Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 51 for “"Treg cells"”.
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Depletion of Treg cells for potentiation of cancer treatment with HPMA copolymer-bound cytostatic drug conjugates"
… Cílem této práce bylo odstranění regulačních T (Treg) buněk z organismu aniž by došlo k ovlivnění dalších imunokompetentních buněk, které hrají významnou roli v eradikaci nádoru. Je známo, že Treg buňky tlumí protinádorové imunitní reakce a podporují růst nádoru. Jejich eliminace by tudíž v …
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The Development and Function of Memory Regulatory T Cells
… occurring CD4+CD25+Foxp3+ regulatory T cells (TReg) are a cell lineage that develops in the thymus and exits to the periphery, where they represent 5-10% of the peripheral CD4+ T cell population. Phenotypically, they are characterized by the expression of the cell surface markers CD25, …
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Role and specificity of regulatory T cells during retroviral infection
… persistent infection of hematopoietic cells. The results obtained suggested that unregulated CD4+ T cell response to FV causes bone marrow pathology and anaemia. Regulatory T (Treg) cells are a subset of CD4+ T cells which have been shown to suppress immune responses and to have …
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The role of the class III phosphoinositide 3-kinase VPS34 in regulatory T cells and activated CD8+ T cells
… we explored whether VPS34 is critical for immune cells by generating conditional knockout mice where exon 21 of Pik3c3 (the VPS34 gene) is deleted specifically in regulatory T (Treg) cells or activated CD8+ T cells, respectively. We found that mice with VPS34-deficient Treg cells died within 6 …
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Pten Signaling in Regulatory T Cells and Inflammatory Disease
Regulatory T (Treg) cells suppress CD4+ T cell responses during homeostasis and inflammation to prevent autoimmunity and other immune disorders. Although the transcriptional and epigenetic programs impacting Treg cell function have been extensively studied, the signaling and metabolic pathways …
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Examining the Role of Regulatory Lymphocytes in a Mouse Model of BCL1 Tumor Dormancy
… is a clinical state where residual tumor cells persist for long periods but do not cause detectable disease. However, tumor regrowth can occur and is accompanied by resistance to treatment and high mortality rates. The mechanisms that mediate tumor dormancy have been studied using the …
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IL-2-Dependent Regulation of Immune Homeostasis and Response to Infection
… through its impact on both regulatory T (Treg) and effector T (Teff) cells. However, the precise role of IL-2 in the homeostatic maintenance and function of Treg cells in the adult peripheral immune system remains unclear. Here, we report that neutralization of IL-2 in mice abrogated all …
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Variations in Antigen Presentation Define Regulatory T Cell formation and Activity in Vivo
… and activity of Foxp3+ regulatory T (Treg) cells can be affected by variations in the amount of a cognate antigen (Ag) that is present, the cell types by which it is expressed and/or presented, and whether Ag recognition occurs in an inflammatory environment. Recognition of a weakly …
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E3 Ubiquitin Ligase Cbl-b deficient T cells resist Treg cell-mediated suppression and enhance anti-tumor immunity
Regulatory T cells are one of the integral components of the adaptive immune system that contribute to the regulation of anti-tumor T cell responses. However, studies have suggested that alterations in T cell signaling networks can result in T cells that are resistant to the suppressive effects of …
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Investigating the role of IL-4Rα mediated signalling on Foxp3⁺ T regulatory cells during cutaneous leishmaniasis
… (IL-4Rα). Forkhead box P3 (Foxp3⁺) Regulatory T (Treg) cells are an unique subset of CD4⁺ T cells that play important immunomodulatory roles maintaining a balance between Type 1 and Type 2 immune responses. During L. major-induced cutaneous leishmaniasis, Treg cells accumulation at the site of …
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Development Of Regulatory T Cells Capable Of Maintaining Immune Homeostasis
The adaptive immune response, comprised of both T cells and B cells, is essential to control infections and eliminate transformed cancer cells. The success of the adaptive immune system relies on the ability to discriminate self from non-self-antigens. The thymus is the site of selection for T …
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Follicular Regulatory T cell migration and differentiation
… response requires Follicular regulatory T (Tfr) cells, a subset of Foxp3+ Treg cells located within germinal centres. Tfr cells were first characterised in detail in 2011 and because of this relatively little is known about the exact role of Tfr cells within the GC, and the mechanism/s through …
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Control of inflammation, helper T cell responses and regulatory T cell function by Bcl6
Regulatory T (Treg) cells represent an important layer of immune-regulation indispensible for curtailing exuberant inflammatory responses and maintaining self-tolerance. Treg cells have translational potential for autoimmunity, inflammation, transplantation and cancer. Therefore, delineating the …
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Role of CD4+CD25+ Regulatory T Lymphocytes in Experimental Toxoplasmosis
… with <i>Toxoplasma gondii</i>. T regulatory (Treg) cells have been shown to play an important role in our immune system in controlling the activity of other T lymphocytes. These cells are differentiated from other T lymphocyte populations based on the co-expression of CD4 and CD25 and …
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On Thymic Regulatory T-Cell Ontogeny
<p>Regulatory T (Treg) cells play a pivotal role in maintaining immune homeostasis and preventing autoimmunity. Like most T cells, Treg development occurs primarily in the thymus, where T-cell precursors undergo a series of developmental stages, including double-negative (DN), double-positive (DP), …
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The control of Foxp3+ regulatory T cell by interleukin-4 receptor alpha-mediated signaling
T regulatory (Treg) cells play a pivotal role in the maintenance of self-tolerance and immune homeostasis. Forkhead box P3 (Foxp3)+ Treg function is controlled by environmental cues of which cytokine-mediated signaling is a dominant component. Recently, Interleukin (IL)-4 has been shown to play an …
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Control of chromatin accessibility during CD4+ T cell development and activation
T cells coordinate immune functions by differentiating into highly specialised cellular lineages that either promote or suppress immune reactions. Whereas effector T (Teff) cells drive immune activation and promote clearance of infections and cancer, regulatory T (Treg) cells suppress their …
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Regulation of Autoimmune Germinal Center Reaction By Tfh Cells and Application of Tfr-Like Cells For The Treatment of Autoimmune B Cell Responses
… and functional aberrations of T regulatory T (Treg) cells are common in patients with autoimmune diseases. Although different types of immunosuppressive agents have been used clinically to treat antibody-mediated autoimmune diseases, they generally have side effects due to the lack of …
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Helicobacter pylori Type 4 Secretion System Modulates Host T Cell Responses
… cancer. During H. pylori infection CD4+ T cells in the gastric lamina propria are hyporesponsive and polarized to Th1/Th17 cell responses controlled by Treg cells. Gastric epithelial cells (GECs) are the primary target for H. pylori infection and may act as antigen-presenting cells (APCs) …
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Mechanisms of CD4+ Regulatory T Cell Heterogeneity in Health and Disease
Regulatory T (Treg) cells are central to the maintenance of immune homeostasis and their dysfunction underlies the pathology of numerous diseases. Treg cell populations are phenotypically heterogeneous, comprising functionally quiescent resting Treg (rTreg) cells, which upon antigen stimulation, …
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