Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"Transmitted/founder"”.
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Development And Validation Of Novel Transmitted/founder Shivs For Hiv-1 Persistence And Cure Research
… various HIV-1 Envs of interest, including transmitted/founder (TF) Envs. TF SHIVs encode a substitution at Env residue 375 that confers consistent early viral kinetics in RM, although longitudinal kinetics are more variable. Further, TF SHIVs have not been evaluated for their suitability …
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Characterisation of α4β7and DC-SIGN reactivity of HIV-1 subtype C transmitted founder variants compared with chronic infection controls
Includes bibliographical references.
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The transmitted HIV-1 subtype C: characterization of the transmitted/founder full-length virus genome and the influence of early immune selective pressure on virus replication
… vaccine interventions. The early evolution of transmitted/founder subtype C virus sequences was investigated to determine the location and frequency of immune selection, and the impact of early immune escape mutations on viral replicative capacity. Single-genome amplified env sequences from 26 …
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HIV-1 strain-specific neutralizing antibody responses and the dynamics of viral evolution
… breadth is influenced by the co-evolution of the transmitted/founder (t/f) virus and earlier strain-specific neutralizing antibody (ssnAb) responses. Here we characterized the viral evolution, ssnAb and bnAbs responses in CAP292, an HIV-1 infected woman who developed bnAb responses from one year …
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The Development and Assessment of Immune Responses in Plasmid DNA, VSV-Vectored, and Virus-Like Particle HIV Vaccinations in Murine Models
… particle (VLP), and DNA; 2) immunogens: transmitted founder strain A74 N425 wild type and N425K mutant; and 3) conformational changes: vaccines with or without CD4 mimetic interaction, to identify the best vaccine candidate. We also investigated the mechanisms by which these vaccines …
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Neutralising antibody responses in acute hepatitis C and SARS-CoV-2 infection
… one at the initiation of infection (selection of transmitted/founder (T/F) variants), and another within 100 days of infection (emergence of fit variants against host immunity). Three out of four patients with HCV develop chronic infection which is associated with a delayed nAb response against …
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Evolution of adaptive immune response from acute to chronic phase of hepatitis C virus infection
… HCV-specific CD8+ T cell responses against the transmitted founder virus identified via ELISpot. Immune escape was observed in the NGS data set in ~33% of all ELISpot identified epitopes. The majority of HCV-specific CD8+ responses identified via IFN- ELSPOT in chronic progressors were also …
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Investigating the susceptibility of foreskin myeloid cells to ex vivo HIV infection
… model of suspension cells (n=17), Subtype C transmitted founder (T/F) and chronic infection derived (CC) infectious molecular clones (IMCs) were used alongside Subtype B NL4-3 IMCs with CCR5, CXCR4 and BaL envelopes. The extent of HIV infection was quantified by measurement of p24 in …
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Genome scale identification of HIV Dependency factors across multiple HIV-1 strains
In this thesis, I developed a method called HIV-CRISPR screening at genome-wide scale, and then at a smaller, targeted scale, to uncover novel genes that may act as HIV-1 dependency factors. By using a screening technique which assesses enrichment or depletion of guide based on HIV-1 release from …
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Male genital tract versus blood HIV-1 compartmentalization and selection: the first step of the transmission bottleneck?
… working on understanding the nature of the transmitted virus have reported discordant traits of transmitted/founder viruses compared to viral isolates from chronically infected individuals. Such studies therefore lacked analysis of the intermediate step between these two populations: HIV-1 …