Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 3670 for “"Treat"”.
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Development of Therapies to Treat Polycystic Kidney Disease
… to determine possible drug therapies for the treatment of PKD. Previous studies showed that cyst fluid caused a secretory response in cells lining the cysts. We hypothesized that once the cyst have expanded and become so large that they burst or leak, which could also occur due to renal injury …
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Expanding Antigen-specific Tr1 Cells to Treat Autoimmunity
The goal of a therapy against autoimmune diseases would be to blunt immune responses against self antigens, without impairing systemic immunity. Our lab has been developing a nanoparticle-based therapy which consists of disease-relevant peptide-MHC complexes coated on iron-oxide nanoparticles …
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Targeting pro-inflammatory mediators to treat visceral pain
… GI side effects. To develop much needed, novel treatments, further understanding of the pro-inflammatory mediators and mechanisms underpinning visceral nociception in disease states is required. In GI disease, mast cell number is elevated in the gut and activation leads to synthesis and release …
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TARGETING FIBROBLAST-MATRIX INTERACTIONS TO TREAT VOCAL FOLD SCARRING
… mechanistically-selective antifibrotics for the treatment of VF scarring.
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Romidepsin is a Potential Therapeutic to Treat Metastatic Osteosarcoma
… romidepsin is a potential therapeutic to treat a subset of metastatic osteosarcoma patients.
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Novel strategies to prevent and treat experimental pneumococcal disease
With over 90 different serotypes of Streptococcus pneumoniae unevenly distributed around the world, current vaccine formulations vary significantly in their ability to protect against invasive pneumococcal disease (IPD). The adult pneumococcal vaccine is composed of capsular polysaccharide from 23 …
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Targeting LGALS3 to treat steatotic liver disease and hepatocarcinogenesis
… synthesis. The combination of T3/MGL-3196 treatment and gene silencing did not show worse or better outcomes, suggesting a possible involvement of Gal-3 in the T3 pathway.
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Guiding principles in medical law : the ability to treat
… of the law governing the provision of medical treatment extremely important. This thesis argues that there is a logical and coherent structure to this area of the law. This is achieved through the application of key guiding principles to a range of important issues throughout a patient’s life …
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Computational engineering of small molecules to treat infectious diseases
… new methods to improve an anti-fungal for the treatment of Candida albicans. We use molecular docking to predict a binding mode for the lead compound and then account for receptor plasticity by performing molecular dynamics simulations. We use this improved receptor model to design novel …
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Design of swimming fins to treat Patellofemoral Pain Syndrome
This thesis project involves developing a pair of swimming fins to strengthen the Vastus Medialis, or inner quadriceps muscle, to help patients with Patellofemoral Pain Syndrome. Configurations of mock up fins, made from Lexan, were designed based off of a known dry land exercise that consisted of …
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Targeting CDK to Prevent and Treat Retinoblastoma and other Cancers
… inhibitors has been immense, yet the efficacy in treating established tumors is poor in most cases. Considering that tumor cells co-opt the cell cycle to grow, it is unclear why most cell cycle inhibitors, like CDK inhibitors, have failed to pass Phase II clinical trials. Since expansion of …
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Using Parent-Mediated Intervention to Treat Autism Symptoms in Infants
Autism Spectrum Disorder (ASD) is a neuro-developmental disorder characterized by persistent and significant impairments with social communication and a tendency to engage in non-functional restricted and repetitive behaviours which begin in early childhood. Due to an increase in prevalence and …
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Stem Cell and Biological Interventions to treat Allergic Airway Disease
The aim of this work was to investigate immune modulation with a particular focus on airway inflammation and allergic pathogenesis. This was probed in a model of pathogen driven immunomodulation (B. pertussis), and two models of therapeutic intervention namely immunisation (attenuated B. pertussis, …
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Characterising Triflupromazine as a potential agent to treat glioblastoma multiforme
… for up to 50% of all gliomas. For decades, treatment of this tumour has been limited to surgery with concurrent radiation and chemotherapy with temozolomide (TMZ). However, recurrence is inevitable and resistance develops rapidly despite aggressive treatment regimens leading to a high …
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The Angelman Approach : hacking DNA to treat a rare disease
… are increasingly allowing clinicians to treat genetic illnesses by directly manipulating patients' DNA, and a number of scientists are now investigating ways to leverage those discoveries for individuals with Angelman Syndrome. Their work could lead to potent therapies for the disease, …
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The Correspondence of James Treat: June 9, 1836-April 19, 1839
No abstract prepared.
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A patient specific total disc replacement to treat degenerative disc disease
… intervertebral discs (IVD). When conservative treatments fail, surgical replacement with an artificial total disc replacement (TDR) is often required. However, despite decades of refinement, current TDRs are unable to fully replicate the complex mechanical behaviour of the native intervertebral …
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Using agricultural wastes to treat lead-contaminated water in Western Australia
… and resin) make it cost inhibitive for the treatment of large quantities of wastewater (Cutillas-Barreiro et al. 2016, Demirbas 2008). It also takes a long time in some cases to achieve adsorption equilibrium (Czinkota et al. 2002). In recent decades, interest in the use of cost-effective …
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