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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Traumatic spinal cord injury"”.
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Elucidating the role of bone morphogenetic protein-4 in regulating secondary injury mechanisms following traumatic spinal cord injury
Traumatic spinal cord injury (SCI) initiates secondary injury cascades that include, but are not limited to, inflammation, ischemia, reactive astrogliosis and apoptosis. These mechanisms contribute to tissue degeneration and limit neural regeneration and repair after injury. To optimize future …
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Circulating Autoantibodies In Human Traumatic Spinal Cord Injury Subjects and Their Relationship to The Development of Neuropathic Pain
… </strong></p> <p>Approximately 17,500 spinal cord injuries (SCI) occur yearly in the U.S. causing considerable morbidity and mortality. Neuropathic pain (NP) ensues in 40-70% of SCI. An autoimmune response resulting from disruption of the blood-spinal cord-barrier may be a contributor …
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Effect of Acute Administration of Angiopoietin-1 In Experimental Traumatic Spinal Cord Injury: Magnetic Resonance Imaging and Neurobehavioral Studies
Spinal cord injury (SCI) is a devastating condition that affects people in the prime of their lives. A myriad of vascular events occur after SCI, each of which contributes to the evolving pathology. The primary trauma causes mechanical damage to blood vessels, resulting in hemorrhage. The …
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Therapeutic Potential of Protein Kinases and Their Downstream Targets Following Traumatic Cervical Spinal Cord Injury
… in the management and characterization of traumatic spinal cord injury (SCI), the current therapeutic options for patients remain limited. The SCI-induced cellular response is mediated through series of protein kinases, which are a group of globular proteins that reversibly phosphorylate …
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Thalidomid und Rolipram führen zu funktionell relevanten Verbesserungen der Motorik nach traumatischen Rückenmarksverletzungen bei der Ratte
Traumatic spinal cord injury (SCI) causes permanent motor, sensory and autonomic deficits. The primary lesion characterised by the initial mechanic tissue damage is following by a cascade of secondary tissue degeneration. The release of potent pro-inflammatory cytokines tumour necrosis factor alpha …
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Pathological and Biomedical Characteristics of Spinal Cord Injury Determined Using Diffusion Tensor Imaging
Traumatic spinal cord injury: SCI) is the most devastating injury that often causes the victim permanent paralysis and undergo a lifetime of therapy and care. It is caused by a mechanical impact that ultimately causes pathophysiological consequences which at this moment in time are an unresolved …
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Novel Use of Dual Anti-Inflammatory Therapy to Overcome Drug Resistance and Improve Functional Recovery Following Spinal Cord Injury
… million Americans are currently living with a traumatic spinal cord injury (SCI). Despite the need for effective therapies, there are currently no proven effective treatments that can improve recovery of function in SCI patients. Many therapeutic compounds have shown promise in preclinical …
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Investigation of the feasibility of using focal vibratory stimulation with robotic aided therapy for spasticity rehabilitation in spinal cord injury
The occurrence of a traumatic spinal cord injury is in hundreds of thousands of people every year. Survivors are left with loss of many bodily functions, loss of sensation below the point of injury and many more painful and uncomfortable repercussions which interfere with activities of daily …
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Engineering hiPSCs to enhance neural progenitor transplantation in degenerative cervical myelopathy
… cell transplantation has been widely explored in traumatic spinal cord injury (SCI) but has yet to be evaluated as a treatment for degenerative cervical myelopathy (DCM), a non-traumatic form of spinal cord injury. Importantly, the extent of astrogliosis and extracellular matrix remodelling that …
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Model-Informed Drug Development of Riluzole for Neuroprotection in Acute Spinal Cord Injury: Integrating Pharmacokinetics, Pharmacodynamics, and Clinical Outcomes for Precision Medicine
Traumatic spinal cord injury (SCI) is a debilitating condition with no FDA-approved pharmacological therapies. Progress in therapeutic development has been hindered by the complexity of SCI pathophysiology, considerable interindividual variability, and a relatively small patient population. …
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Central nervous system organisation following traumatic incomplete spinal cord injury (iSCI) : a longitudinal clinical study
Traumatic spinal cord injury (SCI) triggers pathophysiological consequences and secondary injuries that combine to determine the extent and final outcome of SCI. This study is aimed at examining a set of electrophysiological tests for their potential practicality and accuracy in assessing …
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Regulation of Oligodendrogenesis in a Rat Contusive Spinal Cord Injury
… hamper functional recovery following traumatic spinal cord injury (SCI). Although proliferating glial progenitor cells (GPCs) are present in the lesioned spinal cord, spontaneous remyelination is extremely limited. The failure of remyelination after SCI may be due to inadequate …
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Étude d’efficacité des techniques de retrait d’équipements sportifs chez des joueurs de football lors de traumatismes vertébraux suspectés en contexte préhospitalier
… management of football players with suspected spinal injuries, support the removal of the helmet and shoulder pad combination by performing spinal motion restriction (SMR) before any mobilizations and transfers. However, current removal techniques are poorly documented and their ability to …