Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 29 for “"Translational model"”.
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Zebrafish and Conditioned Place Preference: A Translational Model of Drug Reward
… rerio) has recently gained popularity as a model organism of complex brain disorders (e.g., substance use disorder). Behavioral quantification within the conditioned place preference (CPP) paradigm serves as a measure of the rewarding qualities of a given stimulus (e.g., drug). If animals …
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CD21 and CD24 Co-expression: A Translational Model between Mouse and Human
… human B cell production and function. The mouse model has provided a foundation for understanding the mechanisms involved in human B cell development and autoimmune disease. However, differences in mouse and human B cells are not fully understood. Our work shows that the co-expression of CD21 and …
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NONHUMAN PRIMATES AS A TRANSLATIONAL MODEL OF ENDOMETRIOSIS AND ITS EFFECTS ON WOMEN'S HEALTH
… objectives were to use a nonhuman primate (NHP) model of endometriosis to address gaps in knowledge surrounding tissue macrophage function, endometriosis and eutopic endometrium metabolism, and systemic iron metabolism. The overall hypothesis for this research was that macaque NHPs provide a …
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Evaluation of the therapeutic potential of Akt inhibition in a translational model of histiocytic sarcoma
… potential of Akt-targeted therapy in a canine model of histiocytic sarcoma. We demonstrated Akt signaling to be active in 9 out of 10 canine HS tumor samples, regardless the presence of PTEN. Moreover, the Akt signaling pathway appears to be constitutively active in DH82 cells — a cell line …
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The Rat as a Translational Model of Neurotrauma: Primary Somatosensory Input and Imaging Biomarker Validation Following Spinal Cord and Peripheral Nerve Injuries
… and difficult to study, necessitating the use of translational models that provide standardizable and quantifiable models of injury. Rats are the most commonly used models of spinal cord (SCI) and peripheral nerve (PNI) injuries because their anatomy and physiology approximates that of humans, …
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CBD & Ethanol Disrupt Early Embryonic Development
… have rarely been studied. Zebrafish, a viable translational model for embryonic and neural development, is a cost-effective and translational model that has previously been used in drug research. In the present study, zebrafish embryos were chronically exposed to CBD for 10 days. Embryonic …
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Face recognition under varying illumination, pose and contiguous occlusion
… Patch Matching, which combines a local translational model for deformation due to pose with a linear subspace model for lighting variations. This algorithm gives surprisingly competitive performance for moderate variations in both pose and illumination, a domain that encompasses most …
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Assessment of early-life choline and iron deficiencies on neurodevelopment in the young pig
… worldwide. The pig has emerged as an important translational model for studying neurodevelopmental outcomes influenced by pediatric nutrition. The use of magnetic resonance imaging allows for a non-invasive understanding of how nutrition affects neurodevelopmental patterns and is amendable to …
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Characterizing canine dose from external beam irradiation
… Since dogs have been shown to be a valuable translational model for human radiation effects, accurate estimation of canine CT dose may permit future deterministic and stochastic radiobiological effect studies to be performed with canines on a much shorter time scale than similar studies with …
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Modeling and Mapping Addiction in the Zebrafish, Danio rerio
… addiction behaviors expressed have not yet been modeled and correlated in zebrafish, a viable translational model for studying drug addiction. In the present study, addictive behaviors in zebrafish were elicited after fish were exposed to amphetamines through a condition place preference …
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Efficacy of using robotics to characterize impaired upper-limb function in a non-human primate model of stroke
… resemble humans and may represent an animal model that could help bridge the translational gap preceding clinical trials. Additionally, robotic technology has been proven to provide objective determination of outcomes in human stroke populations and it is possible that these outcomes are …
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Nanoparticle preconditioning for enhanced thermal therapies in cancer.
… perfusion. In this work, we used an in vivo model system of cryosurgery of human prostate cancer (LNCaP Pro 5) grown in nude male mice. We show that 4 hour pre-treatment with our nanoparticle system leads to a dramatic reduction in tumor blood perfusion with a simultaneous increase in tumor …
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The Role of Hyaluronan in the Ocular Surface
… atrophy assessed. (4) In order to provide a more translational model of ARMGD to humans, non-human primate (NHP) eyelids at varying ages were assessed and compared to human eyelids. Results: (1) Limbal stem cells cultured onto HA retained their stem cell characteristics such as putative stem cell …
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Perinatal hypoxic-ischemic brain injury – characterization, mechanisms and treatment
… I showed for the first time in a perinatal model that profound release of adenosine triphosphate occurs during the latent phase, highlighting abnormal purinergic signaling as a future direction of research. My research also suggested that targeting neuroinflammation and persistent white …
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A Translational Study Evaluating the Uses of Diagnostic and Therapeutic Practices Established in Human Malignant Melanoma in Equine Malignant Melanoma
… species, with the horse representing a useful model for this process. One novel therapy, frankincense oil (FO) is a resin distillate from trees of the genus Boswellia. Studies have demonstrated cytostatic and apoptotic-modulating properties of FO in various human cancer cell lines. No studies …
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Modeling Neural Stem Cell Dynamics in Congenital Heart Disease
… and an expansive outer SVZ, provides a powerful translational model system for the study of how heart dysfunction impacts cortical development from both a modern and evolutionary perspective. The present study provides a detailed characterization of neuroblast migration along their associate …
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Investigations into the role of inflammation in tumorigenesis
… the use of canine HS both as an experimental and translational model, we sought to create a murine xenograft model. In Chapter 5, we discuss the development of our model and the results of pilot studies using targeted drug therapy. The focus of Chapters 3-5 is to further explore the role of …
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Overcoming therapeutic resistance in glioblastoma using novel electroporation-based therapies
… of spontaneous canine gliomas as an ideal translational model for investigations into novel treatment approaches. Chapter 2 introduces novel ablation methods (i.e. IRE/H-FIRE) capable of targeting treatment-resistant cancer stem cells. The focus of Chapter 3 is to highlight IRE applications …
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Targeting Mitochondrial ROS Production in Kidney Transplantation
… ROS production and ameliorate IRI in models of kidney transplantation. Herein, I show that the metabolic changes required for mitochondrial ROS production on reperfusion, including succinate accumulation and the depletion of adenine nucleotides, occur in grafts retrieved from both DBD …
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Drosophila melanogaster Genetic Model of Parkinson’s Disease: phytotherapy approach for a new and more sustainable pre-clinical investigation
… melanogaster (Dm) is a valuable genetic model for exploring molecular, genetic and cellular aspects of neurodegeneration in Parkinson's disease (PD), for further understanding its etiology and pathogenesis and making valid contributions to drug screening. This study used two …
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