Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"Transplantable Mouse Model"”.
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In Vivo Genetic Screening to Identify Mechanisms of Resistance to Cancer Immunotherapy
… approach using CRISPR/Cas9 genome editing in mouse transplantable tumors treated with vaccination and PD-1 checkpoint blockade. We optimized the expression of CRISPR genome-editing components in immunocompetent mice and screened 2,400 genes expressed by melanoma cells for those that synergize …
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Delineating the role of prolactin-inducible protein (Pip) in breast cancer lung metastasis
… this role, our laboratory developed a novel transplantable mouse model of BC utilizing the 4T1-mouse metastatic BC cell line and determined that while over-expression of mouse homologous (Pip) suppressed tumor development in the primary tumor in the breast, it enhanced metastasis in lungs. We …