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Showing 1 to 20 of 34 for “"Trichomonas vaginalis"”.
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Analysis of a trichomonas vaginalis cysteine protease
… focus on the role of cysteine proteases in Trichomonas vaginalis because of their role in virulence of other parasitic protozoa. Determining their location and function will provide insight about their role in the pathogenicity of T. vaginalis and their feasibility as a drug target. This …
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Characterization of subtilisin-like serine proteases in trichomonas vaginalis
<p><em>Trichomonas vaginalis</em> is the etiologic agent causing human trichomoniasis, a sexually transmitted infection found worldwide. In this study, subtilisin-like serine proteases (subtilases) were examined for their putative role in cell viability. Published data of other eukaryotic protozoan …
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Expression and analysis of a legumain from trichomonas vaginalis
<p>Trichomonas vaginalis and Tritrichomonas foetus are the etiologic agents of human and bovine trichomoniasis, respectively. As microaerophilic protozoans; both share a wide array of clinical manifestations ranging from vaginitis to abnormal pregnancies. Human trichomoniasis receives minimal …
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The recombinant expression and localization of TvCP2 of trichomonas vaginalis
<p>Trichomonas vagina/is, one of the most common sexually transmitted diseases, has been shown to increase patients' susceptibility to HIV infection and cervical cancer; moreover, resistance to metronidazole is increasing, and new drug targets must be identified in order to combat resistant …
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Nitric Oxide in the Cytotoxicity of Metronidazole Against Trichomonas Vaginalis
… when 50 mM metronidazole was incubated with 109 Trichomonas vaginalis for one hour at 37°C regardless of whether ascorbic acid was added to the system or not. Further, in all three reduction systems, nitrite ions were separately detected using the Griess reagent. In the Lactate dehydrogenase …
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Characterization of TvDMC1 and TvSOD6 expression and function in trichomonas vaginalis
<p>Trichomonas vagina/is is a common sexually transmitted disease, affecting women more often than men. It has only been seen to undergo mitosis, even though published studies have confinned the organism has meiotic proteins. These meiotic proteins are known to function in other organisms with a …
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Trichomonas vaginalis and bacterial co-infections identified in reproductive age women
… Chlamydia trachomatis, Neisseria gonorrhoeae and Trichomonas vaginalis. In the late 1990s the South African health department introduced the STI syndromic management approach into the primary health care setting. This approach aims to treat the common causes of STI syndromes through the use of …
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Investigation of the expression of DMC1, a meiotic gene, in trichomonas vaginalis
<p>T. vaginalis is a protozoan parasite without an observed sexual stage in its life cycle. However, T. vaginalis has genes, such as Dmc1, known to be involved in meiosis in other organisms. In order to look at the expression of these genes in T. vaginalis, RT-PCR was done using purified mRNA. It …
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Inducible immunity to Trichomonas vaginalis in a mouse model of vaginal infection.
Trichomonas vaginalis is a protozoan parasite that causes a common sexually transmitted disease, trichomoniasis. Despite its high prevalance, the pathogenesis and immunogenicity of T. vaginalis are not well understood. Because currently available therapies are not always effective in treatment or …
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The characterization of cysteine protease 4 and superoxide dismutase 6 in Trichomonas vaginalis
Pathogenesis attributable to infection with Trichomonas vaginalis , the causative agent of Trichomoniasis, is largely unknown although cysteine proteases have been implicated. This paper investigated the role of cysteine protease 4 (CP4) in T. vaginalis through characterization and expression of …
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Efforts to elucidate functional and regulatory aspects of gene expression in Trichomonas vaginalis
Trichomonas vaginalis is a microaerophilic protozoan that resides in the human urogenital tract causing trichomoniasis, a sexually transmitted infection worldwide. It is also an organism of interest for studying the early evolution of eukaryotes. Despite its medical and academic importance, the T. …
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Compound discovery and expression of a putative cathepsin D-like protease in Trichomonas vaginalis
<p>Trichomonas vaginalis is a sexually-transmitted parasite that is the causative agent in the disease trichomoniasis. Resistance to the only FDA-approved medication to this disease, metronidazole, has been on the increase giving rise to the need for finding targets for new inhibitors to exploit. …
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Biochemical analysis of a potential drug target in the human protozoal pathogen Trichomonas vaginalis
<p>Trichomonas vaginalis carries out unique mode of carbohydrate decarboxylation by an intracellular compartment, hydrogenosome. It was suggested that enzymes exclusively associated with hydrogenosome were responsible for activating metronidazole. This provoked researchers to target hydrogensosomal …
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Characterization of the DMCI and Rad51 homologues and the process of meiosis in trichomonas vaginalis
<p>Trichomonas vaginal is is the sexually transmitted agent of trichomoniasis. Although the organism is believed to only reproduce via binary fission, genes specific to 5 Meiosis and Homologous Recombination have been identified in its genome. It is unclear whether the organism has the ability to …
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Identification and molecular characterisation of a putative gene for cell detaching factor from Trichomonas vaginalis.
Trichomonas vaginalis (Tv) is the etiologic agent of trichomoniasis, a sexually transmitted disease of significant socio-economic importance. Cell-free filtrate from Tv growth media causes rounding and detachment of adherent monolayers of human epithelial cells in culture. Cell detaching factor …
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Development of organosilane-containing bioorganometallic compounds evaluated as antiparasitic agents against Plasmodium falciparum and Trichomonas vaginalis
… the spread of the diseases such as malaria and trichomonas's. However, in cases where infection has occurred, pharmaceutical treatments are required. A problem seen across the board is the development of resistance to known treatments. An even bigger problem has been the development of …
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The role of TvTrxR in drug resistance and characterization of TvRad51 in homologous recombination in Trichomonas vaginalis
… of TvRad51 in Homologous Recombination in Trichomonas vaginalis Abstract By Melissa Hopper University of the Pacific 2016 In recent years, prevalence of metronidazole-resistant cases of Trichomonas vaginalis has been on the rise. With nearly 10% of strains resistant to metronidazole, new …
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Microarray analysis of Trichomonas vaginalis strains T1 and G3: Identifying genes that may contribute to virulence and metronidazole resistance
<p>Trichomonas vaginalis is a protozoan parasite responsible for causing nearly eight million cases of Trichomoniasis every year in the United States. Trichomoniasis is often an asymptomatic infection, but in some cases it does lead to mild clinical manifestions. Trichomoniasis is easily treated …
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Trashing old notions: the significance of small tRNAs in Trichomonas vaginalis extracellular vesicles and implications for host-parasite communication
… transmitted infection caused by the protozoan Trichomonas vaginalis. Extracellular vesicles (EVs) released by this parasite have been shown to play a role in priming host cells for infection. However, the contribution of EV RNA cargo to the infection process remains unclear, which inspired the …
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