Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Treatment Interruption"”.
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An exploration of how treatment interruption and default affects Tuberculosis (TB) patients in Oshakati district, Oshana region, Namibia
… the lived experience of TB patients whose treatment was interrupted and those who default the TB treatment. Tuberculosis is an infectious disease caused by a Mycobacterium tuberculosis bacterium. The research project explored the treatment interruption and default among the TB patients in …
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A multi-state model of treatment states in an antiretroviral treatment programme cohort in Cape Town
… countries are not retained on antiretroviral treatment (ART) beyond one year. Further, it is difficult to determine whether a patient who is not retained in care has interrupted their treatment, transferred to another treatment facility, or died. Previous studies have been deterministic in …
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Dynamics of the HIV-1 Latent Reservoir
… burden of disease. Currently, the only effective treatment to suppress viral replication and prevent HIV transmission is combination antiretroviral therapy (ART), which prevents HIV from infecting new cells. Despite the efficacy of ART, long lived latently infected cells persist, with an estimated …
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Short-term outcomes of downreferral in provision of paediatric antiretroviral therapy at Red Cross War Memorial Childrens Hospital, Cape Town
… than 8 weeks, therefore probably experiencing treatment interruption. At 12 months post down-referral only 68.2% remained in care at the designated clinics. No factors were associated with retention in care. For those children who remained in care at the PHC clinics, the clinical and …
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Origin and Correlates of Viral Rebound in SIV-Infected Rhesus Macaques Following Discontinuation of ART
… and then necropsied after a 12-day analytical treatment interruption (ATI). Using molecularly barcoded SIVmac239M, we tracked viral clonotypes following ATI in both peripheral blood and tissues at necropsy. Viral rebound appeared to originate by reactivation of a single or a few barcode …
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Role of delay differential equations in modelling low level HIV viral load
… can not be guaranteed, resulting in therapy interruptions. This, coupled with a significant cost reduction by systematically interrupting therapy, means a set of models which can account for both treatment events need to be developed, as numerous models exist for therapy introduction, but …
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The role of the HIV-1 Tat protein in acute stroke: more than just a transactivator of transcription?
… had a higher prevalence of antiretroviral treatment interruption (25.9% vs 0.0%, p= 0.003), lower CD4 nadir (112 vs 177.5 cells/μl, p=0.008) and CD4 count (208.5 vs 322.5 cells/μl, p=0.012) than controls. Median viral loads were elevated in both strokes and controls (4.58 & 4.13 log10 …
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Development And Validation Of Novel Transmitted/founder Shivs For Hiv-1 Persistence And Cure Research
… cART initiation, and viral rebound following treatment interruption, mirroring HIV infection. Reservoir analyses of both peripheral and lymphoid cells revealed systemic virus dissemination and establishment of viral reservoirs that persisted despite cART. The viral dynamics and reservoir …
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Preoperative Chemoradiotherapy of Locally Advanced Rectal Cancer: Preliminary Results of BID Fractionation
… mainly FOLFIRI (n=25), every 3 weeks. Radiation treatment scheme was 1.5 Gy (n=31) or 1.6 Gy (n=4) of radiation twice a day, and 1st course of radiotherapy of 21-24 Gy was combined concurrently with 1st cycle of chemotherapy followed by 10-12 days rest period and 2nd course of radiotherapy of …
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Patterns of HIV care prior to antenatal care, and the impact on later outcomes, among pregnant women living with HIV in Gugulethu, South Africa: A retrospective cohort
… starting ART, (2) ART-experienced without any interruptions, (3) ARTexperienced with interruption. Log-binomial models were used to assess the association between ART history, viral suppression at delivery and engagement in care at 12 weeks postpartum. Results: Among 321 women (median age 32.3 …
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Integration Sites in the Persistence of Latent HIV-1
… for people with HIV-1 and reduced transmission, treatment is often accompanied by long-term side effects or stigma, or impeded by limited access to health care. Furthermore, because viral load quickly rebounds upon treatment interruption, ART is required to be a life-long medication. The major …
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Linkage to treatment following RR-TB diagnosis in the Western Cape
… to link to appropriate drug resistant (DR) TB treatment. The aim of this study was to explore barriers and enablers to expedited linkage to treatment following RR-TB diagnosis in the Western Cape Province, within the context of ongoing decentralisation of DRTB services and the scale-up of Xpert …
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Evaluation of the costs of managing cutaneous adverse drug reactions to first-line TB therapy in South African TB patients
Background: Optimal tuberculosis (TB) treatment remains the backbone of effective TB control programmes. However, TB drugs are often associated with adverse drug reactions (ADR) that affect treatment adherence and cure. Cutaneous adverse drug reactions (CADR) are more commonly associated with Human …
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Modelling hepatotoxicity in HIV/TB co-infected patients: extensions of the Cox Proportional Hazards Model
… who are co-administering Tuberculosis (TB) treatment and the antiretroviral therapy (ART) for the Human Immunodeficiency Viruses (HIV). If severe, hepatotoxicity sometimes necessitates cessation or interruption of treatment. Therefore, understanding, monitoring and managing hepatotoxicity in …
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Assessing the effectiveness of the ART programme in the Western Cape Province of South Africa through triangulation of context-appropriate population level routine monitoring and surveillance systems
… pool of eligible people needing HIV treatment, and efficiently monitoring programme effectiveness to improve patient care and service delivery. Concerns about the feasibility of further treatment expansion were being debated with trials showing benefit, but with ongoing uncertainty as …