Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 82 for “"Translational Medical Research"”.
-
Safety of Slow Release Lipopolysaccharide (LPS) Pellet in a Swine Model and Development of an Exogenous Reference Control for Real Time PCR
… provide some clues to the development of CIAO. Translational medical research relies upon animal models for studying complex human conditions, such as CIAO. Simpler rodent models assist in unraveling certain biological connections, but their predictive value for devising appropriate and …
-
Social-Demographics, Health Behaviors, Telomere Length In Mexican-American Cohort and Circulating Dna Methylation In Bladder Cancer
<p><strong>I.</strong><strong> SOCIAL-DEMOGRAPHICS, HEALTH BEHAVIORS, AND TELOMERE LENGTH IN MEXICAN AMERICANS: A COHORT STUDY</strong></p> <p>Recent studies using a prospective cohort design have suggested that telomere length in peripheral blood leukocytes is not only a potential indicator of …
-
Clinical Significance of Homologous Recombination Deficiency Score Testing In Endometrial Cancer
<p><strong>Objectives: </strong>Homologous recombination deficiency (HRD) score is related to chemotherapy response in breast and ovarian cancers. The role of HRD is unknown in endometrial cancer. We examined the relationship between HRD score and survival in a cohort of endometrial cancer patients …
-
TRANSLATIONAL RESEARCH TARGETING BILIARY TRACT CANCER
… (CCA) and gallbladder cancer (GBC). In this translational research program targeting BTC, we focus on three aspects: the development of a combination treatment against CCA, the exploration of the immune background of GBC, and the establishment of a CCA mouse model mimicking mutation profiles …
-
SIK2 Inhibitor GRN-300 Enhances Sensitivity to Paclitaxel Treatment in Triple-Negative Breast Cancer
<p>Breast cancer is one of the most frequently diagnosed cancers worldwide, with approximately 15% classified as Triple-Negative Breast Cancer (TNBC). TNBC lacks expression of estrogen (ER) and progesterone (PR), and does not overexpress HER-2, leaving patients without effective targeted therapies. …
-
A Novel NGS Assay to Detect Any KMT2A Fusion Transcript at Low Levels
<p>Measurable residual disease (MRD) detection is associated with cancer relapse. Leukemias with rearrangement of the lysine methyltransferase 2 A gene (<em>KMT2Ar</em>) have an adverse prognosis with more than 80 possible fusion partner genes (FPG) identified. With the advent of effective targeted …
-
Her4 Promotes A Stem-Like Phenotype In Osteosarcoma
<p>Metastatic disease to the lungs is the primary cause of death for patients with pediatric osteosarcoma (OS). OS has a high degree of heterogeneity and genomic instability, making understanding the pathogenesis and drivers of metastasis of this disease challenging. In an effort to explain tumoral …
-
Discovery and Development of Predictive Biomarkers for the Personalization of Pemetrexed Therapy in Non-Small Cell Lung Cancer
… the leading cause of cancer-related deaths. This research proposal was designed to personalize and improve overall response rates to the FDA-approved chemotherapeutic pemetrexed. To do so, clinically-applicable response phenotypes of a large panel of lung cancer lines needed to be defined to …
-
Relevance of Fgfr1 and Its Isoforms In Prostate Cancer Bone Metastases
<p>The fibroblast growth factor receptor (FGFR) 1 is implicated in prostate cancer (PCa) progression. Various FGFR1 isoforms have been described and we demonstrate here that the well-characterized FGFR1 a and b isoforms are correlated with the expression of different genes and pathways in human …
-
Developing Novel Therapies Targeting the Tumor Microenvironment of Aggressive Breast Cancer
<p>Triple-negative breast cancer (TNBC) and inflammatory breast cancer (IBC) are the most aggressive breast cancer subtypes. The tumor microenvironment (TME) is critical in driving these aggressive breast cancers' clinical phenotype and aggressiveness. Therefore, we explored novel actionable …
