Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 104 for “"Translational research"”.
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TRANSLATIONAL RESEARCH TARGETING BILIARY TRACT CANCER
… (CCA) and gallbladder cancer (GBC). In this translational research program targeting BTC, we focus on three aspects: the development of a combination treatment against CCA, the exploration of the immune background of GBC, and the establishment of a CCA mouse model mimicking mutation profiles …
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A HYBRID APPROACH FOR TRANSLATIONAL RESEARCH
Translational research has proven to be a powerful process that bridges the gap between basic science and medical practice. The complexity of translational research is two-fold: integration of vast amount of information in disparate silos, and dissemination of discoveries to stakeholders with …
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Medulloblastomas and ependymal tumours; impact of translational research on treatment perspectives.
Contains fulltext : 50581.pdf (Publisher’s version ) (Open Access)
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Modelling fragile X syndrome in rats: new directions in translational research
Fragile X syndrome (FXS) is the leading single gene cause of intellectual disability and Autism Spectrum Disorder (ASD). It is caused by epigenetic silencing of the fragile X mental retardation gene (FMR1), causing a loss of Fragile-X Mental Retardation Protein (FMRP). Over the last 2 decades, much …
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Cross-species single-cell transcriptomics and its applications in evolutionary and translational research
… of organisms inaccessible to experimental research. In this thesis, I explore these two applications in the context of early mammalian development and vertebrate brain evolution. I first detail efforts to construct a single-cell atlas of rabbit gastrulation, which offers a new window into …
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Establishing a Translational Research Center in California's San Joaquin Valley: Principles, Partnerships, and Initial Steps
… Central Valley. UC Merced's Health Sciences Research Institute (HSRI) was established in 2012 to engage in collaborative, multidisciplinary research with a community emphasis in order to rapidly develop, test, and disseminate new ways to improve health. To address the numerous health …
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Recapitulation of Human Placental Insufficiency in a Novel Mouse Model :New Paradigm in Translational Research
Objective: To develop a mouse model of placental insufficiency (PI) that recapitulates important characteristics of the human PI. We tested the effects of selective reduction of placental blood flow by mesenteric uterine artery branch ligation (MUAL) reliably resulting in fetal growth restriction …
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Utilizing Translational Research to Identify and Develop Effective Strategies for Operationalizing and Implementing a National Board Health and Wellness Coaching (NBHWC) Certification Program within the Non-Profit, Living Your Truth Empowered (LYTE)
… study that employs a combined formative and translational research design, alongside a mixed methods approach, to identify and develop strategies for operationalizing and implementing a National Board of Health and Wellness Coaching (NBHWC) certification program within the nonprofit …
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Seeing Biomedically: the Routine Grounds of Translation in Patient Oriented Research
… when taking a patient oriented approach to translational research. The two doctors collected data directly from patients and privileged patients’ personal experience of disease. One doctor presented the patient’s authentic voice of experience at an international medical conference. The …
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Exploring metabolomics through NMR: from early life to aging
… occupies a unique yet demanding position in translational research. Its proximity to phenotype and its sensitivity to clinical and environmental perturbations make it a powerful tool for understanding biological processes in real-world settings. At the same time, this very sensitivity …
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Experimental Models of Brain Hemorrhage Using Clostridial Collagenase
… novel animal models to buildup foundations for translational research of intracerebral hemorrhage. We, for the first time, established four animal models, including cerebellum hemorrhage, pontine hemorrhage, neonatal matrix hemorrhage and maternal postpartum hemorrhage. Those models are …
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Designing a state-of-the-science, accredited, commercially-successful biorepository utilizing ISO:9001(2008) quality management system requirements to construct the framework
<p>The research community relies upon biorepositories’ ability to prepare for the scientific advancement that can precipitate the discoveries of the future. Furthermore, as the complexities, financial pressure, and quality issues biorepositories face continue to unfold, it is imperative to explore …
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Computational Techniques for Advancing Photoacoustic Microscopy
… attracted considerable attention in basic and translational research. PAM not only enables in vivo label-free vascular imaging at the microscopic level, but also facilitates the assessment of hemodynamics and oxygen metabolism. However, challenges related to image contrast, spatial resolution, …
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Evaluation of resurgence following differential reinforcement of alternative behavior with and without extinction in a human-operant model
… for individuals diagnosed with autism. However, researchers have recently begun investigating DRA without extinction, given this treatment component may be unsafe or impractical to implement in practice. Although preliminary research has indicated DRA without extinction as an effective …
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Framework Development for Remote Clinical Trials: Assembly Process Design
… half after January 2020. Tufts Clinical and Translational Research Center has partnered with the Massachusetts Institute of Technology to develop a framework for a “clinical-trial-in-a-box” for use in fully remote clinical trials, which would reduce risk of infection due to the lack of …
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Exploring Neural Activities in the Prefrontal Cortex of Fragile X Syndrome Mouse Models Using Electroencephalography
… reduced signal complexity, suggesting potential translational biomarkers of network dysfunction. However, the extent to which these signatures are conserved in preclinical models—especially in female mice—remains unclear. This thesis aimed to characterize oscillatory alterations in female Fmr1 …
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Development of translational models for intervertebral disc degeneration using a comparative approach for canine and human patients
… for human patients. The main goal for this PhD research was to develop and validate canine models for human IVDD with a focus on distinguishing molecular characteristics of key disease phenotypes. Using biomarkers associated with inflammation and degradation, IVD health and disease were …
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Design and Development of a Mobile Motion Capture Suite for Advancing Technology Adoption
… initiated within MIT’s Center for Clinical and Translational Research (CCTR) to develop a portable, accurate, user-friendly, and inclusive MoCap system to be used in healthcare applications and beyond. This thesis explores the initial stages of developing the LabX system, including extensive …
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