, Molybdenum, Hypervalent)
The electronic structure of the hypervalent trifluoride ion has been calculated at the ACCD (approximate coupled clusters with doubles substitution) level. The ion was calculated to be symmetric (point group D(,(INFIN)h)) and stable with respect to F('-) and F(,2) by 11 kcal/mol.
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The electronic absorption spectra of di- and tri-arylmethane dyes containing fluorine
… Hydrol Blue has been synthesised containing meta-trifluoromethyl groups. Such dyes have not been previously prepared because of earlier difficulties encountered in synthesising N.N-dimethyl-2-tri -fluoromethylaniline. A synthetic route to this compound has now been established. The preparation of …
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