Global ETD Search
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Showing 1 to 4 of 4 for “"Trb3"”.
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Role of TRB3 in Glucose Enhancing Effect on LPS-induced NO Production
TRB3 (Tribbles homolog 3)는 pseudokinase로 알려져 있으며, 세포 내 에너지 대사에 관여할 뿐만 아니라 염증반응 그리고 세포 사멸을 통한 pathological 과정에 관여한다. TRB3의 발현은 영양 상태에 따라 조절된다. 주로 저포도당 (fasting) 상태에서 증가하는 TRB3는 pro-inflammatory cytokine 을 조절하는 NF-κB의 활성화를 저해하는 것으로 알려져 있다. 선행연구에서 포도당농도 변화 따른 LPS에 의해 유도되는 NO생성 변화를 관찰한 결과, TRB3 및 …
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UNDERSTADING THE ROLE OF PSEUDOKINASE TRB3 IN CANCER PROGRESSION AND CHEMORESISTANCE DURING METABOLIC STRESS
… three different isoforms: Trb1, Trb2, and Trb3. Tribbles are serine/threonine kinases lacking catalytic activity, thus their classification as pseudokinases. Despite their catalytic inactivity, Tribbles can interact with different proteins and regulate different biological functions. The …
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Transcriptional Regulation of human Plasminogen Activator Inhibitor-1 Gene Expression by Insulin-like Growth Factor-1, Insulin and Upstream Stimulatory Factor-2
… in HepG2-Zellen mit dominant-negative PDK1 oder TRB3, dass Akt/PKB hemmt, hatte keinen Einfluss, während dominant-negatives Raf-1 den IGF-1 Effekt auf HIF-1 alpha wiederum vollständig aufhob. Somit aktiviert IGF-1 die humane PAI-1- Genexpression durch die Aktivierung der PI(3)K und ERK1/2. Durch …
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Effects of prepartum dietary energy and lipid supplementation on hepatic transcriptome profiles in dairy cows during the transition period
… GRP94 and HSP40 was lower in OVE than CON but TRB3, HSPA1A, HSPA1B and CREB3L3 had greater (Diet × Time; P < 0.05) expression in OVE. Expression postpartum of the inflammatory genes NFKB1, RELA, CHUK, MYD88, TNF, SAA3, and PTX3 increased (Diet × Time; P < 0.05) in OVE. Genes associated with …