Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 154 for “"Translocations"”.
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Molecular Mechanisms of C11orf95 translocations in cancer.
Highly recurrent chromosome translocations that produce oncogenic fusions are a prime example of practical therapeutic targets translating into clinical successes. We have previously described the genetic driver of supratentorial (forebrain) ependymomas as translocations of the C11orf95 gene of …
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X autosome translocations in man studied with replication banding
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Role of AID and microRNA-155 in c-myc-IgH Translocations
<p>Chromosome translocations between oncogenes and the immunoglobulin (Ig) region spanning the variable (V), diversity (D) and joining (J) genes (Ig V-JH region) are found in a number of mature B cell lymphomas in humans and mice. The breakpoints are frequently adjacent to the recombination signal …
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Translocations of Actin to Nucleus and p21WAF1 to Cytoplasm after Treatment of HDF Cells with H2O2
목적 : 세포는 오랫동안 스트레스에 노출될 경우 조기노화가 유도된다. 이를 stress-induced premature senescence라 부른다. 자외선, 약물 또는 cytokine등 세포외의 자극에 의한 스트레스나 DNA 손상에 의한 스트레스에 의해 조기노화가 유도되는데, 이 경우 세포 내 활성 산소의 증가가 동반되는 것으로 알려져 있다. 본 연구에서는 human diploid fibroblast (HDF) 1차 배양체에 산화적 스트레스의 매개체의 일종인 H2O2를 한 번 또는 반복적으로 투여하여 유도되는 세포의 조기노화 …
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X-Ray-Induced Chromosomal Translocations With Reference to Genetic Control of the Mosquito Anopheles Albimanus (Wiedemann)
Made available in DSpace on 2014-12-12T01:27:46Z (GMT). No. of bitstreams: 1 7500408.pdf: 2816990 bytes, checksum: ebbfb3a68f5b6c0faa3054666dabebb4 (MD5) Previous issue date: 1974
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Human networks of tetrapod translocations in the Western Cape, South Africa: trends and potential impacts on biodiversity
… managers are increasingly turning to species translocations to achieve conservation goals. These human induced movements of wildlife have a number of potential impacts, one being the introduction of non-native species that may establish and become invasive. Although the underlying mechanisms …
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Flour quality and dough stickiness of soft red winter wheat lines with and without 1B/1R translocations
Wheat (Triticum aestivum L.) is one of the major cereals of the world. Farmers must produce wheat with good yield and quality to meet the high demands for wheat flour. To reduce disease and increase wheat yield, cultivars have been developed by replacing the short arm of chromosome 1B of wheat with …
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Efficient modeling of DNA translocations and ionic currents using coarse-grained molecular dynamics simulation and finite-element modeling
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-11-11 without embargo terms
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Efficient modeling of DNA translocations and ionic currents using coarse-grained molecular dynamics simulation and finite-element modeling
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-11-11 without embargo terms
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Genetic and Epigenetic Interactions in in vivo and in vitro Reprogramming
… AML). HOX dysregulation is seen in AML with translocations involving HOX genes themselves: e.g. NUP98-HOXA9) and with other disease-initiating translocations: e.g. MLL translocations and inv(16)). However, HOX genes are also highly expressed in many AML samples without translocations; the …
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Location of genes for resistance to Puccinia hordei otth. in the barley varieties Sudan and Reka 1 as determined by means of translocation stocks
… The F₁ plants from crosses of Sudan with all translocations and Reka with all translocations were tested for rust reaction and found to be resistant. Examination of the mature pollen showed that the F₁’s were partially sterile. In the crosses involving the variety Sudan with translocation …
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The Role of Activation-Induced Cytidine Deaminase in Antibody Diversification and B Cell Malignancies
… however, can lead to c-myc/IgH chromosomal translocations and ultimately to B cell lymphomas and plasmocytomas in mice. Such translocations can also be detected in B cells stimulated to switch in vitro. I showed that switching B cells also upregulate Rae-1, a ligand for the NKG2D activating …
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Molecular Signatures of gastric cancer: An integrated approach to molecular cytogenetics, whole genome copy number and transcriptome profiles
Signature chromosomal translocations in gastric cancer are poorly described. By integrating spectral karyotype and high-resolution genome copy number data, 45 recurrent translocations in 17 human gastric cancer cell lines were identified. Dissecting a simple rearrangement in SNU-1 cells using …
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Evolutionary and conservation genetics of the Seychelles warbler (Acrocephalus sechellensis)
… species. I then determined the impact of four translocations on genetic diversity over two decades. I found that diversity does not differ significantly between islands but the use of smaller founder sizes in two translocations has caused population divergence. These results indicate that …
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Characterisation of the leukaemia-associated ETO homologues
… is commonly associated with balanced chromosomal translocations. Characteristically, these translocations lead to the fusion of two unrelated genes, resulting in the expression of an aberrant fusion protein. t(8;21) is one of the most common translocations found in patients with AML. It results in …
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The Extent and Nature Of Chromosomal Rearrangements in B Lymphocytes
<p>Chromosomal rearrangements, including translocations, require formation and joining of DNA double strand breaks (DSBs). These events disrupt the integrity of the genome and are frequently involved in producing leukemias, lymphomas and sarcomas. Mature B cell lymphomas are unique among tumors in …
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Structural analysis of LMO2 for the development of a small molecule inhibitor
… its activation due to specific chromosomal translocations in patients with T-cell acute lymphoblastic leukaemia (T-ALL). The specific chromosomal translocations occur with either the T-cell δ receptor gene (14q11) or T-cell β receptor gene (7q35) and result in aberrant LMO2 expression in …
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Behavioural ecology of the greater bilby (Macrotis lagotis) and conservation tool development in a semi-wild sanctuary
Conservation translocations are becoming an increasingly necessary tool to stem the decline of threatened species globally. The greater bilby (Macrotis lagotis) is a nationally threatened species in Australia. While bilby translocations are expected to contribute to the species’ persistence, the …
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