Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Treatment of colon cancer."”.
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Zirconocene-Mediated Carbonylative Coupling of Grignard Reagents and Cancer Prevention via Compounds that Modulate 15-PGDH
This manuscript consists of two chapters. The first chapter describes the carbonylative coupling of Grignard reagents using organozirconocene intermediates. Organozirconocenes are versatile synthetic intermediates that can undergo carbonylation to yield acyl anion equivalents. Zirconocene …
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Regulation of cytotoxic drug-induced apoptosis by death receptor 5 in human colon cancer cells
… a cytotoxic drug that is widely used for the treatment of colon cancer. However, 5-FU-resistance is still a common issue which needs to be overcome. Understanding the molecular pathway of 5-FU-induced apoptosis will help designing more effective cancer treatments. Chemotherapeutic drugs such …
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Design, Synthesis, and Evaluation of Novel Positron Emission Tomography Radiotracers
… extracranial tumor in patients under 1 year of age and it constitutes about 8-10% of all childhood cancer. It originates from neural crest cells that normally differentiate to form the sympathetic ganglia, adrenal medulla and other paraspinal sites where sympathetic nervous system tissue is …
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Anti-CD47 targeting therapy for the treatment of colon and pancreas cancers.
CD47 is a "don't eat me" signal over expressed on cancer cells inhibiting their engulfment by phagocytes. A novel monoclonal antibody, Hu5F9-G4, blocking CD47's interaction with its ligand SIRPα allowed for phagocytosis of colorectal and pancreas tumors by macrophages. In some models, treatment of …
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Surguvant inflammation and metabolism in colorectal surgery
… in the perioperative period may predispose to colon cancer recurrence. This thesis examined the ability to harness perioperative body composition, cell free DNA (cfDNA) and metabolomic data and apply these as prognostic markers and potential therapeutic targets in the treatment of colon cancer. …