-
Isolation of Therapeutic Antibodies Against Microseminoprotien to Potentially Overcome Resistance to Anti-Angiogenic Therapy
<p>High-grade serous ovarian carcinoma (HGSC) is an aggressive subtype of epithelial ovarian carcinoma (EOC) and remains the most lethal gynecologic cancer. Angiogenesis is a vital function for both wound healing and oxygen homeostasis and is one of the hallmarks of cancer in solid tumors. To …
-
Redirecting T Cells With Chimeric Antigen Receptors to Target Cd123+ Leukemia
<h1>ABSTRAC</h1> <h1><strong> R</strong><strong>E</strong><strong>D</strong><strong>I</strong><strong>R</strong><strong>E</strong><strong>C</strong><strong>T</strong><strong>I</strong><strong>N</strong><strong>G T CELLS WITH CHIMERIC ANTIGEN RECEPTORS TO TARGET CD123</strong><strong>+ …
-
Exosome- and Microrna-based Therapeutic Approach for Tendinopathy
… use, and development of new treatments face many translational hurdles.</p> <p>Previous studies in our lab reported that Ex3D, exosomes secreted by tendon stem/progenitor cells (TSPCs) grown on a specialized scaffold, showed efficacy in tendinopathy. However, TSPCs are not feasible for clinical …
-
Translational Modeling of Non-Invasive Electrical Stimulation
… models are being applied to these areas of research, especially in the design and analysis of clinical montages. However, additional research on the parameterization of models remains.</p> <p>In this dissertation, Finite Element Method (FEM) models of current flow were developed for clinical …
-
A Novel Syndecan-1 Targeted Therapeutic Antibody Inhibits Macropinocytosis and Induces Anti-Tumor Immunity in Pancreatic Cancer
<p>Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest malignancies, with an overall 5-year survival rate of only 13%. Given the prevalence of oncogenic <em>KRAS</em> mutations (<em>KRAS*</em>) and their role in PDAC development and growth, therapeutic strategies to quench …
-
Genomic Evolution of Chemoresistance In Triple-Negative Breast Cancer Delineated By Single Cell Sequencing
<p>Triple-negative breast cancer (TNBC) is an aggressive subtype that displays extensive intratumor heterogeneity and frequently (46%) develops resistance to neoadjuvant chemotherapy (NAC). Currently, the genomic basis of chemoresistance remains poorly understood. An important question is whether …
-
Targeting The Redox System to Overcome Mechanisms of Drug Resistance In Chronic Lymphocytic Leukemia
<p>Chronic Lymphocytic Leukemia (CLL) is the most common form of leukemia diagnosed in Western countries and is characterized by clonal expansion of B cells. The clinical course of CLL is diverse and nearly 50% of patients present with chromosomal abnormalities. Deletion of the short arm on …
-
Receptor Tyrosine Kinases-Mediated Acquired Parp Inhibitor Resistance In Breast Cancer
<p>Leveraging compromised DNA damage repair (DDR) pathways commonly found in tumor cells, a classic strategy in cancer therapy is inducing excessive DNA damage to cause cancer cell death. Small molecule poly(ADP-ribose) polymerase (PARP) inhibitors (PARP-is) have been approved for clinical use in …
-
Trichuris Muris Whey Acidic Protein Induces Type 2 Protective Immunity Against Whipworm
<p>Human whipworm (<em>Trichuris trichiura</em>) infects approximately 1 in 15 people worldwide, representing the leading infectious cause of colitis and subsequent, inflammatory bowel disease (IBD). Current control measures focused on mass deworming have had limited success due to low drug …
-
Molecular Determinants of Residual Disease In Ovarian Cancer
<p>The standard treatment for high grade serous ovarian cancer is primary cytoreductive surgery followed by adjuvant chemotherapy. Residual disease followed by surgery is associated with adverse overall and progression-free survival as well as poor response to adjuvant chemotherapy. Accurate …
Page 1 of 5