Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 103 for “"Tregs"”.
-
Novel markers for human T regulatory cells in healthy donors and cancer patients
CD4+CD25+FoxP3+ T regulatory cells (Tregs) are essential for maintaining self-tolerance and preventing autoimmune diseases. However, FoxP3+ Tregs contribute to the progression of cancer and their levels expand in cancer patients compared to healthy donors. Tregs suppress tumour-specific immune …
-
CHARACTERIZATION OF THE EPIGENOMIC PROFILE SHAPING HUMAN FOXP3+ REGULATORY T CELL IDENTITY IN THE TUMOR MICROENVIRONMENT
… In this context, CD4+ FOXP3+ regulatory T cells (Tregs) have emerged as a major immunosuppressive population sustaining cancer progression. In physiological conditions they mediate immune tolerance and maintain balance in immune responses, controlling their intensity and timing. Moreover, Tregs …
-
Investigating The Possible Role Of Regulatory T Cells In Suppressing DTwP And Measles-Vaccine Induced Responses In 9 Month-Old Gambian Infants
… responses to vaccines. Regulatory T cells (Tregs) control pro-inflammatory responses and are therefore important in maintaining a fine balance of immune responses during infections. Tregs are high and functional in neonates, but their precise role in controlling vaccine immunogenicity is not …
-
Porcine circovirus associated disease: Modulation of the host immune response to PCV2 and PRRSV by regulatory T cells
… PCV2 or both to induce regulatory T cells (Tregs) was evaluated in vitro. DCs infected with PCV2 significantly increased CD4+CD25+FoxP3+ Tregs (p<0.05) and DCs co-infected with PRRSV and PCV2 induced significantly higher numbers of Tregs than with PCV2 alone (p<0.05). This Treg induction was …
-
LINKING HISTONE LACTYLATION TO THE EPIGENETIC REPROGRAMMING OF CD4+ T REGULATORY LYMPHOCYTES IN THE TUMOR ECOSYSTEM
Tumor infiltrating regulatory T cells (TI-Tregs) exhibit a complex interplay with various cell types, including tumor cells, immune cells, and stromal cells thereby promoting tumor growth and invasion. TI-Treg are transcriptionally and epigenetically adapted to the hostile tumor microenvironment …
-
Defining the biological role of FOXP3 in human CD4+ T cells
The involvement of regulatory T cells (Tregs) in immune homeostasis is now recognized as one of the fundamental mechanisms of immune tolerance. While several different types of Tregs cooperate to establish and maintain immune homeostasis, much current research is focused on defining the …
-
Role of Splenic B Cells and Gamma Delta T Cells in the Induction of Peripheral Tolerance Elicited Through the Anterior Chamber of the Eye
… by antigen-specific regulatory T cells (Tregs). ACAID regulates harmful immune responses that can lead to irreparable injury to innocent bystander cells that are incapable of regeneration. ACAID is a product of complex cellular interactions that involve F4/80+ ocular antigen presenting …
-
Peripheral Generation of Regulatory T Cells in Health and Disease
CD4+CD25+FOXP3+ regulatory T cells (Tregs) form an important arm of the immune system responsible for suppressing untoward immune responses. They play a role in autoimmunity, allergy, asthma, transplantation, tumors and infectious diseases. Tregs are increased in the peripheral blood of chronic …
-
Characterising the gene regulatory landscape of CD4+ T cells
… T cells, and particularly in regulatory T cells (Tregs). CD4+ T cells are the orchestrators of the adaptive immune response and their dysfunction has been associated with immune-mediated disorders through uncontrolled activation and resistance to downregulation, which is usually mediated by Tregs. …
-
Non-conventional Regulation of Treg Development and Function
… of new therapeutics is an utmost priority. Tregs are vital in maintaining immunological tolerance and preventing inappropriate inflammatory responses. Despite having no obvious functional defects, Tregs are unable to regulate inflammation in human IBD patients. The role of the gut homing …
