Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 147 for “"Treg"”.
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Non-conventional Regulation of Treg Development and Function
… of new therapeutics is an utmost priority. Tregs are vital in maintaining immunological tolerance and preventing inappropriate inflammatory responses. Despite having no obvious functional defects, Tregs are unable to regulate inflammation in human IBD patients. The role of the gut homing …
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A HIF-INDEPENDENT PROGRAM SUSTAINS TUMOR TREG FUNCTION IN OXYGEN-DEPRIVED ENVIRONMENTS
… (TME) is both hypoxic and enriched with Treg. Their function in hypoxia has been poorly characterized. Definition of Treg responses to hypoxia would enable their selective targeting in cancer therapy, bypassing potential systemic adverse effects. We showed TME hypoxia and Treg …
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Depletion of Treg cells for potentiation of cancer treatment with HPMA copolymer-bound cytostatic drug conjugates"
… Cílem této práce bylo odstranění regulačních T (Treg) buněk z organismu aniž by došlo k ovlivnění dalších imunokompetentních buněk, které hrají významnou roli v eradikaci nádoru. Je známo, že Treg buňky tlumí protinádorové imunitní reakce a podporují růst nádoru. Jejich eliminace by tudíž v …
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E3 Ubiquitin Ligase Cbl-b deficient T cells resist Treg cell-mediated suppression and enhance anti-tumor immunity
… that are resistant to the suppressive effects of Treg cells. Here, we specifically investigated the role of E3 ubiquitin ligase Cbl-b in establishing T cell resistance to Treg cell-mediated suppression. First, we found that the absence of Cbl-b, a negative regulator of multiple TCR signaling …
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The Development and Function of Memory Regulatory T Cells
… occurring CD4+CD25+Foxp3+ regulatory T cells (TReg) are a cell lineage that develops in the thymus and exits to the periphery, where they represent 5-10% of the peripheral CD4+ T cell population. Phenotypically, they are characterized by the expression of the cell surface markers CD25, as known …
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Mechanisms of CD4+ Regulatory T Cell Heterogeneity in Health and Disease
Regulatory T (Treg) cells are central to the maintenance of immune homeostasis and their dysfunction underlies the pathology of numerous diseases. Treg cell populations are phenotypically heterogeneous, comprising functionally quiescent resting Treg (rTreg) cells, which upon antigen stimulation, …
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Development Of Regulatory T Cells Capable Of Maintaining Immune Homeostasis
… of suppressor cells termed regulatory T cells (Treg cells) co-evolved in order to keep these self-reactive escapees in check. Treg cells that develop in the thymus as part of central tolerance induction are a critical population of T cells that are required to maintain immune homeostasis and …
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Pten Signaling in Regulatory T Cells and Inflammatory Disease
Regulatory T (Treg) cells suppress CD4+ T cell responses during homeostasis and inflammation to prevent autoimmunity and other immune disorders. Although the transcriptional and epigenetic programs impacting Treg cell function have been extensively studied, the signaling and metabolic pathways …
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Activation of T regulatory cells in Type II Immune Responses
… T cells, CD4+CD25+CD127lo T regulatory cells (Treg), and B cells of patients on dialysis (ESKD) and renal graft recipients of varying lengths, and compared them to healthy volunteers. Demonstrating the heterogeneity of Treg, Miyara et al. (2009) have identified five populations (Pop) within …
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Role and specificity of regulatory T cells during retroviral infection
… bone marrow pathology and anaemia. Regulatory T (Treg) cells are a subset of CD4+ T cells which have been shown to suppress immune responses and to have protective roles in other models of bone marrow pathology. Therefore, the role of Treg cells in the model of FV-induced immune pathology was …
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Factors Influencing Regulatory T Cell Maintenance for the Control of Autoimmunity
Regulatory T cells (Tregs) are a subset of CD4+ T cells with suppressive function and are critical in limiting autoimmunity. Increasing Treg numbers can be beneficial in the treatment of several inflammatory disorders. Here, we investigate the roles played by various factors on the control of Treg …
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The role of the class III phosphoinositide 3-kinase VPS34 in regulatory T cells and activated CD8+ T cells
… gene) is deleted specifically in regulatory T (Treg) cells or activated CD8+ T cells, respectively. We found that mice with VPS34-deficient Treg cells died within 6 weeks of birth from an autoimmune lymphoproliferative disease, similar to mice lacking Treg cells. However, VPS34- deficient Treg …
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T-cell Receptor CDR3 Sequence but Not Recognition Characteristics Distinguish Autoreactive Effector and Foxp3+ Regulatory T-cells
<p>Regulatory T-cells (Treg) play an important role in maintaining immune tolerance to self-antigens and in suppressing excessive immune responses in the host. The source, specificity, and plasticity of the forkhead box transcription factor 3 (Foxp3<sup>+</sup>) Treg and conventional T (Tconv) cell …
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IL-2-Dependent Regulation of Immune Homeostasis and Response to Infection
… through its impact on both regulatory T (Treg) and effector T (Teff) cells. However, the precise role of IL-2 in the homeostatic maintenance and function of Treg cells in the adult peripheral immune system remains unclear. Here, we report that neutralization of IL-2 in mice abrogated all …
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Variations in Antigen Presentation Define Regulatory T Cell formation and Activity in Vivo
… and activity of Foxp3+ regulatory T (Treg) cells can be affected by variations in the amount of a cognate antigen (Ag) that is present, the cell types by which it is expressed and/or presented, and whether Ag recognition occurs in an inflammatory environment. Recognition of a weakly …
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Follicular Regulatory T cell migration and differentiation
… regulatory T (Tfr) cells, a subset of Foxp3+ Treg cells located within germinal centres. Tfr cells were first characterised in detail in 2011 and because of this relatively little is known about the exact role of Tfr cells within the GC, and the mechanism/s through which they exert their …
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Control of chromatin accessibility during CD4+ T cell development and activation
… of infections and cancer, regulatory T (Treg) cells suppress their function to prevent excessive immune reactions that would otherwise result in autoimmune and allergic disease. During cell fate decisions, access to lineage-specific regulatory elements in the genome, which is tightly …
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Mechanistic Elucidation and Therapeutic Improvement of Anti-CTLA-4 Therapies
… axis or Fc effector-mediated regulatory T cell (Treg) depletion governing efficacy. Here we report the engineering of a non-antagonistic CTLA-4 binding domain (b1s1e2) that depletes intratumoral Tregs as an Fc fusion. Comparison of b1s1e2-Fc to 9d9, an antagonistic anti-CTLA-4 antibody, allowed …
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Mechanisms Mediating Asthma Tolerance Induced By Regulatory Dendritic Cells Through CD4+CD25+Foxp3+ T Regulatory Cells
… role of CD4+CD25+Foxp3+ regulatory T cells (Treg) in the induction of tolerance by DC10 in three levels. We first used the siRNA approach to silence IL-10 gene expression in murine DC10 and we generated DC10 from CD80/86 or H-2Iab gene-KO mice. When used to treat asthmatic mice, the …
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Examining the Role of Regulatory Lymphocytes in a Mouse Model of BCL1 Tumor Dormancy
… depending on the disease stage. Regulatory T (Treg) cells play a key role in maintaining systemic immune tolerance and have been described to promote cancer progression. The objective of this study was to determine the role of Treg cells in preventing BCL1 tumor dormancy by suppressing the …
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