Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"Trichostatin A"”.
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An improved synthesis of the HDAC inhibitor trichostatin A
… treatment of advanced cutaneous T-cell lymphoma. Trichostatin A is one of the most potent known naturally-occurring inhibitors of histone deacetylase. Unfortunately for researchers, the syntheses that have been reported are both long and difficult, which leads to a low overall yield and therefore …
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Butyrat moduliert die Expression der Nicht-Histon-Proteine HMGA1, HMGN1 und HMGN2 in humanen Adenokarzinomzellen des Kolons und des Magens
… Butyrat und der Histon-deacetylase-Inhibitor Trichostatin A die Expression von HMGA1 in humanen Adenokarzinomzellen des Gastrointestinaltraktes modulieren. Butyrat-Konzentrationen von 2mM und 4mM führten erstmals nach 24-stündiger Inkubation zu einer deutlichen Reduktion der mRNA-Expression …
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Epigenetische Beeinflussung der Proliferation, Expression von Matrix-Metalloproteinasen, Migration und Invasion von Harnblasenkarzinomzelllinien
… und Histondeacetylaseinhibitoren wie Trichostatin A, stellen potenzielle therapeutische Optionen für die Behandlung maligner Tumoren dar. In dieser Studie wurde deren Wirkungsweise an vier biologisch unterschiedlichen urothelialen Karzinomzelllinien untersucht. Die epigenetische …
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Genomic Analysis of Chemo-Resistance to HDAC inhibitor in Gastric Cancer cells
… cancer cell lines with multiple HDACi compounds (trichostatin A, SAHA and MS275), we identified two distinct classes of lines exhibiting either HDACi sensitivity or resistance. Genomic comparisons between the sensitive and resistant classes using two independent microarray platforms identified …
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Tumour chemo sensitivity assays: an investigation into the susceptibility of cells to chemotherapeutics
… drug trials, the histone deacetylase inhibitor, trichostatin A. To investigate this resistance further, MALDI-MS was performed on the chosen melanoma cell lysates. The results demonstrated that good quality proteomic data could be achieved from cell lines and that it is possible to generate …
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MECHANISM OF TRANSCRIPTIONAL REPRESSION OF MMP-9 BY INTERFERON-β
… in the presence of a type 1 HDAC inhibitor, Trichostatin A (TSA). ChIP analysis shows that IFN-beta induced HDAC1 recruitment to the MMP-9 promoter is lost when the AP-1 binding site is inactivated by a point mutation. Altogether, these results establish that the repression of MMP-9 …
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Spinal Muscular Atrophy: Evidence of a Multi-System Disease
… modulation via the histone deacetylase inhibitor trichostatin A. We also identify dramatic changes in immune organs in mouse models of SMA, which could impact susceptibility to infections. Furthermore, we establish the presence of important defects in fatty acid homeostasis in the liver and plasma …
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Analyse des in vivo Differenzierungspotentials humaner leukämischer Zellen sowie humaner und muriner neuraler Stammzellen
… neurale Stammzellen (NSZ)wurden in vitro mit Trichostatin A (TSA) und 5’-Aza-2’-deoxycytidin (AzaC)inkubiert und anschließend in murine Blastozysten bzw. adulte NOD/SCID Mäuse transplantiert. In dem Versuchen konnte gezeigt werden, dass humane leukämische Zellen nach Injektion in murine …
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Mechanisms of mTOR Signal Transduction Regulating Cell Growth and Differentiation
… mRNA level, which is rescued by HDAC inhibitor trichostatin A (TSA). Concurrently, anti-miR-1 LNA also inhibits myotube fusion, which could be rescued by either introducing recombinant follistatin, or inducing the expression of endogenous follistatin through TSA. These data strongly support an …
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Identification of substrate-selective histone deacetylases and their inhibitors that mediate HER2 transcript stability
… Studies conducted using pan-HDAC inhibitors like Trichostatin A (TSA) as well as various class-selective HDAC inhibitors, examine their comparative influences on the association of proteins with either the ribosome or polyribosome translational machinery, protein levels and acetylation status …
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Epigenetic Modification of Phenotype in Intestinal Smooth Muscle Cells
… unknown. Repeated passage ISMC were treated with trichostatin A (TSA) and 5-azacytidine (AZA), which inhibit enzymes that deacetylate histones and methylate DNA, respectively, and the outcomes on phenotype were assessed. TSA and AZA treatment decreased the enhanced growth response of repeated …
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Uncovering The Zeb1 Interactome to Identify Novel Regulators of Metastatic Non-Small Cell Lung Cancer
… Through treatment with class I HDAC inhibitors Trichostatin A, we identified that ZEB1 homodimerizes and determine that acetylation at lysine residue 811 regulates this association. Furthermore, we identify the NuRD complex as a novel ZEB1 co-repressor and the Rab22 GTPase activating protein …
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Human Organotypic Retinal Cultures as a model of human retinal ganglion cell degeneration in glaucoma. Effects of epigenetic regulation and mesenchymal stem cell derived growth factors.
… by the histone deacetylase inhibitor (HDACI) trichostatin A (TSA). Conclusions: The timing for long-term HORCs use ex vivo is dependent on culture conditions. Long-term HORCs can be used for up to 2 weeks in order to prevent detectable RGC loss. Both VEGF and PDGF possess an ability to prolong …
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Proteins Involved in HDACi Induced Decay of ERBB2 Transcripts in Breast Cancer
… the standard clinical prototype hydroxamic acid, trichostatin-A (TSA). These include the many genomic and non-genomic targets of pan-HDACi, the off-target side effects, and the lack of proven HDAC-dependent cancer pathways predictive of tumor responsiveness. Early observations in our laboratory …
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Identification and Characterization of Potential Modulators of TEK/TIE-2 Signaling
… Mouse endothelial cells treated with Trichostatin A, a potent inhibitor of histone deacetylase, led to an increase in the expression of 4933402E13Rik. Taken together, the results of this study shed new insight on the repertoire of genes implicated in Tie-2 signaling. The identification …
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Small Proline Rich Protein-2 Expression and Regulation in the Caco-2 model of Intestinal Epithelial Differentiation along the Crypt-Villus Axis
… was seen with the specific HDAC inhibitor trichostatin A, while SCFAs and the HDAC inhibitor SBHA all induced SPRR2. SCFA responses were inhibited by MAP kinase inhibitors SB203580 and U0126, thus suggesting that the SCFA effect may be mediated by orphan G-protein receptors GPR41 and GPR43. …
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Dual mTOR/HDAC Inhibition: Preclinical Development of a Novel Breast Cancer Therapy
… MLN0128 that targets mTORC1 and mTORC2, and Trichostatin-A (TSA), a potent inhibitor of both class I and class II HDACs, on the viability, downstream signaling, and polysome assembly of human breast cancer cell lines of various receptor subtypes (HER2-/+ and/or ER -/+), as well as on …
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Evaluation of inhibitors of histone deacetylases as potential neurotrophic agents
… iii neurotrophic action of vorinostat. Trichostatin A (TSA), belinostat and additional pan-HDAC inhibitors, shovariable effects. TSA was ineffective, while belinostat attenuated neurotrophic action of NGF. Belinostat though induced hyperacetylation of H3 & H4 but failed to produce …
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Computational and Pharmacological Characterization of HDAC6 Inhibition and Function
… inhibitors that can inhibit HDAC6. These include Trichostatin A and Vorinostat. Recently there has been a drive towards HDAC6 specific inhibitors due to its presence in these diseases. These inhibitors include Nexturastat A and Ricolinostat (ACY-1215). Within this thesis these four inhibitors have …
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