-
The role of regulatory T cells in stroke recovery
… subpopulation termed regulatory T cells (Tregs) appears to correlate with improved disease outcome. However, the impact of stroke on Tregs, and the contribution of these cells to stroke recovery remains under debate. Likewise, attempts at developing Treg-targeted immunotherapies have been …
-
Forkhead Transcription Factors Foxp1 and Foxp4 Regulate T Cell Development and Function
… of Foxp1/4 in Foxp3+ regulatory T cells (Tregs). Tregs are critical for prevention of autoimmunity and controlling immune responses during infection. While conditional deletion of either Foxp1 or Foxp4 in T cells has little effect on Tregs, combined deletion results in abnormal Treg …
-
Phenotypic and Functional Analysis of Regulatory T Cells during Heligmosomoides polygyrus infection
… respectively. However, the differences in the Tregs generated during helminth infection compared to steady state natural T regs have yet to be fully elucidated. Classically, in mice, Tregs are defined as CD4+CD25+ T cells. We have demonstrated that, unlike in BALB/c mice, in C57BL/6 animals, …
-
Low-dose IL-2 for T-regulatory cell expansion after alemtuzumab therapy in relapsing-remitting multiple sclerosis
T-regulatory cells (Tregs) are vital for the prevention of autoimmunity, and they require interleukin-2 to function optimally. Their expression of the high-affinity IL-2 receptor, containing the CD25 subunit, renders them 10-fold more sensitive to IL-2 than effector cells (Teffs). Low-dose IL-2 …
-
The control of Foxp3+ regulatory T cell by interleukin-4 receptor alpha-mediated signaling
… important role in determining the fate of Foxp3+ Tregs. In vivo, IL-4-mediated signaling via Interleukin-4 receptor alpha (IL4Rα) was convincingly shown to mediate Treg transdifferentiation into ex-Foxp3 Th2 or Th17 cells, suggesting a negative regulation of Foxp3+ Tregs by IL-4Rα-mediated …
-
Unveiling Immune Checkpoint Therapy Resistance Mechanisms In The Tumor Microenvironment Using High-Dimensional Analyses
… suppressive myeloid cells, regulatory T cells (Tregs), and cancer-associated fibroblasts (CAFs), plays a pivotal role in ICT responses. Leveraging single-cell technologies, this study explores the role and function of immune subsets in the TME that induce therapy resistance.</p> <p>Using …
-
Characterizing T Cell Features of Atypical Lymphocytes for the Optimization of Adoptive Immunotherapies
… Two such populations are regulatory T cells (Tregs) and CAR (chimeric antigen receptor-modified) T cells. The functional role of Tregs in the immune system is non-canonical, in that they prevent hyper-inflammation and resolve immunopathology by constraining conventional immune cell effector …
-
Factors Influencing Regulatory T Cell Maintenance for the Control of Autoimmunity
Regulatory T cells (Tregs) are a subset of CD4+ T cells with suppressive function and are critical in limiting autoimmunity. Increasing Treg numbers can be beneficial in the treatment of several inflammatory disorders. Here, we investigate the roles played by various factors on the control of Treg …
-
Investigation of CD4+ T cell heterogeneity and function in a genetic mouse model of lung adenocarcinoma
… a variety of mechanisms. Regulatory T cells (Tregs) in particular are an immunosuppressive subpopulation of CD4+ T cells that may play a central role in immune tolerance to tumors. Targeted manipulation of tumor-promoting CD4+ T cells could augment the efficacy of existing immunotherapies, but …
-
Protective Immunity in Atherosclerosis
… by immunosuppressive regulatory T cells (Tregs). Immunizations of hypercholesterolemic mice with oxidized LDL or peptides derived from the protein part of LDL, apoB-100, inhibit the development of atherosclerosis. The protective immunity induced by the apoB-100 peptide vaccine aBp210 is …
Page 1 of 6