Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Transport receptors"”.
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Investigation of Nuclear Pore Complex Protein Interactions and the Implications for Nuclear Transport
… pore complex is responsible for controlling the transport of large molecules into and out of the cell nucleus. It is perhaps the largest protein structure in eukaryotic cells, and because of its size, pointed experimental study has been difficult. As a result, the mechanism by which the nuclear …
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Investigation of nuclear pore complex protein Interactions and the implications for nuclear transport
… pore complex is responsible for controlling the transport of large molecules into and out of the cell nucleus. It is perhaps the largest protein structure in eukaryotic cells, and because of its size, pointed experimental study has been difficult. As a result, the mechanism by which the nuclear …
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Selective transport of the nuclear pore complex studied through all-atom and coarse-grained molecular dynamics simulations
… which are only allowed to pass when bound to transport receptors. Anchored on the inner surface of the NPC central pore are many intrinsically unstructured FG-nups, proteins that contain phenylalanine-glycine repeating sequences (FG-repeats) separated by hydrophilic linker regions. Because of …
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Studies on the interaction of HSV-1 multifunctional protein ICP27 with the nuclear pore complex proteins
… TAP to export viral mRNAs. However other transport mechanisms may also be employed. All transport across the nuclear envelope must occur via the nuclear pore complex, which consists of proteins called nucleoporins (NUPs). NUPs act to regulate the transport cargos by interaction with mRNA …
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Molecular Size and Charge Effects on Nucleocytoplasmic Transport Studied By Single-Molecule Microscopy
… machinery for bidirectional nucleocytoplasmic transport. The selective barrier, which is formed by the natively unfolded phenylalanine-glycine (FG)-nucleoporins (Nups), in the NPC allows for two transport modes: passive diffusion of small signal-independent molecules (< 20-40 kDa) and …
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Discrete 3D Model of Molecular Diffusion Through the Nuclear Pore Complex
… located in the channel and a concentration of transport receptors located on either ends of the NPC. The model simulated the movement of spherical molecules through the NPC and kept track of their location during their transport. The model showed that the cargo’s movement has a distinct …