Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 236 for “"Treatment Response"”.
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Treatment Response Prediction in Acute Myeloid Leukemia Patients
Predicting acute myeloid leukemia (AML) patient treatment response has the potential to impact clinical decisions. A prediction given at the time of diagnosis for treatment response can assist physicians in making effective treatment decisions and improving patient prognosis. This project aimed to …
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Cardiovascular Risk Genes in Prevention and Treatment Response
… disease (CVD) could be used in prevention and treatment of CVD. SUBJECTS: Subjects from the population-based Malmö-Diet-and-Cancer-(MDC)-Study (n=30447) and hypertensives from the Nordic-Diltiazem-(NORDIL)-Study (n=10881). METHODS AND RESULTS: A nine-SNP-lipid-genetic-risk-score was related to …
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Determinants of systemic treatment response in atopic dermatitis
… targeted therapies, predictors of individual treatment response remain poorly defined. This thesis investigates systemic therapies for AD by integrating real-world registry data, clinical trials, and molecular skin analyses. First, data from the TREATgermany registry were used to compare …
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Improving Quantitative Treatment Response Monitoring With Deformable Image Registration
… potential to provide an in vivo assessment of response to radiotherapy (RT). However, comparing tissue tracer uptake in longitudinal studies is often confounded by variations in patient setup and potential treatment induced gross anatomic changes. These variations make true response monitoring …
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Exploring miR-142-3p in cervical cancer: Implications for treatment response
… cancer remains a major global health burden, and treatment resistance, particularly to cisplatin, significantly limits therapeutic success. MicroRNAs (miRNAs) and extracellular vesicles (EVs) have emerged as important regulators of tumor behavior, with the potential to influence both treatment …
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Long-term treatment response, predictors and biochemical markers in Alzheimer’s disease.
… rivastigmine, galantamine) were introduced as treatments for AD. Multiple short-term randomised clinical trials of ChEI treatment show beneficial effects on cognition, global functioning and activities of daily living in AD. Whether the effects of long-term ChEI treatment in a routine clinical …
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Renal Cryoablation: Investigation of Periprocedural Visualization to ols and Treatment Response Quantification
… these visual comparisons by quantifying tissue response to cryoablation and providing visualization of the response during the procedure.</p> <p>Based on retrospective analysis of MR-guided cryoablation patient data, registration and segmentation algorithms were investigated and implemented for …
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Integrative Bioinformatics Approaches to Elucidating Prostate Cancer Cell Heterogeneity, Plasticity, and Treatment Response
<p>Prostate cancer (PCa) is the most common non-cutaneous tumor in American men, and the second leading cause of cancer-related deaths. PCa-related deaths can be attributed to heterogeneous tumors containing metastatic and therapy-resistant cancer cells. Cancer stem cells (CSC) are an important …
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Tracking Treatment Response and Resistance to Parp Inhibition (Talazoparib) In Hereditary Pancreatic Cancer.
… the first FDA-approved PARP inhibitor for the treatment of <em>BRCA</em>-mutant ovarian cancer. In the phase III POLO (Pancreas cancer OLaparib Ongoing) trial presented at the American Society for Clinical Oncology (ASCO) conference in 2019, maintenance therapy with Olaparib significantly …
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DNA repair deficiencies as a biomarker for treatment response in acute myeloid leukaemia
… patients will or will not respond to Cytarabine treatment. An assay, developed in 2014, used microarray data to determine which breast cancer patients had a DDRD and therefore would be more responsive to DNA damaging agents. This project hass assessed the potential of using the DDRD assay for AML …
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Transcriptomic signatures of recurrent tuberculosis disease and treatment response in HIV-infected individuals
… TB. This would also allow the provision of TB treatment in persons with subclinical TB. Diagnosis of TB in HIV-infected persons is markedly undermined by the paucibacillary nature of HIV-associated disease. A non-sputum based diagnostic test that is highly sensitive and specific, such as a …
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Personalized Treatment Response Prediction under Dynamic and Time-Varying Treatment Strategies for Sepsis Patients
… can be caused by both excessive and insufficient treatment. There have been many clinical trials done in the past to investigate the optimal regime for treating sepsis, however these studies have resulted in inconclusive results and often take a long time to conduct. Thus, personalized treatment …
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The effect of executive function deficits on treatment response in children with Oppositional Defiant Disorder
… solutions (CPS) have been shown to be effective treatments for ODD. Previous studies have not yet investigated the role that executive functioning (EF) deficits play in treatment response for ODD symptomology. Since EF deficits often co-occur with ODD, it is important to consider whether those …
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Host-Based Mechanisms of Ribavirin Resistance: Implications In Treatment Response of Hepatatis C Virus Infection
… (RBV), a nucleoside analog. While RBV improves treatment outcome, and will likely be an important component of therapy with next-generation viral inhibitors, RBV’s mechanism is controversial. Most of RBV’s proposed mechanisms require RBV import into cells. Therefore, we examined whether …
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Characteristics of Exposure Sessions as Predictors of Differential Treatment Response in a Sample of Anxious Youth
Guidelines for conducting effective exposure treatment with anxious youth emphasize content (e.g., preparation for and processing of the exposure) and process (e.g., collaboration and youth involvement) variables as important elements of exposure task sessions, but there is a paucity of research …
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Quantitative Magnetic Resonance Imaging For The Early Prediction of Treatment Response In Triple Negative Breast Cancer
… approximately a 40% rate of pathologic complete response (pCR). A biomarker which could predict TNBC response to NAST early during treatment would be useful, as it would allow for non-responders to be triaged to alternative therapies and potentially allow for the treatment of responders to be …
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Methodological Development of A Multi-Parametric Quantitative Imaging Biomarker Framework For Assessing Treatment Response With Mri
… assessing the spatially heterogeneous treatment response to anticancer therapies, particularly as indicators for early response. MR QIBs are derived from the analysis of <em>in vivo </em>imaging data, such as that acquired via dynamic contrast enhanced (DCE), dynamic susceptibility …
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THE STUDY OF CD24 AS A PREDICTIVE INDICATOR IN CISPLATIN TREATMENT RESPONSE OF HEAD AND NECK CANCER
… CD24-high tumors go on to show an unfavorable response to cisplatin treatment. Overall, based on the strength of further clinical analysis, CD24 presents a strong rationale to be utilized as a predictive indicator to stratify head and neck cancer patients for platinum-based therapy. This study …
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