Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 71 for “"Translational Control"”.
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Mechanisms of Translational Control
… to investigate the fundamental mechanisms of translational control in ribosomes. Specifically, we examine the molecular basis of Sec stop codon suppression and insertion, as well as the phenotypic consequences of perturbations to this process. Additionally, we explore how ribosome-binding …
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RNA regulatory elements and translational control
… response to environmental stimuli, and control of virulence to establish an infection. In this work, the translational landscape of *Salmonella* Typhimurium and *Listeria monocytogenes* was analysed using a ribosome profiling method adapted for examination of bacteria which yielded …
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Translational control mechanisms in the p53 response network
… networks p53 regulates. To investigate mRNA translational control as an additional dimension of p53-directed gene expression responses, we performed translatome analyses upon its activation either by different agents or cellular contexts. Considered as a proxy for the proteome, the …
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The Role of Queuine Deficient tRNA in Translational Control
… of tRNA modification with respect to queuine on translational efficiency. Transfer RNA from neoplastic cells is generally deficient with regard to certain hypermodified nucleosides found in normal cells. The hypothesis that was examined is whether or not the altered efficiency of translation can …
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Post-translational control of <em>Bacillus subtilis</em> biofilm formation
… matrix. Entry into a biofilm is exquisitely controlled at the level of transcription and in Bacillus subtilis it requires the concerted efforts of several major transcription factors including the repressor SinR and activator DegU. I initially identified that these transcriptional regulators …
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Investigating translational control of the ribosome using molecular dynamics simulations
… protein synthesis by the ribosome is tightly controlled by cofactors and a range of biological processes. In this thesis, we aim to investigate four translational control mechanisms that bring the ribosomal PTC into focus: (1) abolishment of ribosomal translation by the antibiotic action of …
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Translational Control of Protein Synthesis During Ageing in Rhizoctonia Solani
Made available in DSpace on 2015-05-14T15:08:30Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 7804125.PDF: 5684820 bytes, checksum: cde8435a7d39b5d5f78b4f28ce270d73 (MD5) Previous issue date: 1977
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Post-translational control of mitochondria by Fbxo7 in Parkinson's disease
Parkinson’s disease is a progressive, neurodegenerative disorder which is characterised by the loss of dopaminergic neurons within the substantia nigra. At a cellular level, mitochondrial dysfunction, oxidative stress and proteasomal dysfunction are all implicated in the pathogenesis of the …
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Engineered synthetic translational control for next generation mRNA gene therapies
… had not developed sufficient synthetic circuit control devices at the translational level due to 1) lack of perceived need and 2) deficiency of available natural systems for adaptation. In this thesis, I present the construction of a diverse synthetic biology toolbox for RNA-only synthetic …
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Mechanisms of selective translational control under short-term high light stress
… translated upon high light stress is controlled on multiple regulatory levels and plays an integral role for the required tailored response.<br /><br /> Several retrograde signals and signal transduction elements affect the cytosolic translational machinery. They include i.a. energy …
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Sam68, Stress Granules, and translational control of HIV-1 nef mRNA
… induction and nef mRNA sequestration account for translational suppression of Nef expression and offer a new strategy for development of anti-HIV therapeutics. Sam68 is implicated in a variety of other important cellular processes. Our findings that Sam68 variants were able to induce SG formation …
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Translational Control by the Ribosome-Associated Complex in the Unfolded Protein Response
… current hypothesis predicts that RAC supports co-translational folding of nascent cytosolic polypeptides. To directly test this hypothesis, I altered levels of RAC components and monitored the cytosolic heat shock response (HSR) and the unfolded protein response (UPR) in the ER, two stress …
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Regulation of glycogen metabolism and translational control in response to nutritional limitation
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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A Nascent Peptide Code for Translational Control of mRNA Stability in Human Cells
Stability of eukaryotic mRNAs is associated with their codon, amino acid, and GC content. Yet, coding sequence motifs that predictably alter mRNA stability in human cells remain poorly defined. Here, we develop a massively parallel assay to measure mRNA effects of thousands of synthetic and …
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The cue induced axonal nascent proteome and its translational control mechanisms in neural wiring
… full landscape of proteomic changes and their translational control mechanisms remain unknown. The ability to investigate the nascent proteome on subcellular compartments has been hampered by the low sensitivity of existing methodology on quantity-limited samples combined with the difficulty of …
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Biochemical Studies of the ER Resident Kinase PERK and Implications for Local Translational Control
… (UPR) is a highly conserved protein quality control mechanism that becomes activated in response to misfolded protein accumulation in the endoplasmic reticulum (ER) resulting in ER stress. The ER resident kinase protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) is able to couple …
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A systems-level analysis of dynamic reprogramming of RNA modifications in the translational control of cellular responses
… of 20-35 different RNA modifications in all translationally-related non-coding RNAs suggested the possibility of systems behavior of RNA modifications in translational facets of cellular responses. The studies presented in this thesis utilize a quantitative systems-level approach to test the …
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Mechanism of Translational Control by the Fragile X Mental Retardation Protein and Creation of the FMRP CTAG Mouse
<p>The Fragile X Mental Retardation Protein (FMRP) is a neuronal RNA-binding protein that is predominantly associated with polyribosomes. Loss of FMRP results in Fragile X Syndrome, characterized by mental retardation, autism and epilepsy. FMRP was recently found to be associated with a specific …
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Mechanisms of translational control by the ubiquitin E3 ligase neural precursor cell expressed developmentally down-regulated gene 4-like, Nedd4-2
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-05-01
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