Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 145 for “"Transposable"”.
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Transposable Elements in Neural Progenitor Cells
… gene expression and is therefore indispensable. Transposable elements comprise about 50% of the genome and co-exist as symbionts regulated by epigenetic mechanisms - a highly defined machinery that controls gene expression and is mandatory for a proper development and maintenance of an organism. …
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Understanding Host Tolerance to Transposable Elements
Transposable elements (TE) are mobile genetic parasites, whose unregulated activity in germline causes DNA damage, and results in sterility. Host genomes can avoid these fitness costs of TEs either by regulating TE proliferation, or by altering gametogenesis to tolerate TE-induced DNA damage. …
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Mosquito Transposable Elements and piwi Genes
… with disease-resistant transgenic mosquitoes. Transposable elements (TEs) are an important component in this new strategy due to their ability to integrate exogenous DNA into chromosomes. They could potentially be useful tools in assisting the spread of disease-resistant genes in mosquito …
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Observing and quantifying transposable element activity inside living cells
Evolution is driven by the activity of transposable elements, ‘jumping genes’ that are ubiquitous to all life forms. To study their dynamics in higher resolution, transposable elements were genetically engineered for tunable expression inside living cells, then tracked in real time using …
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Transposable elements and the regulatory logic of hematopoietic differentiation
… In this thesis, I describe several studies on transposable elements (TEs) as natural and engineered sources of regulatory innovation that contribute to, and aid in the investigation of, dynamic cellular processes. Toward this end, I built comprehensive genome-wide enhancer-gene maps spanning …
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Measurements and analyses of transposable element activity inside living cells
Transposable elements (TEs) are DNA elements that move into different places in the DNA. Through their activity, they can restructure genomes and play crucial roles in evolution, development, and genetic disease. However, characterization of their detailed in vivo dynamics has been limited by a …
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Mechanisms governing transposable element expression in the Drosophila germ line
Transposable element activity represents a critical threat to host organisms due to its potential to damage the genome and disrupt gene expression. Transposons are known to be particularly active in the developmental context of the germ line, to fulfil their selfish drive to increase in copy number …
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Transposable Elements and the Evolution of Virus Resistance in Drosophila melanogaster
… genes. In this thesis I will explore the role of transposable elements in the evolution of virus resistance. We discover a Doc retrotransposon insertion in the Drosophila gene Veneno (Ven; CG9684), a gain of function mutation which confers resistance to Drosophila A Virus (DAV). We show that the …
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Transposable elements: What have you done for me lately? A genomics based investigation into the potential functional roles of transposable elements using the model organism Caenorhabditis elegans
… evidence of potential novel intron creation by transposable elements in both C.elegans and C.briggsae. These results establish evidence for the genome's adaptation to the presence of these elements, and point to the possibility of the host genome utilizing their unique characteristics to …
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Transposable prophage Mu exists as an independent chromosomal domain in E. coli
… and DNA-binding proteins. We find that transposable prophage Mu, transcriptionally silent by definition, is organized into an independent domain as determined by the close proximity of Mu termini L and R separated by a 37 kb Mu genome. Cre-loxP recombination is used in this study in vivo …
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The impact of Terminal Inverted Repeat (TIR) transposable elements on plant genomes
<p>As major components in eukaryotic genomes, Transposable Elements (TEs) have been studied for decades. In the 1950s to 1990s, the predominant opinions considered TEs as “junk DNA” and “selfish elements”. However, subsequent studies showed that TEs are important players in genome dynamics. TEs are …
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DD34E DNA Transposable Elements of Mosquitoes: Whole-Genome Survey, Evolution, and Transposition
Transposable elements (TEs) are mobile genetic elements capable of replicating and spreading within, and in some cases, between genomes. I describe a whole-genome analysis of DD34E TEs, which belong to the IS630-Tc1-mariner superfamily of DNA transposable elements, in the African malaria mosquito, …
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New insights into Transposable Elements from high quality genome sequences across diverse animals
… have opened the possibility of identifying new transposable element (TE) families by their polymorphic character in different haplotypes, in contrast to previous methods based on repetitiveness, homology and structural features. In this work, divided in four sections, I show how we can leverage …
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Mechanisms of piRNA biogenesis and co-transcriptional silencing of transposable elements in Drosophila
A large fraction of eukaryotic genomes consists of mobile, repetitive elements called transposons. Since their uncontrolled mobilisation is a potentially harmful event, several molecular mechanisms have evolved to counteract transposon activation and thus safeguard genome integrity. Among these is …
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Role of small RNAs and chromatin in transposable element silencing during global demethylation
… cell differentiation as well as silencing of transposable elements (TEs). DNA methylation is dynamic during early mammalian development, despite being a more static mark in somatic cells. Global hypomethylation is a hallmark of epigenetic reprogramming in mammalian primordial germ cells …
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Using signal processing, evolutionary computation, and machine learning to identify transposable elements in genomes
About half of the human genome consists of transposable elements (TE's), sequences that have many copies of themselves distributed throughout the genome. All genomes, from bacterial to human, contain TE's. TE's affect genome function by either creating proteins directly or affecting genome …
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HUMAN GENOME VARIATIONS AND EVOLUTION WITH A FOCUS ON THE ANALYSIS OF TRANSPOSABLE ELEMENTS
… an attempt to construct a relation between transposable elements (TEs) and tandem repeats (TRs) was made at a genome-wide scale for the first time. Upon sequence comparison, positional cross-checking and other relevant analyses, it was observed that over 20% of all TRs are derived from TEs. …
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Revealing the transposable element dynamics driving evolutionary transitions through direct observation in live cells
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-12-01
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Investigation of the Conservation of Biological Function in Transposable Elements using a Multiple Alignment Strategy
… non-coding genome was found to be occupied by transposable elements (TEs), DNA with transposition capability which can either benefit or disrupt gene functions depending on their destination. TEs are considered foreign and viral-like intruders which can affect genome integrity and therefore …
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