Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 44 for “"Translational Medicine"”.
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Innovations in biomedical optical imaging for translational medicine: from in-vitro organoid analysis to vascular mapping in dermatology
L'abstract è presente nell'allegato / the abstract is in the attachment
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XMARCUS: A Pathway Towards Remote Robotic Surgery Coaching
… discuss application towards future directions of translational medicine, adoption of surgical tools, and innovation within medicine. XMARCUS indicates the possibility of another artificial intelligence winter within surgery domain and presents a direction towards surgical training. Our macroscopic …
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Enhancing the Data, Information and Knowledge from Proteomics Experiments through Biomedical Informatics
… is a fast growing area of research to promote translational medicine and is discussed as an alternative to reductionism. In this work, shotgun proteomics is utilized along with systems thinking to quantify numerous proteins simultaneously and presents an unbiased, collective view of human …
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Axl RTK and microRNAs in urogenital cancers
This thesis is based on four projects focused on the Axl receptor tyrosine kinase (RTK) and microRNAs in clear cell renal cell carcinoma (ccRCC) and in prostate cancer (PCa). Paper I focuses on differentially expressed microRNAs in ccRCC. We used bioinformatics methods to identify candidate …
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The Molecular Mechanism of Platelet Activation in Inflammation
… The integration of molecular insights with translational medicine underscores the importance of targeted, multi-faceted strategies in mitigating histone-induced thrombosis and improving patient outcomes.
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The values and ethics of biomedical engineering practices in the design of novel biotechnologies
… within the broader institutional context of translational medicine. The NIH conceptualizes translational biomedical research along a five-stage progressive roadmap of scientific activities, and in this project, depicts the starting research location of both cellular and biomedical device …
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Improved quantification in small animal PET/MR
In translational medicine, complementary functional and morphological imaging techniques are used extensively to observe physiological processes in vivo and to assess structural changes as a result of disease progression. The combination of magnetic resonance imaging (MRI) and positron emission …
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Role of Polyphenolic Compounds in Chemoprevention of Breast Cancer Stem Cells
… These findings provide novel evidence in translational medicine, highlighting the effectiveness of a natural epigenetic modulator in chemoprevention by specifically targeting CSCs.
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Dual regulation of transcription factor Nrf2 by Keap1 and the beta-TrCP/GSK-3 in cancer
… controlling Nrf2 activity is important in translational medicine.<br/><br/>Nrf2 is regulated by proteasomal degradation by Kelch-like ECH-associated protein 1 (Keap1) an E3 ubiquitin ligase substrate adaptor protein that recruits of cullin-3 (Cul3) to Nrf2 via its Neh2 domain. Nrf2 is also …
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Targeting Inflammation in Atherosclerosis: The Role of Low-dose Interleukin 2 in Acute Coronary Syndromes
… together concepts of contemporary elements of translational medicine such as drug re-purposing, personalised medicine, and use of surrogate clinical endpoints through the application of imaging biomarkers. This work presents promising data for the safety and anti-inflammatory effect of low-dose …
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Sex as a Biological Variable in Preclinical Animal Studies with an Infectious Disease Exemplar.
… To extend this framework into a second, more translationally relevant model, the influence of sex hormones on the vaginal ecosystem was characterized in rhesus macaques across the menstrual cycle. Immune profiling revealed stable peripheral populations (CD45, CD4, CD8, CD56, CD123), with a …
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Developing novel prophylactic approaches against SARS-CoV-2 infection
Prevention of SARS-CoV-2 entry into cells through the modulation of viral host receptors, such as ACE2, could represent a new chemoprophylactic and therapeutic approach for COVID- 19 complementing vaccination. However, the mechanisms controlling ACE2 expression remain elusive, partly due to low …
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Dissecting the genetic bases of severe malaria resistance using genome-wide and post genomewide study approaches
… studies that can potentially lead to translational medicine including development of new vaccines and therapeutics. However, ‘-omics' studies including those implemented in this study, are limited to single datatype analysis and lack adequate power to explain the complexity of …
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Lung Defects Contribute to Respiratory Symptoms in a Mecp2-mutant Mouse Model of Rett Syndrome
Rett syndrome (RTT) is a progressive neuro-metabolic disorder caused by mutations in the X-linked gene, methyl-CpG-binding protein 2 (MECP2). After a period of seemingly normal post-natal development, RTT patients experience a developmental regression, consisting of loss of acquired verbal and …
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Making Stem Cell Niches: An Ethnography of Regenerative Medicine in Scotland and the United States
… stem cell cultures within national projects of translational regenerative medicine. This analysis both draws upon and contributes to the social studies of biomedicine, reproductive studies and science and technology studies. I examine how stem cell scientists, involved in an international …
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BASIC SCIENCE FOR TISSUE ENGINEERING IN VETERINARY ORTHOPAEDIC RESEARCH
La complessa micro- e macro- struttura del menisco richiede un approccio multidisciplinare per aumentare le conoscenze ad oggi disponibili circa la biologia che ne caratterizza lo sviluppo. Nel tessuto degli animali adulti è possibile distingue tre zone a seconda della vascolarizzazione, della …
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Degradational and Transcriptional Investigations of the RAF Kinase Inhibitory Protein
RKIP (Raf-1 kinase inhibitory protein) is a novel potent metastasis suppressor by its function of inhibiting ERK pathway, NF-κB pathway, and GRK-2. RKIP expression level is reported to be critical in the differentiation process and the pathogenesis of many different cancers and inflammatory …
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Pathology and mechanisms of increased M.tb growth and dissemination during co-infection with HIV-1
… work provides an important framework for future translational studies into co-infection pathology and mechanisms.
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EVALUATION OF THE HEPATIC MICROENVIRONMENT BEFORE AND AFTER ANTIVIRAL THERAPY FOR CHRONIC HEPATITIS C
Hepatitis C virus (HCV) infection remains a substantial global health burden, affecting millions annually despite recent therapeutic advances. Direct-acting antiviral (DAA) therapies have transformed clinical management, achieving cure rates exceeding 90% and significantly reducing complications …
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