Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 78 for “"Transmembrane proteins"”.
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Polymer Supported Lipid Bilayer Membranes for the Integration of Transmembrane Proteins
… for the successful integration of functional transmembrane proteins (TMPs). As each cushion exhibits different physico-chemical properties, the resulting behaviour of the sLBMs and TMPs could be exactly adjusted to the specific requirements of biological samples. This is exemplarily shown by …
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Hydrodynamics and Diffusion of Membrane Proteins to Engineer Chemical Reactions in Synthetic Biomembrane Platforms
… in lipid bilayers, the incorporation of transmembrane proteins into SLBs, the fluidization of those transmembrane proteins, and the spatial patterning of SLBs containing different biological materials. Some of the progress made in these areas is described here. First, improvements in SLB …
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Machine learning applications for the topology prediction of transmembrane beta-barrel proteins
… on the topology prediction of beta-barrel transmembrane proteins. Transmembrane proteins adopt various conformations that are about the functions that they provide. The two most predominant classes are alpha-helix bundles and beta-barrel transmembrane proteins. Alpha-helix proteins are …
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Characterization of the Tetraspanin protein Tspan18
Tetraspanins are a superfamily of four-transmembrane proteins. They associate laterally with one another and with other transmembrane proteins to form membrane microdomains, in which associated proteins are regulated. Tetraspanins regulate diverse processes such as cell signalling and fusion, …
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RNA Localization and Translational Regulation on the Endoplasmic Reticulum
… study, we identify that the ER integral membrane proteins function as RNA-binding proteins and play important roles in the direct mRNA anchoring to the ER. We report that one of the ER integral membrane RNA-binding protein, AEG-1 (astrocyte elevated gene-1), functions in the direct ER anchoring …
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Molecular basis of cargo sorting by endosomal trafficking machinery
Faithful sorting of transmembrane proteins to their intended steady state localization is crucial for function of cellular organelles and homeostasis of an organism. Yet the vast majority of transmembrane proteins are synthesised in the endoplasmic reticulum (ER) despite the site of their function …
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FKBP14 in Notch Signalling and Drosophila Development
Presenilins (PSs) are highly conserved transmembrane proteins that form the catalytic core of the gamma-secretase complex, which cleaves a growing list of transmembrane proteins including Notch and Amyloid Precursor Protein. Autosomal dominant mutations in the genes encoding human PS have been …
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Topological Regulation of TM4SF20
Transmembrane proteins must adopt proper topology to perform their functions. It was previously demonstrated that ceramide regulates TM4SF20 (transmembrane 4 L6 family 20) by altering the topology of the transmembrane protein, but the underlying mechanism remains obscure. This regulatory mechanism, …
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Dynafold: A Dynamic Programming Approach to Protein Structure Calculation From Residual Dipolar Couplings
… involves the interactions of one or more proteins. As a result, methods for determining the three dimensional structure of proteins are of tremendous interest to researchers in a variety of fields. Presently, methods of protein structure determination are dominated by X-ray crystallography …
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Plxna4 and its role in neuronal survival in the developing zebrafish hindbrain
Plexins are a family of transmembrane proteins that bind Semaphorin ligands, and are known to function in axon guidance. In embryonic zebrafish, I find that plxna4 is expressed widely in the nervous system early in development, and localizes to the hindbrain as neurogenesis and differentiation …
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Dense Core Vesicle Heterogeneity in Anterior Pituitary Cells
… exocytosis. Two different dense core specific transmembrane proteins traffic different when comparted to retained prolactin cores, offering evidence of heterogeneity of vesicles within a single cell. By comparing synaptotagmin 1 and 7 distribution in male rat and lactating female lactotrophs, a …
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Development and application of control tools for use in optogenetics research
… such as Channelrhodopsin-2 (ChR2) are seven-transmembrane proteins that function as light-gated ion channels. These naturally occurring proteins are found in green algae and serve as sensory photoreceptors controlling phototaxis. Operationally, they contain the light-isomerizable chromophore …
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Štúdium modulácie cytostatickej rezistencie pomocou vybraných cielených protinádorových liečiv
… (ABC) transporters. These are a group of transmembrane proteins that negatively impact the efficacy of chemotherapy by reducing the intracellular concentration of drugs through their efflux out of the cells. Inhibition of these transporters appears to be a logical approach; however, no …
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Advances in structure and small molecule docking predictions for crystallized G-Protein coupled receptors
… worked on in the context of native, globular proteins. In this work it is extended to transmembrane proteins, which requires an explicit integration of the lipid bilayer into the loop prediction calculation. In the initial work, this new approach to loop prediction yields highly accurate …
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Identification of a novel metastasis enhancer, CDCP1, and analysis of its functions during melanoma metastasis
… initiation and progression, and plasma membrane proteins are the mediators for tumor-stromal communications. In this thesis, I focused on plasma membrane proteins that may contribute to tumor metastasis. I applied quantitative mass spectrometry technology to first identify plasma proteins that …
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ADDUCINS AFFECT CORTICAL NEUROGENESIS BY REGULATING PROGENITORS¿ MORPHOLOGY AND FATE
… are only partially understood. Structural proteins have already been described as determinants of BPs’ morphology and fate; among them, the family of adducins (ADDs) is of particular interest. ADD1, ADD2 and ADD3 anchor the spectrin-actin cytoskeleton to the cell membrane through their …
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THE ROLE OF TIGHT JUNCTION PROTEIN ZO-2 IN THE NUCLEUS AND ITS LINK TO TRANSCRIPTION FACTORS OF THE SLUG/SNAIL FAMILY
… an adaptor protein that is associated with the transmembrane proteins of the tight junction (TJ). It is capable of shuttling between the TJ and the nucleus and is known to participate in gene regulation through its association with gene regulators. To identify proteins interacting with ZO-2, a …
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Identification and functional characterization of the mitochondrial adenine nucleotide carriers of Trypanosoma brucei
… Mitochondrial Carrier Family encloses a group of transmembrane proteins that transport metabolites across the mitochondrial inner membrane. The ADP/ATP carrier is the most widely studied MCF protein. It catalyzes the counter exchange of ADP for ATP in the mitochondrion of all eukaryotes. In the …
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[GAR⁺] : a novel type of prion involved in glucose signaling and environmental sensing in S. cerevisiae
Several well-characterized fungal proteins act as prions, proteins capable of multiple conformations, each with different activities, at least one of which is selfpropagating. We report a protein-based heritable element that confers resistance to glucosamine, [GAR⁺]. Genetically it resembles other …
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