Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 98 for “"Trial design"”.
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Bayesian Adaptive Clinical Trial Design
… chemotherapeutic agents, making the conventional trial design paradigm inefficient and dysfunctional. Specifically, the focus of dose-finding trials has shifted from finding the maximum tolerated dose (MTD) to the optimal biological dose (OBD), defined as the dose that optimizes the risk–benefit …
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Challenges facing clinical trial design in oncology
Background: Clinical trials are designed to help patients to live better and/or longer. Each component considered in the design of the trial has the potential to shape and impact the ultimate result. Interpretation of a trial as positive or negative hinges on the endpoint of interest and the trial …
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Deep learning methods for clinical trial design, execution, and analysis
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-10-19 without embargo terms
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Separating Component Signals of Episodic Simulation Using a Catch Trial Design
… uses functional MRI and employs a catch trial design to test the hypothesis that by separating orientation and simulation related activity, novel differences might be found between the acts of remembering and imagining events. We find that regions typically shown to activate above …
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Innovative Alzheimer's disease clinical trial design in the coming age of biomarkers
… drugs in recent years, the length of AD clinical trials has tripled and the enrollment has gone up drastically. These investigational disease-modifying drugs address new targets including the amyloid beta and tau protein aggregation pathways in the brain. They have opened up a whole research field …
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Novel combination strategies with Aurora Kinase Inhibitors: using pre-clinical data to guide clinical trial design
… (AKI) in pre-clinical models and then to design a clinical trial to assess these in patients with bladder cancer. Particular interest was stimulated by the correlation between over-expression of aurora kinases (AKs) with aggressive clinical behaviour in many cancers and the network of …
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Age-Dependent Variability in Immune Host Responses to SARS-CoV-2: Implications for Inclusive Clinical Trial Design
… of older adults in COVID-19 vaccine clinical trials to assess whether key age-associated immune differences are being adequately captured in clinical research. In Chapter 1, we examined the effects of IFNβ pre-treatment on SARS-CoV-2 infection dynamics in lung epithelial cell models. We …
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Topics in Bayesian adaptive clinical trial design using dynamic linear models and missing data imputation in logistic regression.
Conventional Phase II clinical trial designs usually employ a logistic regression model to analyze the efficacy of a new drug and, therefore, assumes monotone dose-response relationship. Also, the logistic regression model requires the response to be categorical and, thus, it is not applicable for …
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An Innovative Phase I Trial Design Allowing For The Identification of Multiple Potential Maximum to lerated Doses With Combination Therapy of Targeted Agents
… used both in medical practice and clinical trials. Korn and Simon listed three reasons for the utility of combinations: 1) biochemical synergism, 2) differential susceptibility of tumor cells to different agents, and 3) higher achievable dose intensity by exploiting non-overlapping …
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Improving Outcomes for People Living With Unrelieved Neuropathic Cancer Pain - Understanding the Epidemiology, Patient Experience and Optimal Clinical Trial Design: The INCEPT Mixed Methods Project
… cancer pain, and a pilot randomised controlled trial of lidocaine infusion with an embedded semi-structured interview sub-study of trial feasibility and acceptability. Mid-study and end-study meta-inferences integrated the results. 𝗙𝗶𝗻𝗱𝗶𝗻𝗴𝘀 Distress from unrelieved neuropathic cancer pain is …
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Changes in the characteristics of approved New Drug Applications for antihypertensives
… for my effort to investigate how clinical trial design has evolved for antihypertensive drug submissions reviewed and approved by the Food and Drug Administration between 1988 and 2001. To do this, I have constructed and undertaken a preliminary analysis of a number of quantitative …
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Evaluating Digital Health Technologies to Advance Parkinson's Disease Care
… dysfunction. 2. The iterative, user-centred design and formative evaluation of NMS Assist, a smartphone-based app to enable regular assessment of NMS as well as provide education for patients. The app was found to be highly usable, and key areas of amendment were identified. 3. A clinical …
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A home-based physical activity programme in combination with massage therapy to improve motor and cognitive development in HIV positive children on antiretroviral therapy: A randomised controlled trial
… evaluate the effectiveness of an individually designed home-based physical activity programme in combination with massage therapy, on motor and cognitive development in children infected with HIV. This study used a randomized controlled trial design. One hundred and twenty-eight infants and …
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Data-driven Analysis of Clinical Trials
… combines two studies in the field of clinical trials. The first evaluates the amyotrophic lateral sclerosis (ALS) drug AMX0035 using Bayesian decision analysis (BDA), balancing FDA safety standards with patient needs. This method provides a quantitative way to consider both the patient’s …
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Retention strategies for clinical trials; exploring the costs, planning and communication processes
… Participant retention in randomised controlled trials is an ongoing challenge for trial teams. If trials lose large numbers of participants, the trials’ ability to answer the research question is jeopardised. Trial teams often use retention strategies, activities aimed at facilitating ongoing …
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Essays on innovation in health care markets
… incentives on reported drug efficacy in clinical trials. I leverage the insight that the exact same sets of drugs are often compared in different randomized control trials conducted by parties with different financial interests. I estimate that a drug appears 0.15 standard deviations more …
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Modified 3+3 Design for MTD Re-estimation
The 3+3 clinical trial design is one of the most popular dose-finding designs used in phase I oncology trials to identify the maximum tolerated dose (MTD) for new treatment regimens. While this design is widely used due to its simplicity , it has some notable limitations, including a maximum of six …
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Effects of Promoting Health Among Teens: A Brief General Health Program Intervention For African American Adolescents From A Multi-Site Trial
… the eastern United States. A randomized control trial design was used to determine differences in general health knowledge and health behaviors among participants in PHAT and a sexual health control group. Data were collected at baseline, three-months, six-months, and twelve months. Hierarchical …
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Process and outcome evaluation of a school-based HIV/AIDS prevention intervention in Cape Town high schools
… of a theory-based HIV prevention intervention designed for grade 8 high school students. The intervention was delivered by teachers over a 6-month period. The objectives of the research were (i) to conduct a systematic review of evaluation studies of international and South African school-based …
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Process evaluation of a school-based HIV/AIDS intervention in South Africa
… of a theory-based HIV prevention intervention designed for grade 8 high school students. The intervention was delivered by teachers over a 6-month period. The objectives of the research were (i) to conduct a systematic review of evaluation studies of international and South African school-based …
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