Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Tribbles"”.
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Identification of motifs in the tribbles kinase required for substrate interactions
The gene tribbles encodes an atypical kinase that is evolutionarily conserved with important roles in regulation of cell signaling. In Drosophila melanogaster Tribbles (Trbl) directs the proteasomal degradation of the C/EBP transcription factor Slbo (slow border cells) to regulate cell migration in …
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The Roles of the Drosophila Protein Tribbles in Oogenesis and Insulin Signaling Pathway
… function of the Drosophila melanogaster protein Tribbles (Trbl) during oogenesis and larval development. Trbl is the founding member of an evolutionarily conserved family of kinase proteins that play diverse roles in cell signaling and energy homeostasis. In addition to the central …
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A Genetic Screen for Tribbles Suppressors Identifies the E3 Ubiquitin Ligase Neuralized as a Novel Target
… a genetic screen to identify novel targets of Tribbles. Drosophila Tribbles is the founding member of a family of pseudokinases conserved between metazoans. Tribbles family proteins have roles in the cell cycle, insulin signaling, tissue growth and early development, and have been associated …
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An investigation of the role of TRIB2 in steady state and stressed haematopoiesis
TRIB2 is a member of the mammalian Tribbles family of serine/threonine pseudokinases (TRIB1-3). Here, we studied murine haematopoiesis after Trib2 ablation under steady state and proliferative stress conditions, including genotoxic and oncogenic stress. At the steady state, we found that TRIB2 loss …
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Élucidation du rôle de trib 1 dans les cas de glioblastome multiforme
… primaires, une élévation des transcrits de tribbles-1 (trib 1) a été observée. Les protéines Tribbles sont des régulateurs clés de multiples voies de signalisation et leur dérégulation est liée à la perte de l'homéostasie cellulaire et à la carcinogenèse. Une biopuce tissulaire …
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UNDERSTADING THE ROLE OF PSEUDOKINASE TRB3 IN CANCER PROGRESSION AND CHEMORESISTANCE DURING METABOLIC STRESS
Mammalian homolog Tribbles (Trbs) is a newly characterized protein family that includes three different isoforms: Trb1, Trb2, and Trb3. Tribbles are serine/threonine kinases lacking catalytic activity, thus their classification as pseudokinases. Despite their catalytic inactivity, Tribbles can …
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Role of TRB3 in Glucose Enhancing Effect on LPS-induced NO Production
TRB3 (Tribbles homolog 3)는 pseudokinase로 알려져 있으며, 세포 내 에너지 대사에 관여할 뿐만 아니라 염증반응 그리고 세포 사멸을 통한 pathological 과정에 관여한다. TRB3의 발현은 영양 상태에 따라 조절된다. 주로 저포도당 (fasting) 상태에서 증가하는 TRB3는 pro-inflammatory cytokine 을 조절하는 NF-κB의 활성화를 저해하는 것으로 알려져 있다. 선행연구에서 포도당농도 변화 따른 LPS에 의해 유도되는 NO생성 변화를 관찰한 결과, TRB3 및 …
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The role of organelle crosstalk in a Drosophila model of Parkinson’s disease
… dPerk. Using this approach, I identified tribbles (trbl) and Heat shock protein 22 (Hsp22) as two novel Drosophila ATF4 (dAtf4) regulated transcripts. Furthermore, I established that dPerk expression leads to translational repression of several mitochondrial proteins. The mitochondria-ER …
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TRIB3 as an integrator of metabolic stresses: Role in lung cancer progression
The pseudokinase Tribbles pseudokinase 3 (TRIB3) is known as a regulator in cellular responses to a variety of stresses such as glucose insufficiency and (ER) stress. Recent studies reported an increased expression of TRIB3 in cancers and its correlation with the poor prognosis in cancer patients. …