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Showing 1 to 20 of 22 for “"Transmissible Spongiform Encephalopathies"”.
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Influence of Prion Protein Expression on Function of Excitatory Amino Acid Transporters in Mouse Primary Astrocytes
… plays an important role in the pathogenesis of transmissible spongiform encephalopathies. However, its normal function remains unclear. Mice that do not express PrP exhibit deficits in spatial memory and abnormalities in excitatory neurotransmission suggestive that PrP may function in the …
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Influence of Prion Protein Expression on Function of Excitatory Amino Acid Transporters in Mouse Primary Astrocytes
… plays an important role in the pathogenesis of transmissible spongiform encephalopathies. However, its normal function remains unclear. Mice that do not express PrP exhibit deficits in spatial memory and abnormalities in excitatory neurotransmission suggestive that PrP may function in the …
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Exploring Novel Immunodiagnostics for Prion Disease
Prion Diseases, or Transmissible Spongiform Encephalopathies (TSEs), are rapidly progressive and fatal neurodegenerative diseases of mammals. TSEs of global importance include Creutzfeldt-Jakob Disease (CJD) in humans, Chronic Wasting Disease (CWD) in cervids, and Bovine Spongiform Encephalopathy …
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Prion biology in the context of bacteria
… diseases collectively known as the transmissible spongiform encephalopathies. Prions have also been uncovered in yeast, where they function as protein-based units of heredity that confer unique phenotypic traits on those cells that harbor them. To date, the discovery of prions and …
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Effects of glycosylation on the structure and fibrillization of prion protein fragments
… from PrPc to PrPSc is the major event leading to transmissible spongiform encephalopathies. Although the mechanism of this transition remains elusive, glycosylation has been proposed to impede the PrPc to PrPSc conversion. Structural studies on glycoprotein fragments in the Imperiali group has …
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Prion protein in health and disease
… PrPSC in the pathogenesis of prion diseases, or transmissible spongiform encephalopathies, has been studied intensively yet the mechanism by which PrP misfolding in neurons leads to injury and death remains enigmatic. Much less attention has been focused on the role of PrP in normal physiology …
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Metabolic Profiling of Prions In The Gastro-Intestinal Tract
… <p>Prion diseases, also known as transmissible spongiform encephalopathies (TSEs), are a group of debilitating neurodegenerative disorders that affect both humans and animals. They can be spread by horizontal transmission as seen in chronic wasting disease in deer and elk …
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Proteins as markers of TSE infection in sheep blood
Transmissible spongiform encephalopathies (TSEs) are a group of fatal infectious neurodegenerative diseases affecting both humans and agricultural animals. TSE transmission via blood transfusion has been demonstrated experimentally in rodent, primate and sheep models. Additionally, in humans, four …
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ACUTE CELLULAR UPTAKE OF ABNORMAL PRION PROTEIN IS CELL TYPE AND SCRAPIE STRAIN INDEPENDENT
<p>Transmissible spongiform encephalopathies (TSEs) are fatal neurodegenerative diseases that include Creutzfeldt-Jakob disease, bovine spongiform encephalopathy and sheep scrapie. TSE disease pathology and mechanisms within the central nervous system (CNS) of an infected host largely remains …
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Development and Application of a Novel Assay for Rapid Identification of Cellular Prion Protein Modulators
Prion diseases, or transmissible spongiform encephalopathies (TSEs), are fatal neurodegenerative disorders caused by the misfolding and accumulation of proteins known as prions. Despite decades of research, no effective treatment is available, and the main therapeutic strategy being pursued is to …
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ACUTE CELLULAR UPTAKE OF ABNORMAL PRION PROTEIN IS CELL TYPE AND SCRAPIE STRAIN INDEPENDENT
<p>Transmissible spongiform encephalopathies (TSEs) are fatal neurodegenerative diseases that include Creutzfeldt-Jakob disease, bovine spongiform encephalopathy and sheep scrapie. TSE disease pathology and mechanisms within the central nervous system (CNS) of an infected host largely remains …
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Mielių baltymo Sup35 GNNQQNY sekos mutantinių variantų kūrimas ir jų sintezė Saccharomyces cerevisiae ląstelėse /
… and spread as an infection. Prions cause transmissible spongiform encephalopathies (TSEs), a fatal neurodegenerative disease in mammals. Neurodegenerative diseases also include amyloidoses, better known as Alzheimer's, Parkinson's or tauopathy. The sequence of the yeast protein Sup35 …
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Functional significance of Hsp70 post-translational modification in prion propagation and cellular function
… neurodegenerative diseases collectively termed transmissible spongiform encephalopathies (TSE). A breakthrough in prion research came with the studies which revealed that yeast species Saccharomyces cerevisiae contains proteins that have the ability to form prions. Sup35 is a S. cerevisiae …
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Zum Vorkommen Transmissibler Spongiformer Enzephalopathien und bakterieller ZNS-Infektionen beim Reh-, Rot- und Gamswild in Bayern
About the occurrence of Transmissible Spongiform Encephalopathies and bacterial CNS infections in roe deer, red deer and chamois in Bavaria Brain samples of 849 wild ruminants (654 roe deer, 189 red deer and 6 chamois) from Bavaria were examined for the occurrence of TSE and encephalopathies caused …
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Aggregation & Localization of a Disease-Associated Prion Protein (PrP) Mutant
… of infectious and inherited forms of transmissible spongiform encephalopathies: TSEs). A nine-octapeptide insertional mutation in the prion protein: PrP) causes a fatal neurodegenerative disorder in both humans and transgenic mice. To determine the precise cellular localization of this …
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Evaluating suspected CWD feral pig brain samples using RT-QuIC and protocol for the purification and quality control of recombinant monomeric proteins for RT-QuIC assay
… <p>Two examples of such proteinopathies are transmissible spongiform encephalopathies</p> <p>(TSE) and Parkinson’s disease (PD). TSEs are a subset of prion misfolding diseases,</p> <p>specifically identified as being transmissible to other individuals in a manner resembling</p> <p>viral, …
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Magnetic Resonance Imaging in the Assessment of Anti Prion Mediated Neurotoxicity In Vivo
… prion protein (PrPc) plays a dual role in transmissible spongiform encephalopathies (TSE), which is a group of lethal disease affecting humans and a variety of animal species. First PrPC is hypothesized to be the source of the causative agent “the prion” in TSE, as the pathologic missfolded …
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The subcellular trafficking of the prion protein: Characterisation of the function of the PrPc N-terminus
Transmissible spongiform encephalopathies (TSEs) are degenerative diseases of the central nervous system in humans and animals, and include Creutzfeldt-Jakob disease (CJD) in humans, scrapie in sheep and bovine spongiform encephalopathy in cattle. These spongiform encephalopathies can manifest as …
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Microfluidic Approaches for Investigating Aggregated Forms of Disease-Related Proteins
… In fact, prions, known to be associated with transmissible spongiform encephalopathies, have not yet been fully characterised as parts of the prion composition seem to lose infectivity through various \textit{in vitro} purification and isolation procedures. In nature, non-homogeneous solution …
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Developmental Regulation of Prion Expression in Cattle and Mouse Embryonic Stem Cells
… widely believed to be the pathogenic agent of transmissible spongiform encephalopathies (TSEs). Thus, tissues expressing PrPC are potential sites for conversion of PrPSc during TSE pathogenesis. Although much is known about the role of PrPSc in prion diseases, the normal function of PrPC is …
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